巫山县奈杜美甲加盟电话多少钱(自贡市珂洛丽美甲加盟电话电话多少钱) (今日更新中)

Last year's seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, then, people had inadequate protection against the flu.This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today.This year's flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate professor at the University of Pennsylvania. Add to that, he said, "this could end up being a pretty bad flu season."Still, he said, "our best protection" against severe illness is getting vaccinated with the flu shot we have today.Finding answersEach year before flu season begins, a vaccine is made based on whichever virus strains are expected to circulate. The selected seed strains are distributed to vaccine manufacturers which then produce their formulations and make them available to health care professionals before the season begins.During the 2015-16 season, vaccine effectiveness was 47%, while for the previous 2014-15 season, effectiveness was just 19%, according to the CDC. While the overall effectiveness of last season's vaccine was 42%, it was only 34% effective against the H3N2 viruses that dominated the season.Vaccine effectiveness varies based on how well it matches the circulating virus strains. Sometimes, a vaccine corresponds to the predominant virus yet its effectiveness is still not what scientists would expect. Trying to understand which element of the vaccine failed is difficult.Hensley and his team began their investigation of last year's vaccine by looking at the seed strains that had been distributed to vaccine manufacturers. These seed strains had been propagated in chicken eggs, the common method used today."The sequences of these viruses are available and when we did an alignment to see what the sequence of these vaccines were compared to the viruses that were circulating, it became very obvious that there was this mutation," said Hensley.To see the effects of the mutation, the team next looked at how the immune systems of both animals and humans who'd been inoculated with an egg-based flu vaccine responded to the actual circulating viruses.The antibodies -- immune system proteins that fight invading pathogens -- elicited in both animals and humans failed to bind to and neutralize the flu viruses, Hensley and his colleagues found.While most vaccines in the United States are made in chicken eggs, a small fraction are produced in insects or mammalian cells, Hensley explained. (These are given to people with egg allergies.) He and his team compared immune responses in animals and humans who had received a cell-based vaccine -- in this case, Flublok made by Protein Sciences Corporation."And we found both animals and humans receiving that (cell-based) vaccine had superior antibody responses that could bind and neutralize these circulating H3N2 strains," said Hensley.Making a better vaccine"Most of the infrastructure to produce vaccines in the US is based on chicken eggs," said Hensley. There are good reasons for this, including the fact that egg-based propagation allows manufacturers to quickly produce large quantities of vaccine.While egg adaptations have always been a problem, beginning last year it had become a "huge problem," said Hensley. "As soon as you try to grow this virus in eggs, within a few hours, the virus will acquire this kind of mutation."This is not an easy problem to fix, he said. To produce vaccines in cells means "a very expensive process for companies to just change their overall manufacturing process," Hensley explained. "You can't really do that on the drop of a dime."Meanwhile, the same seed strains used last year are being used this year to make the current vaccine, said Hensley."This year may be especially difficult because, in addition to this egg adaptive mutation which was present last year, there's indication that the H3N2 viruses are actually evolving," said Hensley.Not only will the vaccine be a mismatch with the actual circulating viruses due to egg adaptation but the vaccine could also be a mismatch due to unexpected viral evolution.What kind of flu season is ahead?It's too early to speculate which viruses will become dominant in the United States over the course of the coming flu season, said Hensley, "but it's starting to look like it will be H3 viruses." H3 viruses are influenza A viruses."There are the A group of viruses and the B groups," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. "The A groups are the ones that usually are responsible for large epidemics ... whereas the B flu strains usually smolder along. They always cause illness -- it can be just as severe as the A strains -- but they don't produce large outbreaks."Though last year's vaccine was mostly ineffective in thwarting the flu, it still prevented nearly 30% of hospitalizations that might have resulted, according to CDC calculations. For older adults, that rate was even higher, at 37%. Plus, the vaccine reduced outpatient visits by 42% last season.The CDC advises everyone 6 months and older to get a flu shot, as only injectable flu vaccines are recommended. More than 130 million doses of flu vaccine have been distributed so far this year and flu activity is still low across the nation.It's still early days, but experts believe we may be facing a tough season, and not only because of vaccine concerns.The reason?Australia had a tough flu season this year, with a total of 215,280 laboratory-confirmed cases and 504 flu-associated deaths reported to its National Notifiable Diseases Surveillance System as of October 13, government data show. According to a surveillance system report, adults over the age of 80 and children between 5 and 9 years old have been most affected."In general, we get in our season what the Southern Hemisphere got in the season immediately preceding us," Dr. Anthony Fauci, director of the United States' National Institute of Allergy and Infectious Diseases, said in an interview last month.An "intelligent guess," therefore, is that the Northern Hemisphere, like the Southern Hemisphere, will likely battle more cases of the viral infection, he said, though "with influenza, it is never 100%.""If H3N2 viruses dominate the US flu season again this year, vaccine effectiveness will likely be moderate to low again," said Hensley.Still, he said, everyone should get their annual flu shot."The other components of the vaccine, like H1N1 and influenza B, will likely provide excellent protection," said Hensley. "The vaccine will also likely prevent severe disease and death caused by H3N2 viruses, even though this component of the vaccine is mismatched."  6969

