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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.
BEIJING, Jan. 21 (Xinhua) -- Chinese Vice Premier Li Keqiang on Friday stressed the importance that local governments improve management of land and resources, as it remains vital for the stable and relatively quick development of the nation's economy.Li said China faced the difficult tasks of land and resource management as resources are becoming scarce amid the country's quickening industrialization, urbanization, and agricultural modernization.He said the nation must continue preserving arable land. To ensure grain security, China set a "red line" to guarantee its arable land never shrinks to less than 1.8 billion mu (120 million hectares).Chinese Vice Premier Li Keqiang (R) shakes hands with outstanding representatives from local departments in charge of land and resources in Beijing, capital of China, Jan. 21, 2011.Li also called on local authorities to step up efforts to protect valuable mineral resources while using resources more efficiently and in a frugal manner.At the same time, the senior Chinese official said land should be guaranteed for the nation's plan to build 10 million affordable houses for low and middle income people this year.Further, Li urged local authorities to improve work in monitoring and taking precautionary measures against geological disasters to ensure the safety of people's lives and property.
LOS ANGELES, April 7 (Xinhua) -- Using NASA's Galaxy Evolution Explorer (GEE) satellite, U.S. astronomers are hunting for nearby, hard-to-see stars which could very well be home to the easiest-to-see alien planets, it was announced on Thursday.U.S. astronomers are ferreting out the new targets after the glare of bright, shining stars has frustrated most efforts at visualizing distant worlds, NASA's Jet Propulsion Laboratory (JPL) said.So far, only a handful of distant planets, or exoplanets, have been directly imaged. Small, newborn stars are less blinding, making the planets easier to see, but the fact that these stars are dim means they are hard to find in the first place."Fortunately, the young stars emit more ultraviolet light than their older counterparts, which makes them conspicuous to the ultraviolet-detecting GEE," JPL said in a press release."We've discovered a new technique of using ultraviolet light to search for young, low-mass stars near the Earth," said David Rodriguez, a graduate student of astronomy at University of Californian, Los Angeles. "These young stars make excellent targets for future direct imaging of exoplanets."Young stars, like human children, tend to be a bit unruly -- they spout a greater proportion of energetic X-rays and ultraviolet light than more mature stars. In some cases, X-ray surveys can pick out these youngsters due to the "racket" they cause. However, many smaller, less "noisy" baby stars perfect for exoplanet imaging studies have gone undetected except in the most detailed X-ray surveys. To date, such surveys have covered only a small percentage of the sky, according to JPL in Pasadena, Los Angeles.Rodriguez and his team figured that the GEE, which has scanned about three-quarters of the sky in ultraviolet light, could fill this gap.Astronomers compared readings from the telescope with optical and infrared data to look for the telltale signature of rambunctious junior stars. Follow-up observations of 24 candidates identified in this manner determined that 17 of the stars showed clear signs of youth, validating the team's approach, JPL said."The Galaxy Evolution Explorer can readily select young, low- mass stars that are too faint to turn up in all-sky X-ray surveys, which makes the telescope an incredibly useful tool," Rodriguez said in the release.
BEIJING, Jan. 23 (Xinhua) -- Chinese President Hu Jintao's state visit to the United States, during which he reached important consensus with U.S. President Barack Obama on building a cooperative China-U.S. partnership based on mutual respect and mutual benefit, has been closely followed by world media.The visit has drawn "unprecedented" world attention, said Gu Xuewu, director of the Center for Global Studies at the University of Bonn.NEW CHAPTER IN DEVELOPMENT OF CHINA-U.S. TIESCommenting on Hu's visit, which occurred at the beginning of the second decade of the 21st century, Professor Severino Cabral, director of Brazil's China and Asia-Pacific Research Institute, said the visit opened a new epoch for China-U.S. relations.The resumption of dialogue between the world's two major economies, which itself is a significant event, would exert great influence on the new world agenda, and hopefully help eliminate the residual cold war mentality and take bilateral relations to a new era, he said.Chen Kang, professor at Lee Kuan Yew School of Public Policy at the National University of Singapore, said that the joint statement issued by the two sides during Hu's stay -- built upon bilateral efforts to establish a cooperative partnership based on mutual respect and mutual benefit -- is a clear reflection of the two countries' resolution and pragmatic attitude in jointly meeting global challenges.China Press USA, a New York-based Chinese language newspaper, said in an editorial that the two countries' commitment to building an all-round and mutually beneficial, win-win economic partnership, as put in their joint statement, is the greatest achievement that comes out of the meeting between the leaders of the two countries in the economic sphere.Nouvelles D'Europe, a major Chinese language newspaper in France, said in an editorial that Hu's visit yielded fruitful results which are indispensable to world peace and development.In their joint statement, the two countries for the first time defined that China-U.S. partnership is based on mutual respect and mutual benefit. Stable China-U.S. relations contribute to world stability, and a win-win scenario between China and the United States is conducive to a scenario of multi-party-win in a multipolar world, it said.International Daily News, an Indonesian newspaper, said that Hu's visit achieved a historic breakthrough. Their joint statement signaled a new chapter in their "cooperative partnership based on mutual respect and mutual benefit," and Asia is hailing the new orientation of bilateral ties and achievement set up by the leaders of the two countries.