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New studies confirm that multiple types of steroids improve survival for severely ill COVID-19 patients, cementing the cheap drugs as a standard of care.An analysis of pooled results from seven studies found that steroids reduced the risk of death in the first month by about one-third compared to placebo treatment or usual care alone in these seriously ill patients who needed extra oxygen.The work was led by the World Health Organization and published Wednesday by the Journal of the American Medical Association.Based on the results of the studies, the WHO has made two recommendations. The first, it says a strong corticosteroid therapy for 7 to 10 days should be used in patients with severe or critical COVID-19. The second, this therapy should not be used in patients with non-severe COVID-19, because it may increase the risk of death.“In contrast, in patients with non-severe COVID-19, based on data from 1,535 patients in one study, systemic corticosteroids may increase the risk of 28-day mortality,” researchers wrote.Compared to other treatments for COVID-19, these types of steroids are generally low cost, easy to administer and readily available across the globe.“Dexamethasone and prednisolone are among the most commonly listed medicines in national essential medicines lists; listed by 95% of countries. Dexamethasone was first listed by WHO as an essential medicine in 1977, while prednisolone was listed 2 years later,” the WHO wrote.The WHO added that clinicians should exercise caution in use of corticosteroids in patients with diabetes or those who are immunocompromised and could become severely ill do to COVID-19. 1651

NEW YORK — Prosecutors on Tuesday charged 18 alleged gang members — including rapper Casanova — in connection with various racketeering, murder, narcotics, firearms and fraud offenses, officials said.Prosecutors added that Casanova is the only one of the 18 — who were allegedly a part of the Untouchable Gorilla Stone Nation gang — that was not in custody as of Tuesday. The FBI is still searching for the rapper, whose real name is Caswell Senior, and the agency believes he may be in the Atlanta area.Officials charged Brandon Soto in connection with the Sept. 21 murder of a 15-year-old minor in Poughkeepsie. The accused individuals also allegedly defrauded COVID-19 economic assistance programs, acting U.S. Attorney Audrey Strauss said."Because of that, communities across the Southern District (of New York) – from Poughkeepsie to Peekskill to New York City — suffered," Strauss said.The alleged crimes span a wide swath of New York: on June 12, Naya Austin, Dezon Washington and Jordan Ingram allegedly robbed a rival drug dealer at gunpoint in Peekskill; on July 20, Stephen Hugh allegedly shot at rival gang members in New Rochelle and on Aug. 28 of 2018, Brinae Thornton allegedly shot at a rival gang member in Brooklyn.Casanova is currently signed to Roc Nation, the label founded and operated by Jay-Z, in 2008. He released his first studio album in 2019 and has collaborated with artists like Jeremih, Chris Brown and DMX.This story was originally published by Aliza Chasan on WPIX in New York City. 1523

NILES, IL — Most would agree 2020 has been a tough year. For one custom toymaker, though, it has been fueling his niche business. Part Santa’s elf, part satirist and a kid at heart, Dan Polydoris' home in Niles, Illinois is a shrine to toys.But for the avid toy collector, it wasn’t enough to just collect. A decade ago, he decided to create.“Most of the time, for figures, I start with some kind of existing figure,” he explained. “I have parts upon parts.”Death by Toys was born out of that need. But his re-purposed action figures and throwback novelties aren’t just toys, they’re often imbued with scathing social commentary.“I like a good jab at a fragile male ego as much as I love just a forklift driver who looks sexy or something like that,” said Polydoris.Everything is painstakingly made by hand. Nothing is mass-produced, which means everything is made in small batches or even as one-of-a-kind creations.Items like the limited edition "Karen" figure sell for 5. A package of air is sold as "100% Genuine Thoughts & Prayers."Last month after a fly landed on Mike Pence’s head during the vice-presidential debate, Polydoris offered up 50 "Mike Pence Head Fly" toys. They sold out almost immediately.“We're just all the worst. And we all were like, 'That fly is the hero we needed.’”In 2016, horror filmmaker Eli Roth gifted one of Polydoris’ Maniac-inspired bloody scalps to writer Stephen King.His toy-making handiwork has even been featured on The Tonight Show with Jimmy Fallon.“I will say the generally positive response to the garbage that I make has been surprising and has been a pleasure and a nice little treat," the toy maker said.But Polydoris says it’s not the mass appeal he’s interested in and he knows his edgy brand of "art" may not be for everyone.“The truth is anything that has a point of view will have someone that doesn't like that,” he said. “So, that's just the deal.”Still, in a year like 2020 where his bestselling items include the coronavirus and a garbage fire, Polydoris says his custom collectibles may just be the brand of humor we all need right now.“Someone who might have at the beginning of the year been like, ‘No thank you,’ but now, after a year of living alone and growing a beard down to here, you know we're all kind of pushed to the edge a little bit. So, I think that that kind of stuff speaks to all of us right now.” 2392

NEW YORK -- A time of year with so much light and happiness feels a bit different this year.“Oh I thought Christmas was canceled... Are you saying it’s still on?” New York sculptor Jim Rennert said.Rennert says humor is what gets him through difficult times, like when he had a bike accident.“I broke my collarbone, separated my shoulder, took me 45 minutes to get up," Rennert said. "I was chuckling on the ground about it; that’s how I deal with stress.”He hopes to bring that humor to others this holiday season through his work.“Bringing a little bit of light, a little bit of levity, having something that people can smile about, even if it’s for a moment as they’re walking down the street and they see one of my sculptures goes a long way right now,' Rennert said.The weekend before Christmas, quite a few of Rennert’s sculptures were installed across New York City.“You can’t go to museums, you can’t go to art galleries freely like you could before – they’re limited on their hours and their attendance – so why not put the work out and allow people to enjoy it on the street,” Rennert said.Each sculpture resonates with people in the business world. He was part of that world as a stockbroker before he found his calling as an artist at the age of 34.“I just went back to what I had been thinking about all those experiences in business that were challenging, and I found out there was an audience for that. I don’t know that anybody had ever done that before," Rennert said.His audience has grown this year as the world has been struggling with a whole new set of challenges. He feels inspired to honor essential workers and connect with people through the mutual feeling of isolation.“One is a guy in a bird cage called "Caged but not Conquered," so I got a figure as if he’s a bird in this cage just waiting to get out,” Rennert said.Rennert says we have to hold onto hope and know that things will get better. He says art in a time of so much despair is one way to bring light to the darkness.“It might make them forget about what’s going on which would be kind of nice for a minute, ya know?”Rennert said. 2128

None of the earthquakes that have been happening in the Imperial Valley are anywhere near the San Andreas fault. They are in the Brawley Seismic Zone - a network of small faults that connect the San Andreas and Imperial faults. Historically largest Brawley event was M5.8— Dr. Lucy Jones (@DrLucyJones) October 1, 2020 332

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