LAS VEGAS (AP) — Trailing by double-digits for the second straight day at the Mountain West Conference tournament, the Nevada Wolf Pack rallied again.But this time against San Diego State and without starter Jordan Caroline, the No. 14 Wolf Pack ran out of gas with seven minutes left Friday night.The Aztecs took advantage.Devin Watson had 20 points and five assists and San Diego State held Nevada scoreless for a late 7:06 stretch a 65-56 victory in the Mountain West Conference semifinals.Jalen McDaniels added 12 points and 10 rebounds for fourth-seeded San Diego State (21-12). The Aztecs will play the Fresno State-Utah State winner in the championship game Saturday at the Thomas & Mack Center."We're playing good basketball right now," San Diego State coach Brian Dutcher said. "What that means for tomorrow, I don't know. And if we do enough right things, we'll give ourselves a chance to make it back to the NCAA Tournament again."San Diego State also had a home victory over Nevada on Feb. 20, but lost to the Wolf Pack in Reno last Saturday."It was not revenge," Watson said. "I feel like every time we match up with Nevada it's going to be a great game and the fans love it. They play hard and they're a competitive team. We actually like playing them."Cody Martin led the top-seeded Wolf Pack (29-4) with 16 points and six rebounds, and Tre'Shawn Thurman had 11 points and 11 rebounds as Nevada awaits word on an NCAA Tournament berth.NO CAROLINECaroline, averaging 17.3 points and 9.6 rebounds, did not play due to an injury."Caroline was held out for precautionary reasons," Nevada coach Eric Musselman said. "It's been a long season. He's got a lingering injury and that's what it is."Dutcher made a few adjustments."Well, obviously, we were a bit surprised when Caroline wasn't in the lineup," he said. "But it's like anything else. It's a wounded animal. We knew they were dangerous anyways."AZTECS MAKE RUN, WOLF PACK RESPONDLeading 34-29 at halftime, the Aztecs kept momentum starting the second half on Watson's consecutive 3-pointers. And after Jeremy Hemsley's basket, San Diego State led 42-29.Nevada responded with an 18-4 run that included Caleb Martin's first point and first field goal, a 3-pointer with 12:01 left. Nevada took the lead on Cody Martin's fast-break layup with 10:02 left."We just hung in there," Dutcher said. "So every time we play them, it's a back-and-forth affair. No matter what kind of run they were on we kept looking at the scoreboard, it was a two-point game. So it wasn't like they ran out on us by 11 points."CALEB IN FOUL TROUBLE EARLYNevada's Caleb Martin committed two fouls in the first 1:04. He did not score in the half, only playing four minutes. There were eight lead changes and the game was tied for 6:17 of the first half before the Aztecs created a little distance at intermission."I had two all-league players not play in the first half. I thought our effort was phenomenal," Musselman said. "I think our record speaks for itself, the body of work in the non-conference, conference play. Unfortunately, we weren't fully healthy tonight."THE BIG PICTURESan Diego State: The Aztecs reached the MWC semifinals for the 12th consecutive season. They are 4-0 against Nevada in neutral-site games. San Diego State has won 23 straight games holding opponents under 60 points. With the 20th win of the season, the Aztecs have reached the mark in 13 of the past 14 seasons.Nevada: The Wolf Pack's 58 wins the past two seasons is their best in team history. The Wolf Pack are 2-4 against Dutcher.UP NEXTSan Diego State: Championship game Saturday night against Fresno State-Utah State winner. 3663

LEXINGTON, Ky. — A car wash in Lexington, Kentucky is offering a wash, a shine, and a scare this Halloween season.Rainstorm Car Wash has transformed its facility into the ‘Tunnel of Terror,’ a family friendly event that will be held every Friday and Saturday night until Halloween.“With all the COVID stuff, a lot of haunted houses weren't open or anything like that,” said Reese Kemp, the manager of Rainstorm's Lexington location. “So we figured let's have a great time.”When Gov. Andy Beshear unveiled his plan for a safe Halloween, he urged people to avoid haunted houses, citing the likelihood that COVID-19 could spread in such tight quarters.Those concerns don’t really apply to a haunted car wash."When you're in your car, you don't have to worry about getting within six feet,” Kemp notes. “Your windows are up the entire time, the [employees] can have a blast and you don't have to worry about coming into contact or spreading or anything like that.”While your car is getting washed, people will notice employees dressed up as scary characters, trailing the cars to give families a fright.As part of the event, Rainstorm has partnered with local food banks. Drivers who bring a canned food item will receive five dollars off their wash.This story originally reported by Mike Valente on LEX18.com. 1315

