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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

BEIJING, Sept. 30 (Xinhuanet) -- Miners, construction workers and people in hotel and food service industry are most likely to smoke in the U.S., according to new research finding.The finding was contained in a report released Thursday by the U.S. Centers for Disease Control and Prevention (CDC).According to the finding, miners and people in hotel and food service have a cigarette smoking rate of 30 percent, followed closely by construction workers' 29.7 percent.Both rates are much higher than the average smoking rate of 19.6 percent among all U.S. working adults.Workers in the education services industry have the lowest smoking rate, with 9.7 percent, followed by the 10.9 percent of workers in company management, the report said.Low education levels are a factor in high smoking rates, along with poverty and gender, said Ann Malarcher, senior scientific adviser at the CDC."Although some progress has been made in reducing smoking prevalence among working adults," the report wrote, "additional effective employer interventions need to be implemented."Smoking kills an estimated 443,000 each year in the U.S., costing about 193 billion U.S. dollars annually in direct health care expenses and productivity loss.

NANJING, Dec. 20 (Xinhua) -- Chinese Premier Wen Jiabao has called for the country to maintain confidence that it can weather challenges amid a "complicated and tough" outlook of economic development."As in 2008, we are now encountering difficulties which can be overcome through hard work," Wen said during his tour to eastern Jiangsu province on Sunday and Monday.Elaborating on the grim situation, Wen said the growth of China's exports has been slowing and the pace of the slowdown has accelerated, especially in the past three months. Meanwhile, the profit margin of the country's manufacturing industry has been squeezed and some enterprises have even fallen into the red.Chinese Premier Wen Jiabao (C) talks to staff members in a small loan company for rural areas in Suzhou National New & Hi-Tech Industrial Development Zone in Suzhou City, east China's Jiangsu Province, Dec. 19, 2011. Wen Jiabao made an inspection tour in Jiangsu on Dec. 18 and 19. He noted that the country is also facing shrinking external demand, rising costs and pressure from both slowing economic growth and high inflation, which makes macro-economic regulation more difficult.Despite emerging challenges, however, the current momentum of China's economic development is "generally good," Wen said.China's economic growth has been slowing all year but remains above the global average. Its GDP growth slowed to 9.1 percent in the third quarter from 9.5 percent in the second quarter and 9.7 percent in the first quarter.To tackle the challenges, Wen said the country will boost domestic demand while stabilizing external demand and keep its export policies such as export tax rebates "basically stable" in the coming year.Efforts should also be made to enhance domestic enterprises' competitiveness, promote the transfer of industry to the country's western regions, and develop the international market, especially in emerging economies, he said.He said China will stick to, and further improve upon, the opening-up policy and welcome foreign enterprises to invest in the country, adding that the country will protect intellectual property rights and implement a fair and open bidding approach in terms of government procurement.Wen also demanded efforts be made to encourage private investment in sectors such as railways, public facilities, finance, energy, education and health-care.Furthermore, he urged banks to take concrete action in better serving the real economy and asked financial institutions to enhance support for enterprises while improving management in order to control the capital bubble and prevent risks.Wen said the southern parts of Jiangsu should engage in a comprehensive development strategy to build the province into a forefront of the country's opening-up drive.

BEIJING, Oct. 27 (Xinhuanet) -- Virginia M. Rometty, 54, will succeed present IBM CEO Sam Palmisano to be the next chief executive at the start of 2012, the company announced Tuesday.This is unprecedented in the New York-based company's 100-year history, because Rometty, a senior vice president of IBM, will be its first female CEO.Since joining the company three decades ago, Ms. Rometty has contributed a lot to the giant I.T. Company.After graduating from Northwestern University with an undergraduate degree in computer science, she entered the company in 1981 as a systems engineer. In virtue of outstanding performance, she was quickly promoted to management.For the following 20 years, she worked with clients in banking, insurance, and telecommunications, to name a few.In 2002, Rometty caught Palmisano's attention when she helped integrate the 3.5 billion dollar acquisition of the big business consulting firm PricewaterhouseCoopers Consulting, IBM's largest deal ever at the time.Then she became senior vice president of the group and group executive for sales, marketing and strategy in 2009. Under her leading, the business in overseas emerging markets including China, India, Brazil and several African nations, has increased sharply.New York Times reported that such markets now accounted for 23 percent of IBM.’s revenue, up from 20 percent when she took over.“Ginni got it because she deserved it,” Mr. Palmisano told the New York Times. "Ginni" is an informal first name used by her friends and colleagues.The selection of Rometty for chief executive will make her the 17th female CEO in the Fortune 500 on the following January. Other prominent women who play the same role as Rometty include Indra Nooyi of PepsiCo, Ellen J. Kullman of DuPont, Meg Whitman of Hewlett-Packard, and so on.

ULAN BATOR, Dec. 1 (Xinhua) -- Mongolia will continue to curb the spread of HIV and strive to maintain a low prevalence of the AIDS epidemic, a government official said Thursday.Gansukh Battulga, an official with the National Committee on AIDS, told Xinhua that Mongolia is currently an HIV low-prevalence country with a total of 99 people, 15 of whom have died, infected with the virus that causes AIDS."Among the 99 HIV infected cases, 81 percent are men, and the remaining 19 percent are women," Battulga said. "Among the male infected cases, 83 percent belong to MSM (men who have sex with men) group while sex workers account for 54 percent of the female infected cases."The official said the government has launched a variety of programs and tasked the National Committee on AIDS to coordinate all organizations in fighting the epidemic.According to a National Strategy Plan for 2010-2015, Mongolia will strive to maintain its current low HIV-prevalence rate of below 5 percent in the most-at-risk population.