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SAN DIEGO (KGTV) — The back-to-back announcements of promising clinical trial results from Pfizer and Moderna may usher in a new era for vaccine technology.Both companies have candidates that rely on a new kind of vaccine strategy: RNA. Preliminary data show both candidates are more than 90 percent effective.On the surface, the vaccine candidates look like any other you’ve taken. They work by training your body to build up defensive weapons against a virus, like antibodies and T-cells.But instead of training your body by introducing a killed virus or a fragment of a virus, the vaccines from Moderna and Pfizer introduce a set of instructions called messenger RNA enclosed in a little blob of fat.“The key concept of RNA is that they’re messages, and they’re meant as short-term messages,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.Crotty said there are 5,000 to 10,000 messages within a cell at any given time.Once administered, the mRNA in the vaccine instructs some of your cells to make the coronavirus’ signature spike protein. The spike protein on the surface of the coronavirus allows it to infiltrate and hijack cells.Even though the spike protein is just one of about 25 genes the virus has, preliminary results from the clinical trials suggest it is enough material to train the immune system without making the recipient sick.Crotty likened the process of training the immune system to spotting a sedan. If the coronavirus is a car, the spike protein might be the door.“There's no way that car door could turn into a whole car, but it's enough of a piece of a car for your immune system to recognize that car if it saw it again,” he said.Scientists started by sequencing the virus’ DNA from a sick patient, then encoding that genetic sequence into an mRNA instruction molecule that can be read by the manufacturing part of cells.From there, Dr. Crotty said it’s a bit like the messenger app Snapchat.The mRNA gets injected into the body, sending temporary instructions to your cells that last for a while, then disappear. mRNA does not genetically modify cells, he stressed.“They’re around as messages for some period of time and then they go away, and the cells get back to their normal job of reading their own messages instead of reading the messages you’re injecting in the vaccine,” he said.The concept has been around since the 1990s, but there are currently no RNA vaccines on the market for any pathogen, so Dr. Crotty said it’s hard to estimate how long their protective effects will last.Some vaccines offer a lifetime of protection, like the measles vaccine. Others offer decades of protection. The flu vaccine only lasts about six months.Dr. Crotty said the length of protection depends on how fast the virus mutates and how long the immune cells survive in the body.But even if the COVID-19 vaccine turns out to need an annual update, he’s optimistic. The best feature of RNA vaccines is that they can be quickly reprogrammed.Both Moderna and Pfizer are still in their Phase 3 trials, but they expect to finish them by December. Together, they estimate they’ll have enough doses for about 35 million people by the end of this year, primarily for healthcare workers and high-risk individuals. 3250

SAN DIEGO (KGTV) -- The Carte Hotel in the heart of Little Italy is not nearly as full as it could be.It had been open just a few months before the pandemic hit, "We had a great start until March and the virus started showing up," said general manager Henri Birmele.Like many other hotels in California, The Carte is only allowed to book rooms for essential workers.But staff is preparing for when the Governor says they can fully reopen. "We have sanitizers on every floor, every piece of equipment that's available we have throughout the building to take care of team members and hotel guests," Birmele said Common areas will be sanitized every hour, the restaurant and rooftop bar will be spaced out to make it easier to social distance, valet service won't be available, there will be at least 12 hours and a deep clean between when one person checks out and another checks in and room service will leave orders at the door instead of bringing them in. The Carte is hoping to ease people back into hotels by encouraging "staycations" and planning to offer locals discounts and deals. "How people react, I don't know. I think time will tell. I think we have all the precautions in place to make sure that everyone is safe during their stay," said Birmele. 1270

SAN DIEGO (KGTV) - The California Department of Alcohol Beverage Control (ABC) made changes making it easier for businesses to sell alcohol.This week, the agency made major changes allowing restaurants to sell beer, wine and pre-mixed drinks or cocktails for pick-up or delivery as long as it is sold with food and has a secured top.While the changes will help many business owners, some San Diego bar owners say the ABC needs to take a look at other parts of the law as well."I know my seven employees are hurting, and I am too," said Tony Raso of Bar Sin Nombre.Raso said when the statewide order came down to close, he did. He has bar food he can sell, but where his problem comes in is with the beer that's already on tap."My struggle has been with all of the draft beer," he said. "We're primarily a draft house, and most of my money is in draft inventory."According to the ABC's website, restaurants "selling beer, wine, and pre-mixed drinks or cocktails for consumption off the licensed premises may do so when sold in conjunction with meals prepared for pick-up or delivery. Any such alcoholic beverages must be packaged in a container with a secure lid or cap and in a manner designed to prevent consumption without removal of the lid or cap."Raso said while he appreciates the relaxed restrictions, he's still sitting on at least ,000 in kegs he can't sell."Allow us to repackage the beer from the taps," Raso said. "Allow us to drain the inventory that we already have tapped that's going to spoil and allow us to create some sort of revenue."In a statement to 10News, a spokesperson for the ABC wrote 1623