LEXINGTON, Kent. - Wednesday is National Working Parents Day – a time to recognize and appreciate guardians who balance their work and home life.It’s a task that has been especially challenging during the coronavirus pandemic. Since the school year has started back up, many now have to juggle work while overseeing at-home learning.Michelle Martel, a professor and the director of clinical training for the University of Kentucky’s psychology department, says it’s OK for parents to feel overwhelmed and admit they need help at times.“If you have family or close friends in the area that could provide support, that’s a great place to start,” said Martel.Beyond that, if you haven’t already, Martel suggests reaching out to your employer to see how your job can be adjusted to fit into a new work-life balance.“Maybe it involves little different hours. Maybe it involves a little bit more flexibility,” she said. “I think presenting your boss with that idea, you know just, ‘Hey, I was thinking this might make things a little bit easier. Then I can get done what I need to get done, but also manage my kids and it might take the stress off everyone.’ I think most bosses really right now would welcome that.”Martel also says self-care is not selfish and that it’s important for parents to take moments for themselves during this challenging time.“Doing those things and not feeling bad about it, like ‘Oh, there’s a million things you could be doing right now,’ but maybe you just need to go take a hot bath or you need to just go out and take a walk or do something for you. Do those things,” she said.In the end, Martel says with all the new expectations, working parents should remember to be kind to themselves.“Things are not going to be perfect right now,” she said. “Sometimes just having a decent day with your kid is maybe the most important thing.”Another tip is to see what professional mental health services are available through your employer or covered by your work's insurance.This story was first published by Alex Valverde at WLEX in Lexington, Kentucky. 2082

Less than a month after the Trump administration weakened Obamacare's contraceptive mandate, the University of Notre Dame announced it will stop covering birth control for students, faculty and staff.The Catholic institution, which had long battled the Obama administration over the mandate, will end coverage of contraceptives for employees after Dec. 31. Students, whose insurance follows the academic calendar, will lose the benefits after Aug. 14."The University of Notre Dame honors the moral teachings of the Catholic Church," the University Health Services director wrote to students in an email last week. "To comply with federal law, Aetna Student Health has provided coverage, separate from University coverage, for additional women's health products or procedures that the University objects to based on its religious beliefs."Under Obamacare, insurance plans had to cover contraception for women without charging a co-pay. Over 55 million American women have had access to birth control coverage with zero out-of-pocket costs, according to the National Women's Law Center.Related: Trump administration deals major blow to Obamacare birth control mandateA fairly limited number of employers -- mainly churches and some other religious entities -- could get an exemption to the mandate. Some other employers, such as religious-based universities or hospitals, could seek accommodations so that they didn't have to provide coverage, but their workers could still obtain contraceptives paid for by the insurer or the employer's plan administrator. Notre Dame's students and workers received coverage this way.The Trump administration, however, issued new rules last month that would let a broad range of employers stop offering contraceptive coverage through their health insurance plans if they have a "sincerely held religious or moral objection."Notre Dame is one of the first employers to take advantage of the increased leeway. Its president, Rev. John Jenkins, applauded the administration's decision last month, saying "no one should be forced to choose between living out his or her faith and complying with the law."The university had filed lawsuits seeking relief from the contraceptive mandate in 2012 and then again 2013.The tables have now turned, with the American Civil Liberties Union filing a lawsuit against the Trump administration last month that challenges the new rules. One of its clients, Kate Rochat, is a law student at Notre Dame."While not surprising, Notre Dame's move to block access to affordable contraceptive coverage is deeply disappointing," said ACLU Staff Attorney Brigitte Amiri. "We have already taken legal action against the Trump Administration because our client Kate Rochat and the thousands of other women affected by this decision should not have their access to basic health care services denied simply because of where they work or go to school."Some Notre Dame students are also protesting the university's decision. The Graduate Workers Collective of Notre Dame, an independent group of graduate students, held a rally last month and just started circulating an online petition demanding the administration re-examine the move."The health of people at Notre Dame who can become pregnant, especially those who are low-income, will be jeopardized by obstructed access to reproductive care," the petition reads. "Meanwhile, University representatives are citing religious liberty as the rationale for a policy which is in fact discriminatory. The University's position is philosophically incoherent and morally untenable."Kate Bermingham, who is pursuing her PhD in political science at Notre Dame, said she depends on the free coverage for birth control pills and contraceptive counseling. The graduate student stipend is only ,000 a year, she noted."We shouldn't be materially disadvantaged because we have women's bodies," said Bermingham, 28, who chose Notre Dame because of its strong political theory program. 4016

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