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JINAN, Oct. 24 (Xinhua) -- Chinese scientists have made a breakthrough that could lead to more effective treatments for leprosy.A team from Shandong Provincial Institute of Dermatology and Venereology in east China has identified two new risk variants near IL23R and RAB 32 genes that are responsible for the disease, according to a report published online Monday in the scientific journal Nature Genetics.Knowing that the two gene variants influence susceptibility to leprosy could allow doctors to diagnose the disease in sufferers earlier in its outset, as well as to develop new treatments. A genetic database could now be built up to predict those people particularly susceptible to leprosy, said Zhang Furen, the leader of the research team.The study involved more than 10,000 samples being taken from leprosy sufferers and healthy test subjects and analysed.Leprosy is a chronic nerve-killing disease that leads to problems with patients' skin, feet, hands, legs and eyes. More than 200,000 newly-contracted leprosy cases are reported worldwide every year, and China has around one tenth of the world's sufferers.
YICHANG, Oct. 30 (Xinhua) -- China's Three Gorges Dam on Sunday reached its designed highest mark, the second time for the world's largest water control and hydropower project to run at full capacity.The water level hit 175 meters at 5 p.m. after storing water for nearly two months from the water level of 152 meters, said an official with the China Three Gorges Project Corporation (CTGPC), the developer of the project.A dozen hydropower turbo-generator units started operation on Sunday, generating power capacity of 8.2 million kw, said the official.The dam in central China's Hubei Province completed its first full-capacity test last October.Operating at full capacity should give full play to the dam's functions of generating hydroelectric power, delivering water to the lower reaches to alleviate spring droughts, and containing water from summer flooding, as required by the State Flood Control and Drought Relief Headquarters.The Three Gorges Project was launched in 1993 with a budget equivalent to 22.5 billion U.S. dollars.So far, monitoring shows the dam is operating smoothly.

BEIJING, Nov. 11 (Xinhua) -- Senior leader Zhou Yongkang on Friday urged Chinese judiciary and police officers to "creatively" handle cases in a bid to achieve a balance between law enforcement and social sensitivity.Zhou, secretary of the Communist Party of China Central Commission for Political and Legislative Affairs, made the remarks at a meeting with Zhan Hongli, a veteran female judge of a juvenile court in southern Fujian province.Zhou urged judiciary workers and police to learn from Zhan, who has not received a single complaint of misjudging in nearly 500 criminal cases involving 1,140 juveniles.In her 27 years of work in courts, she cared for the juveniles like a mother and creatively worked out a feasible judgment method for handling cases of young offenders, said Zhou, who is also a member of the Standing Committee of the Political Bureau of the CPC Central Committee.Zhan addressed saving the juveniles with education and persuasion as well as helping them go back to school and reintegrate into society, an approach which had positive benefits and won favorable comments from the young offenders' families and the public, Zhou said.Zhou also urged judiciary and police officers to enhance the quality of law enforcement and case handling by adhering to principles of fairness and transparency, so as to better settle conflicts among the people.
SANTO DOMINGO, Sept. 30 (Xinhua) -- Haitian health authorities on Friday said the number of deaths caused by cholera increased to 6,435 in the Caribbean country since October 2010.The Haitian Health Ministry said the number of people infected with cholera almost reached half a million, although the ministry repeated the epidemic was decreasing.The report said 455,727 people had been treated due to cholera, and 242,205 had to be hospitalized.The western province of Artibonite suffered the plague most with 1,196 deaths. The southwest province of Nippes registered the smallest death toll of 181.Meanwhile, in the Haitian capital Port-au-Prince, 221 people have been killed since October 2010 when the epidemic first broke out in central Haiti.The epidemic is supposedly due to the spill of dregs from a Nepalese camp, which is part of the UN Stabilization Mission in Haiti (MINUSTAH).The Dominican Republic, a country neighboring the island country Haiti to the east, has also been suffering the disease since November 2010, which has killed at least 135 people there.
WASHINGTON, Dec. 7 (Xinhua) -- Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells' ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) -- a protein that promotes synaptic plasticity -- and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals."These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging," said Xie, who led the study. "Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer's disease," she added.
来源:资阳报