SAN DIEGO (KGTV) - The census count impacts everyone living in the United States, from determining how much federal money cities and counties receive to how many representatives states get in Congress. Everyone living in the country regardless of age, race, and citizenship status is asked to fill the survey out. But San Diego and Imperial Counties are notoriously difficult to get an accurate count, the second most challenging region in the entire country. For the 2020 census, over 100 community organizations and civic groups in San Diego are working together to reach "hard to count" populations.“Some of the ethnic groups are the ones that are hard to count, such as the African Americans, the Hispanic, Asian Pacific Islanders, as well as immigrant and refugee populations are really hard to count," said Nancy Sasaki, President & CEO of United Way of San Diego County.United Way of San Diego County is leading the Count Me 2020 campaign. Sasaki went on to say veterans, homeless people, and children are often left out too. The county was awarded two major contracts, totaling .22 million, to coordinate Census 2020 outreach for hard to count populations in San Diego and Imperial Counties.The Supreme Court will rule whether the controversial citizenship question will be added to the census, a decision is expected by June. 1349

SAN DIEGO (KGTV) -- The mayor of Temecula has announced his resignation after facing raging criticism over an email stating he didn't “believe there’s ever been a good person of color killed by a police officer." James "Stew" Stewart's comments went viral June 2 and drew a firestorm of calls for his resignation and threats of protests. Stewart made the racist remark in a reply to a constituent "concerned about our police officers and their sensitivity training.""As you know the City of Temecula does not have its own Police Department," Stewart said in his email. "We contract with Riverside County Sheriff's Department.""And I don't believe there's ever been a good person of color killed by a police officer," said Stewart.Stewart posted a copy of the email on his own Facebook page explaining that he is dyslexic and uses voice text, and that he published the note without proofreading what was recorded."I may not be the best writer and I sometimes misspeak, but I am not racist. I deeply regret this mistake and I own it, entirely. I am truly sorry," Stewart said in his resignation letter posted on Facebook late Thursday night.Stewart's comments brought tension to the small tourist destination city during a time in which the nation is seeing daily demonstrations and protests against police killings and racism. A Change.Org petition has started circulating demanding that city officials acknowledge that "systemic racism and police brutality exist in Temecula and the need for reform and consequence."Temecula, a city of about 115,000 residents in Riverside County, is located about 85 miles north of San Diego. The area is a popular Southern California destination known for its dozens of wineries, hot air balloon rides, and festivals similar to Northern California's wine country.Stewart's biography remains published on the city's website. It says that Stewart moved to Temecula in 1991 with his wife and three children from Oswego, Illinois. According to his page, the businessman owns eight barbershops in the area and that he has worked as a dentist during mission trips to Haiti pulling teeth and conducting eye glass clinics in Ethiopia.The city has not released plans to fill his vacant seat. He was elected to a four-year term in 2016.Here is Stewart's resignation announcement:Temecula StewCity of Temecula, I hear you, I agree with you, and I am deeply sorry. I owe everyone an apology including our citizens of all backgrounds and ethnicities, City staff, and my respected colleagues on the City Council. You have every right to be hurt and offended. My typos and off-the-cuff response to an email on a serious topic added pain at a time where our community, and our country, is suffering. I may not be the best writer and I sometimes misspeak, but I am not racist. I deeply regret this mistake and I own it, entirely. I am truly sorry.I understand that even my sincerest apologies cannot remedy this situation. Because actions speak louder than words, I will step down as your Mayor and City Council Member effective immediately. It has been a true honor to serve this great City and its citizens. My love for Temecula and its residents is beyond expression.”Mayor Pro Tem Maryann Edwards states, “Stew is a hard-working and honest man, and the City accepts his resignation. Temecula is poised to close this chapter, and continue our long-term commitment to preventing racial injustice in any form. On this day of Mr. George Floyd’s memorial service, and on behalf of my council colleagues, the City of Temecula offers our prayers and heartfelt condolences to his family.” 3623