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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

The 13-year-old suspect in a crime that's shocked a close-knit college community is not all that much younger than the teenage victim.The boy was arrested in New York in connection with the death of 18-year-old Barnard College freshman Tessa Rane Majors, according to a law enforcement source familiar with the investigation.He was found with a knife and admitted being involved in the attempted robbery and stabbing, the source said Friday. The teen also mentioned two other possible suspects, and police were investigating that lead, the source said."We lost a very special, very talented and very well-loved young woman," Majors' family said Friday in a statement. "Tess shone brightly in this world and our hearts will never be the same."The killing has unsettled students and staff from the Charlottesville, Virginia, boarding school where Majors graduated this year to those at the sprawling, urban Manhattan campus that Barnard shares with Columbia University."Tess was a shining light in our community, a good friend, respected classmate, trusted teammate, and creative and passionate musician," said David Lourie, head of St. Anne's-Belfield School, where counselors were provided for students and alumni."Her death is an immeasurable loss, and we mourn alongside the Majors family and all who knew and loved Tess."Police recommend charges of second-degree murder, first-degree robbery and criminal possession of a weapon against the suspect, the source said. Prosecutors will decide the charges and whether the suspect will be prosecuted as an adult.The suspect was observed by police Thursday in the lobby of a building near the Manhattan neighborhood where the stabbing occurred one day earlier, according to the source. He was wearing clothes matching the description given for the suspect in the Barnard student's killing. He was picked up on suspicion of criminal trespass.Majors, 18, had been walking Wednesday evening through Morningside Park -- at 116th Street and Morningside Drive, just blocks from Barnard's campus -- when police believe she was confronted by between one and three assailants, New York Police Department Chief of Patrol Services Rodney Harrison said.A witness who spoke with the NYPD said Majors was confronted by four or five males in the park, according to a law enforcement official familiar with the investigation.After the attack, she stumbled up a flight of stairs to street level before collapsing at a security booth near campus, the official said. A school security officer called 911."The public safety officer assigned to the guard booth ... was at his post last night when Tessa Majors emerged from the park, and he came to her aid immediately upon recognizing that she was injured," said a statement from Columbia University.Majors' cell phone was found not far from where she fell, and she did not have a purse or wallet with her, the official said. She died at a hospital soon after, New York Mayor Bill de Blasio said.Majors is believed to have been a victim in one of two robbery patterns in the area, according to the source.A pattern of crimes and the police responsePolice officials and de Blasio faced questions Thursday about crimes in and around the park. The NYPD had identified issues and implemented strategies to combat the problem, Harrison said. The department also increased patrols in and around the park and the nearby schools, including Barnard."The idea that a college freshman at Barnard was murdered in cold blood is absolutely not only painful to me as a parent, it's terrifying to think that that could happen anywhere," de Blasio said at the news conference."It's unbelievable to me that that could happen here, next to one of our great college campuses," he added. "It's an unacceptable reality."The city has offered Barnard College any help it needs, and it's sending mental health professionals to help students deal with the news, de Blasio said."This is an unthinkable tragedy that has shaken us to our core. Please know that we are all grieving together and I am thinking of you as we process this awful news as a community," Barnard College President Sian Leah Beilock said, adding that Barnard's public safety department provides 24/7 escort service for students.'A personality no one could ever copy'Majors' family is en route to New York City, Beilock said."Tessa was just beginning her journey at Barnard and in life. We mourn this devastating murder of an extraordinary young woman and member of our community," she added.People who commented on Majors' Instagram page and spoke to CNN described her as a kind young woman and devoted musician."She was one of the sweetest people I know. She had a kind heart," Lydia Pickering told CNN. As kids, she and Majors lived two houses away from one another in Waynesboro, Virginia, Pickering said. Majors was like an older sister, she told CNN."I can't even begin to explain the impact she had on me," Pickering said. "She brought joy wherever she went. She had a personality no one could ever copy, she was really just special."Lexi Phelan, who met Majors this year at Barnard, shared two classes with her."Anyone who was lucky enough to meet her would agree that she was a good, kind person," Phelan said. "Her personality put others at ease and she lit up any room she was in with her passion."Barnard College is an all-women's school in Manhattan with more than 2,600 students. The school's campus stretches from west 116th Street to west 120th Street off Broadway in the Morningside Heights neighborhood of New York City."The close-knit community at Barnard College is in shock right now," de Blasio said in a tweet. "We've lost a young woman full of potential in a senseless act of violence. I want every student and every member of faculty to know your city will be with you in the days ahead." 5844

The Daytona Beach International Airport in Florida was briefly evacuated Tuesday morning after a suspicious package was found.The Volusia County Sheriff's Office confirmed in a tweet that the airport had been evacuated."Daytona Beach International Airport @FlyDAB is being evacuated due to a suspicious package reported around 6:15 a.m. Please check back here for updates - we'll post more info as it becomes available," the sheriff's office posted.The Daytona Beach International Airport later tweeted that the a bag was marked a suspicious as it was screened at security. The bag has since been cleared. Operations are expected to resume at the airport shortly."Attention: due to a suspicious bag that was flagged while going through security, the DAB terminal was evacuated this morning. The bag has since been cleared and normal operations will resume soon," Daytona Beach International Airport's tweet read. 925

The major television networks will provide wall-to-wall coverage of President Donald Trump's prime time address on border security on Tuesday.NBC, ABC, CBS and Fox broadcast network all said on Monday that they had agreed to the White House's request for air time.CNN, Fox News and MSNBC will all carry the address live, as well.Presidents have been using Oval Office addresses to make big announcements for decades. But this is Trump's first time using the setting for an address to the nation. On Monday the White House requested air time for the speech, as is customary in the relationship between a president and the press.But for a few hours, it was unclear what the networks would do.Trump announced his plan for the 9 p.m. ET Tuesday address via Twitter. In his tweet, he characterized the situation on the border as a "national security crisis," a description that even some people in his own party reject.In response, a broadcast network executive said "time has been requested for 9 p.m. Networks are deliberating."The broadcasters have been known to resist presidential requests for air time for a variety of reasons, including the perceived urgency of the subject and the popularity of the shows that would be interrupted.With Trump, there were other factors to consider, including his record of deception and his tendency to ramble off script in long speeches.Many Trump critics posted messages on social media urging the networks not to air an address that could be filled with falsehoods. Some said that a prominent Democrat should be given equal time. It is unclear if any sort of Democratic rebuttal is in the works.With all that in mind, network newsrooms were abuzz with speculation about what the broadcasters would decide, since it was sure to be controversial either way.CBS was the first of the broadcasters to say it would go ahead and carry the address. Then NBC, ABC and Fox broadcast network said the same. There's no word on a decision from PBS yet.There is precedent for broadcast networks declining to air a presidential speech. In 2014, ABC, NBC, and CBS declined to carry an 2119

Tensions were running high outside of the Iraqi Consulate in Southfield, Michigan, Tuesday afternoon as it opened its doors to people who want to write and send condolences in the death of Iranian General Qasem Soleimani. Police were on the scene, protesters were too. There was no trouble in sight.The decision to honor the men labeled by the United States as terrorists caused the tension. Several people who are Trump supporters showed up with "Make America Great Again" hats and said they wanted their voices heard.The Consulate was open Tuesday from 2 to 5 p.m. and will be again tomorrow during the same hours. The country of Iraq ordered the Consulate here to open the doors and open a register of condolences. This article was written by Jim Kiertzner for 776