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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

CLEVELAND, Ohio -- After Ohio Gov. Mike DeWine tested positive for COVID-19 earlier on Thursday, he announced on Twitter later on Thursday that he, his wife Fran, and his staff all tested negative. DeWine took a rapid test for COVID-19 as part of the standard protocol to greet President Donald Trump on the tarmac at Burke Lakefront Airport in Cleveland. DeWine’s office said the governor had no symptoms at the time. On Thursday afternoon in a news conference from his house, DeWine said that other than a headache, he was feeling fine. As part of the standard protocol to greet President Trump on the tarmac in Cleveland, I took a COVID test. I tested positive. I have no symptoms at this time. I’m following protocol and will quarantine at home for the next 14 days.— Mike DeWine (@MikeDeWine) August 6, 2020 Upon returning home, DeWine's staff tweeted he took a "PCR" test, which is considered more accurate for the virus. The test administered by the White House, DeWine's staff says, "represent a new technology to reduce the cost and improve the turnaround time for COVID-19 testing, but they are quite new.""The PCR test is known to be extremely sensitive, as well as specific, for the virus," DeWine's staff added. "The PCR tests for the Governor, First Lady, and staff were run twice. They came back negative the first time and came back negative when they were run on a second diagnostic platform."We feel confident in the results from Wexner Medical Center. This is the same PCR test that has been used over 1.6 million times in Ohio by hospitals and labs all over the state."DeWine's staff said he plans to take a follow-up test on Saturday to confirm he is negative for the virus.Lt. Gov. Jon Husted also took the COVID-19 test Thursday as part of the protocol to greet the president. He has tested negative, according to his office.This story was originally published by Kaylyn Hlavaty at WEWS. 1918

Conditions on a breeder's property during an animal rescue operation near Nashville were so toxic that the leader of the rescue team nearly died from ammonia poisoning.Scotlund Haisley, the founder of Animal Rescue Corps, led a team along with sheriff's deputies to the home of a breeder. It was called Operation Noah's Ark.They rescued 150 animals from horrible conditions - conditions that were so bad, Haisley was poisoned by fumes and needed a blood transfusion to survive.Haisley wasn't feeling well, but he was still up and around two days later giving a tour of the shelter."This is what it takes to care for 150 animals. All of these volunteers," said Haisley pointing to his team.Moments later, he became violently sick.ARC has made hundreds of rescues over the years, almost all of them are in deplorable conditions.Yet, this one was in many ways the worst and most dangerous. Inside the structures, Haisley found an unbelievable amount of feces and urine, which produced the highest ammonia levels he'd ever encountered. He still went in."The animals were in there. They were suffering greatly. We had to get them out," said Haisley.Free from that toxic environment, the animals immediately began getting better, but Haisley got worse."Extreme nausea, couldn't hold food or beverages down and very exhausted," Haisley said describing his symptoms.Haisley talked to us later by phone after his release from the hospital for what turned out to be acute ammonia poisoning which required a massive blood transfusion. Doctors told him he nearly died."I've experienced ammonia before. This is a whole new experience for me," said Haisley.However, it won't change his mission. The experience made Haisley even more determined to rescue animals.He now knows, more than ever, that no living creature should ever live in such conditions.Experts say the toxic fumes found at some deplorable sites where animals are rescued can be comparable with those found at a meth lab.Haisley says crews often will wear oxygen masks, but now for extreme cases, they are looking to buy some protective full-body suits. 2187

CINCINNATI, Ohio — A settlement has been reached after a police officer used a Taser on an 11-year-old girl while working an off-duty detail at a Kroger in Southwest Ohio.The City of Cincinnati and Kroger have agreed to pay the family of Donesha Gowdy 0,000 to settle the claim of excessive force, according to a news release from family attorney Al Gerhardstein.Donesha had been shoplifting from the Kroger on Aug. 6 when Officer Kevin Brown, who was on security duty, ordered her to stop. She didn't. The officer fired his Taser as she walked away. One probe struck her at the base of her spine; the other hit between her shoulder blades.The incident prompted an apology from Cincinnati Mayor John Cranley and a promise from Vice Mayor Christopher Smitherman to review Cincinnati Police Department’s protocol on Tasers.Cincinnati Police Chief Eliot K. Isaac promised “a very thorough review” of Brown's actions, as well as the department’s use-of-force policies as they pertain to juvenile suspects. He said he's "extremely concerned when force is used by one of our officers on a child of this age."Smitherman, along with the girl's mother, also say the policy needs to change. The settlement did not include plans to change police department policy, and it must be approved by probate court.Donesha wrote this apology to Kroger: “I Donesha Gowdy is writing this letter to apologize to the Kroger company … to say I’m sorry for stealing from the store in will not do it again.”WCPO television station in Cincinnati has reached out to the City of Cincinnati and Kroger for comment. 1629

COLORADO SPRINGS, Colo. -- While a woman seen repeatedly doing her business in a Colorado Springs neighborhood continues to elude capture, Toilet paper company Charmin is offering up a deal that she may not want to pass.The company offered the runner, dubbed the "Mad Pooper" by neighbors, a year's supply of toilet paper if she turned herself in. Charmin tweeted the offer hours after the story went viral across the globe. 437