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WELLINGTON, June 7 (Xinhua) -- Scientists in New Zealand have developed a new drug to fight previously untreatable hypoxic cancer tumors, which form in areas of the body starved of oxygen.The researchers at the Auckland University have entered an agreement for the clinical development of CEN-209, which was developed over 10 years of research, said a statement from the university Tuesday.CEN-209 was designed to enhance the effectiveness of radiotherapy and chemotherapy in solid hypoxic tumors, which were resistant to standard cancer therapies, said the statement. In lung cancer patients for example, about half of tumors had hypoxic regions.The new drug worked by damaging the DNA of hypoxic cancer cells, while leaving normal, healthy tissues alone.CEN-209 was designed and created by researchers at the university's Auckland Cancer Society Research Centre (ACSRC), using computer models of drug transport within tumors to accurately predict the anti-tumor activity of the drugs."Our computer models of drug transport developed in-house allowed the synthetic chemists to test their design theories and considerably shortened the discovery process," said Associate Professor Michael Hay, who led the ACSRC research chemists."CEN-209 improves markedly on previous agents in this class in terms of its ability to penetrate tumors, and this is reflected by its improved activity in the laboratory, when combined with long or short courses of radiotherapy," said researcher Professor Bill Wilson.Under the agreement between the university's Auckland UniServices Ltd. and California-based Centella Therapeutics, Inc., a subsidiary of Varian Medical Systems, Inc., Centella will have exclusive rights to CEN-209, which it will develop and trial with Cancer Research UK.The work on CEN-209 is the culmination of a program initiated with funding from the U.S. National Cancer Institute, and more recently from the Maurice Wilkins Centre for Biodiscovery. Ongoing preclinical research on CEN-209 and a backup compound was funded by grants from the Auckland Medical Research Foundation, Genesis Oncology Trust and Health Research Council of New Zealand, said the statement.
HONG KONG, Sept. 9 (Xinhua) -- The Hong Kong Polytechnic University (PolyU) announced Friday that its surveying experts had successfully developed methodologies for precise mapping of the Moon, after intensive analysis of the data captured by the Chinese lunar orbiter ChangE-1 and other lunar exploration missions.According to the PolyU, the team has made significant contributions to lunar mapping. Their efforts culminated in the development of a unique and innovative approach to the creation of accurate 3D models of the lunar surface.The team has produced the most updated parameters of the lunar figure (the shape of the moon), which is essential for lunar mapping using 17.5 million laser altimetry measurements from the ChangE-1and the Japanese SELENE missions.In addition, they also used the new topographic and gravity models to calculate improved crustal thickness and mass distribution of the Moon and established that the average thickness of the Moon's crust is about 40 km on the near side and 50 km on the far side.It was introduced that the resulting lunar mapping was the hard work of a dedicated research team led by Professor Chen Yong-qi, Emeritus Professor of the Department of Land Surveying and Geo-Informatics, who is also serving on the Expert Committee of China's Lunar Exploration Programme (ECCLEP), with the concerted efforts of team members Prof. Chen Wu, Prof. Ding Xiao-li, Prof. Baki Iz, Dr. Bruce King, and Dr. Wu Bo.According to Chen Yong-qi, the lunar mapping project started in 2006. The primary objective was to develop the methodologies and techniques for mapping the Moon surface, which is much more challenging than mapping the Earth's surface because of very few surveyed control points which are essential for accurate map making.Statistics showed that there were only fourteen lunar laser ranging retro reflectors (LRRR) and Apollo lunar surface experiment package (ALSEP) transmitter sites with accurately known coordinates available only on the near side of the Moon, installed by the U.S. Apollo and former Soviet Union Luna missions in the 1960s.Moreover, according to the team, the gravitational field of the Moon is not as well-known as that of Earth, which means the accuracy of the computed lunar satellite's position at any given time is lower than for Earth satellites, thus degrading the mapping accuracy and reliability.In addition, the team expressed that highly reflective lunar surface created significant problems for the automatic processing of images to develop 3D models using the technique of photogramemtry, which is a widely used and highly reliable technique for the creation of maps and 3D models on Earth.Furthermore, the team also revealed they had a plan to compare such data with other data sources in order to evaluate the performance of the ChangE mapping sensors. Since Chen Yong-qi is serving on the ECCLEP, the team has direct access to more recent data captured by the ChangE satellite.

WASHINGTON, June 21 (Xinhua) -- Brain cancer patients who are able to exercise live significantly longer than sedentary patients, U.S. scientists at the Duke Cancer Institute have reported.The finding, published online this week in the Journal of Clinical Oncology, adds to recent research that exercise improves how cancer patients feel during and after treatments, and may also extend their lives.The study enrolled 243 patients with advanced recurrent gliomas, lethal brain malignancies that typically result in a median life expectancy of less than six months. The patients who reported participating in regular, brisk exercise -- the equivalent of an energetic walk five days a week for 30 minutes -- had significantly prolonged survival, living a median 21.84 months versus 13.03 months for the most sedentary patients."This provides some initial evidence that we need to look at the effects of exercise interventions, not only to ease symptoms but also to impact progression and survival," said Lee Jones, associate professor in the Duke Cancer Institute and senior author of the study.
BRUSSELS, May 31 (Xinhua) -- Baby bottles containing the substance Bisphenol A (BPA) would have to be pulled from the shelves across the European Union (EU) starting from Wednesday, in a "milestone" move to better protect the health of EU citizens, an official said Tuesday."Due to the fact that there are uncertainties concerning the effect of the exposure of infants to Bisphenol A, the commission deemed it both necessary and appropriate to take action," said John Dalli, EU Health and Consumer Policy Commissioner."The aim is to further reduce the exposure of the most vulnerable part of our population, i.e. infants," he said.The ban, adopted in an EU directive in late January, would prohibit baby bottles containing BPA from placing on the EU market and import into the 27-member EU from June 1.Previously, the bloc had already banned the manufacture of the controversial baby bottles on March 1, and the industry has been withdrawing such products voluntarily.BPA is an organic molecule that is used in the manufacture of polycarbonate plastics, which are used to manufacture plastic materials, such as baby bottles.Traces of BPA can be released from plastic containers into the food they carry if these containers are heated at high temperatures. They may lead to early sexual development of children and could cause cancer, according to health officials.China would also prohibit the manufacture of feeding bottles containing BPA from June 1, while imports and sales of bottles containing BPA would be banned starting from Sept. 1.
BEIJING, July 15 (Xinhua) -- The Chinese Academy of Agricultural Sciences (CAAS) announced Friday that a group of international scientists has finished sequencing the genetic code of the potato.The Potato Genome Sequencing Consortium (PGSC), which is led by Chinese scientists and made up of 97 researchers from 14 countries, has sequenced the complete potato genome and published a report of its findings in the latest issue of the scientific journal Nature, said the CAAS.The research took six years and revealed that the potato contains about 39,000 genes, said the CAAS.Qu Dongyu, a potato farming specialist with the Crop Science Society of China and a promoter of the PGSC, said the study helped discover genes that define the growth and insect resistance of potatoes.The sequenced genome will enable scientists to create new varieties of potato that are high in yield and quality and more resistant to insects and diseases, he said.Huang Sanwen, a researcher with the CAAS and one of the three corresponding authors of the report, said the sequencing will also allow potato breeders to accelerate the breeding process of new seeds from 10 to 12 years to about 5 years.China is the world's top potato grower, with its farmers planting potatoes on nearly 90 million mu (6 million hectares) of land each year. The average yield per mu stands at 1,000 kg, only one-third of that harvested by countries with advanced technologies, Qu said.
来源:资阳报