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Pfizer announced Friday that it would submit a request to the FDA Friday for its COVID-19 vaccine to be granted Emergency Use Authorization.Earlier this week, Pfizer said that a final analysis of trial results showed the vaccine is 95% effective.“Our work to deliver a safe and effective vaccine has never been more urgent, as we continue to see an alarming rise in the number of cases of COVID-19 globally. Filing in the U.S. represents a critical milestone in our journey to deliver a COVID-19 vaccine to the world and we now have a more complete picture of both the efficacy and safety profile of our vaccine, giving us confidence in its potential,” Dr. Albert Bourla, Pfizer Chairman and CEO, said in a press release.Pfizer's two-shot vaccine has already been in mass production for months, and thousands of doses will be ready for delivery if and when the FDA grants authorization. Pfizer says that is on track to produce 50 million doses of the vaccine by the end of 2020 and plans to produce 1.3 billion doses of the vaccine in 2021.According to "Operation Warp Speed," the federal government's plan for distributing the vaccine, upon authorization, the drug will initially be rationed for high-risk populations and health care workers. Dr. Anthony Fauci, the nation's top infectious disease expert, says he believes a vaccine won't be widely available until April.On Wednesday, Pfizer announced that a final analysis of its vaccine candidate showed that of 40,000 participants who participated in the trial, 170 people had contracted the virus. Of those 170 people, 162 received only a placebo injection — meaning just eight out of the 20,000 people who actually received the vaccine contracted the virus.The company added Wednesday that there have been no safety concerns with the vaccine. In a randomized survey of 8,000 participants, only 2% reported suffering severe fatigue, and only 4% reported suffering severe headaches. Those who say they suffered side effects only experienced them briefly after vaccination.Pfizer's announcement comes as COVID-19 cases are spiking around the world. In the U.S. alone, about 2.5 million people have contracted the virus in the month of November alone. Hospitalizations linked to COVID-19 are at an all-time high, and deaths have begun to tick up in recent weeks. 2322

PHILADELPHIA (AP) — A night of peaceful protests in Philadelphia gave way to more unrest and some demonstrators clashed with police after a Black man was killed by officers in a shooting caught on video.Police say Walter Wallace Jr. was wielding a knife and ignored orders to drop the weapon before officers fired shots at him Monday afternoon.The lawyer for the Wallace family says they had called for an ambulance to get their son help with a mental health crisis, not for police intervention.“I find it extremely, extremely emotionally taxing to think about calling for assistance and wind up with the people who you called killing you. I can’t even conceive the concept,” said the family’s attorney, Shaka Johnson.Tuesday night, about 500 people upset by the 27-year-old’s death marched to a police station, where they were met by officers with riot shields. Police say some of the demonstrators threw debris at officers, and two were injured.There were sporadic reports of arrests in other areas and video showed people streaming into stores and stealing goods as they left on the opposite side of the city from where Wallace was shot.Following the night of unrest, a White House statement asserted that it was another consequence of what the administration called “Liberal Democrats’ war against the police.”The shooting victim’s father, Walter Wallace Sr., told CNN on Tuesday that he wants any looting or violence in his son's name to stop in the city.“It’s not going to solve anything,” he told Chris Cuomo. “It’s just going to make things worse and my son wouldn’t want that. I want it done by the legal way.” 1627

Paul Manafort's former son-in-law has reached a plea agreement with the US attorney's office in Los Angeles, which has been investigating Jeffrey Yohai's real estate deals for over a year, according to two sources familiar with the matter.Under the plea agreement Yohai will be required to cooperate with other investigators but one source told CNN it is unlikely he has much to offer to special counsel Robert Mueller.It's not clear what Yohai will be pleading to as part of the deal. He has not been publicly charged by prosecutors, though he has been under investigation.His guilty plea is all about his real estate Ponzi scheme -- he defrauded actor Dustin Hoffman, among others. Yohai will also have to cooperate with an investigation by the New York Attorney General's Office, which has an open investigation into Manafort. That probe is in the shadows of Mueller's investigation.Reuters first reported the plea deal had been reached.Yohai met with Department of Justice investigators in New York in the summer of 2017, according to two other sources familiar with the matter.Yohai provided information and documents to federal investigators in New York at the time, according to one of the sources.Yohai's lawyer did not immediately return a request for comment.The sources say the Justice Department was seeking cooperation related to the federal investigation into Manafort for possible money laundering or tax violations in his business dealings with pro-Russia political parties in Ukraine.The information was turned over to Mueller as part of his probe. It's unclear if any of the information Yohai provided has been useful for the investigation of Manafort. 1678

Our hearts are broken and our thoughts are with Chadwick Boseman’s family. Your legacy will live on forever. Rest In Peace. pic.twitter.com/DyibBLoBxz— Marvel Studios (@MarvelStudios) August 29, 2020 207

PHILADELPHIA (AP) — The driver of a stolen ambulance has been nabbed after leading police on a chase through Philadelphia that lasted more than an hour. A police spokesman says the man tried to run over an officer who shot him three times before the chase began. The officer was struck and hospitalized with non-life-threatening injuries. Police say the man stole the emergency vehicle as authorities responded to reports of a domestic disturbance requiring medical attention at a motel.His name wasn't immediately released as he has yet to be charged with a crime. He was taken to a hospital. 601