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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).
SAN FRANCISCO, June 13 (Xinhua) -- Google on Monday confirmed that it had signed an agreement to buy Admeld, an on-line advertising optimization firm, in a deal seen as the Internet search giant's latest move to bolster its on-line display ad business.Admeld, launched in 2007 and headquartered in New York City, has developed a service that can help on-line publishers manage their ad space more efficiently and profitably.Admeld now has more than 500 customers worldwide, among them are FOX News, IDG TechNetwork, Discovery and The Weather Channel, according to information posted on its website."By combining Admeld's services, expertise and technology with Google's offerings, we're investing in what we hope will be an improved era of flexible ad management tools for major publishers, " Neal Mohan, Google's vice president of display advertising, said in a blog post announcing the deal."We believe that this investment will be an important step to help on-line publishers, and will further improve and grow the display advertising industry as a whole," Mohan noted.On-line display ads usually appear in forms that consist of images and may be interactive. According to the Interactive Advertising Bureau, a U.S. trade association, display-related on- line ad revenue in the United States totaled nearly 10 billion U.S. dollars in 2010.Financial terms of the deal were not disclosed by the two companies. TechCrunch, a technology blog site, has reported that Google paid around 400 million dollars.

BEIJING, July 25 (Xinhuanet) -- Apple is planning a third, even larger Shanghai store, as well as dozens of other stores throughout China, to cope with huge crowds at its flagship store and a branch, according to media reports Monday.Apple says its Chinese outlets -- two in Beijing and two in Shanghai -- are the four most heavily trafficked Apple stores in the world. They also generate the most revenue. Apple’s push into China shows the depth of the country’s fast-growing economy, and shows that with products not so easy to counterfeit, Chinese consumers are willing to pay a premium.For the first three quarters of Apple’s fiscal year, revenue in China and its Taiwan, Hong Kong was 8.8 billion dollars -- six times that of a year earlier. China has become the second-largest market, after the United States, for apps that run on the smartphone and tablet, according to Distimo, a Dutch company that tracks the popularity of apps.In addition, Apple has been eager to team up with state-run telecom companies, which looks after mobile phone subscriptions.
BEIJING, May 31 (Xinhuanet) -- European anti-trust regulators Monday launched in-depth probes into takeover bids for two Asian companies by two American peers in the computer hard disk drive sector, media reports said Tuesday.U.S.-based Seagate Technology has said it wants to buy Samsung Electronics Co's loss-making hard disk drive unit for 1.4 billion U.S. dollars -- a deal that will give Seagate access to Samsung's NAND-type flash chips for its solid-state drive products.Western Digital plans to purchase Hitachi Ltd's hard disk drive business for 4.3 billion dollars to give it an edge in developing next-generation storage technology.The two planned acquisitions in a sector with just five manufacturers worldwide have raised concerns in Brussels, the European Commission said."Hard drives are the backbone of the digital economy," said EU competition commissioner Joaquin Almunia in announcing the investigation."The sector has already experienced significant consolidation and the proposed acquisitions will further reduce competition."Brussels officials have until Oct. 10 to decide what action if any they will take.
BEIJING, Sept. 27 (Xinhuanet) -- Last-minute preparations for the launch of the Tiangong-1 spacecraft began at the Jiuquan Satellite Launch Center on Monday, meaning the vehicle can soon embark on a mission that will eventually have it dock with a spaceship, according to the center.That feat, if carried out successfully, will mark the completion of China's first rendezvous and docking mission.At the launch site on Monday afternoon, crews were putting in place pipes and cables that will be used to inject fuel into the rocket that will carry Tiangong-1 into outer space.Without complications from the weather or other causes, the Long March II-F rocket will lift off from the launch center on Thursday or Friday, taking the Tiangong-1 with it, according to the Xinhua News Agency.Despite the preparations, space experts said carrying out the plan still comes with many risks. They explained that the spacecraft and much of the other equipment being used is new and has not been tried on an actual mission."Tiangong-1 is a brand new spacecraft designed by China and is bigger and heavier than the Shenzhou spaceships China had developed as a means of transporting astronauts from the Earth to space," said Yang Hong, chief designer of Tiangong-1.In a vertical position, the Tiangong-1 looks like a cigar standing 10.4 meter tall, a height equal to that of a three-story building. It weighs 8.5 tons and has a maximum diameter of 3.35 meters, a dimension shared by its launch vehicle, he said.In comparison, the Shenzhou spaceship stands shorter, at nearly 9 meters, is slimmer, having a diameter of less than 3 meters, and weighs less.In another difference, the Tiangong-1 is composed of two modules rather than the three that had made up the Shenzhou spaceship. Of the Tiangong-1's two primary components, one is an experimental module that contains a place that astronauts can live and work in on future missions. It is also equipped with a docking port.The other chief component, a resource module, will provide the craft with power.Astronauts on Tiangong-1 will have 15 cubic meters of space to move in, "much more than they had in the Shenzhou spaceship", Yang said.Inside the spacecraft are two sleeping sections with adjustable lighting systems, exercise equipment, entertainment systems and visual communication devices, he said.Hou Xiangyang, who helped design Tiangong-1, said: "The sleeping section is big enough for a 1.8-meter-tall man to sleep in. An astronaut can adjust the light as he likes."In space, Tiangong-1 will fly in a horizontal position. A paint scheme inside will help the astronauts aboard maintain their sense of direction; the module's inner walls will be in two colors, one commonly associated with the sky and one with the ground."This will help astronauts avoid feeling as if they are standing upside down in the microgravity environment," he said.Yang said the Tiangong-1 spacecraft is expected to stay in orbit for two years and rendezvous and dock with three different spaceships. Beyond the Shenzhou VIII, ships named Shenzhou IX and Shenzhou X will embark on similar missions; at least one of the two is to be manned.Before astronauts climb on board Tiangong-1, the conditions inside its experimental module will be adjusted to ensure they can live in an environment that contains enough oxygen, moisture and heat to be safe.Tiangong-1 was originally scheduled to be launched into a low orbit around the Earth between Sept 27 and 30. The earlier days were removed as possible launch dates, though, after forecasters predicted a cold air mass would move into the area containing the Jiuquan Satellite Launch Center.To ensure the spacecraft and Long March II-F carrier rocket are ready for launch, a full ground simulation was conducted on Sunday afternoon.
来源:资阳报