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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

ALMATY, Nov. 4 (Xinhua) -- Kazakhstan's Center for Prevention and Control of AIDS said Friday that the country had 17,266 registered HIV carriers as of Oct. 1,compared with 15,908 as of Feb. 1, 2010.Of the HIV-positive people, 1,432 were diagnosed with AIDS while 1,110 people carrying the virus AIDS have died, the center said.Last year, it said, a total of 1,969 new HIV cases were reported in the country.

BEIJING, Nov. 16 (Xinhua) -- A senior Chinese commerce official said on Wednesday that the country will work to optimize the import mix of mechanical and electronic products so they can play a bigger role in China's restructuring efforts.Li Jinzao, vice minister of the Ministry of Commerce, made the remarks at a forum of the ongoing 13th "China Hi-Tech Fair" in Shenzhen.His remarks echoed a guideline issued in March on promoting the imports of mechanical and electronic products during the 2011-2015 period, in which China pledged efforts to encourage the imports of high-tech products.Li said that China will improve existing policies to attach more importance to the imports of advanced technology, equipment and components to spur innovation.Meanwhile, he said China will organize more trading events to exchange and cooperate with international businesses, and will continue to push the United States and European countries to ease restrictions on civil high-tech exports to China.

UNITED NATIONS, Nov. 21 (Xinhua) -- Dramatic progress in science, political leadership, and results indicate that 2011 was a "game changing" year for the international AIDS response, and much progress has been made in 2011 to check AIDS-related deaths since 1997, the peak of the epidemic, a new report released by the Joint United Nations Program on HIV/AIDS (UNAIDS) said on Monday."The Report on the Global AIDS Epidemic 2011" found that new infections were reduced by 21 percent since 1997, and deaths from AIDS-related illnesses decreased by 21 percent since 2005, according to the report.Furthermore, 47 percent (6.6 million) of the estimated 14.2 million people eligible for antiretroviral therapy treatment in low- and middle-income countries were accessing treatment, in increase of 1.35 million people since 2009.The report also found early signs that HIV treatment is having an impact on reducing the number of new HIV infections. As treatment reduces the viral load of a person living HIV to almost undetectable levels, it also reduces the risk of transmitting the virus to an uninfected partner, according to the report. Studies also show that treatment can be up to 96 percent effective in preventing HIV transmission among couples.Eleven countries, including many Sub-Saharan African countries, reached "close to universal access" for AIDS treatment, which is determined to be 80 percent access, in 2011.Botswana made the most dramatic progress in scaling up access to treatment, the report said. While sexual patterns remained relatively stable in the country since 2000, access to treatment increased from less than 5 percent in 2000 to more than 80 percent in 2011.Despite progress, however, the report does note that 2011 marks an unprecedented high the number of people infected with HIV worldwide.Globally, an estimated 34 million people are currently living with the infection. Approximately 2.7 million got infected with the virus in 2010, and as many as 1.8 million people died of AIDS- related illnesses in 2010.Yet the report also notes estimates that as many as 2.5 million deaths are estimated to have been averted in low- and middle- income countries due to increased access to HIV treatment since 1995."Now is not the time to reduce our efforts despite some good news on reducing new infections. Infections are decreasing, but not rapidly enough," said Kim Nichols, executive director of African Services Committee, on Monday at a press conference."There are fewer AIDS deaths, but with the number of infections increasing, prevention has to be the mainstay of our response," Nichols said.Indeed, the UNAIDS report calls for a new framework for investments which are focused on "high-impact, evidence-based, high-value strategies," according to a press release from the UNAIDS website.The framework, which aims to achieve universal access to treatment and prevention centers by 2015, requires a 22-24 billion US dollar funding increase by 2015.Given the withering state of the global economy -- donor funding for the AIDS response has dropped from 7.6 billion in 2009 to 6.9 billion in 2010 -- raising that kind of money may be a long shot. Regardless, UNAIDS'new investment plan calls for smarter uses of less money.According to the report, the framework will focus on high-risk populations like sex workers, men who have sex with men, and people who inject drugs and prevent infections among children, as well as invest in behavior change programs, condom promotion, and treatment, care and support for people living with HIV."The world faces a clear choice: maintain current efforts and make incremental progress, or invest smartly and achieve rapid success in the AIDS response," says the UNAIDS report.

BEIJING, Jan. 21 (Xinhua) -- A locomotive producer in central China's Hunan province on Friday rolled out a low-cost magnetically levitated (maglev) train that is more environmental-friendly than conventional ones.The three-carriage train is designed to run at a maximum speed of 100 km per hour and carry 600 passengers, said Xu Zongxiang, general manager of Zhuzhou Electric Locomotive Co. Ltd. of China South Locomotive and Rolling Stock Corporation (CSR). Xu said the new train was much quieter than conventional ones. While a conventional train moves forward by using friction between its wheels and the railway tracks, the maglev train replaces wheels by electromagnets and levitates on the guideway. According to Xu, his company's has minimized the risk of the new maglev train derailing or overturning. "It's ideal for mass transportation, as it is quiet and environmental-friendly. Its manufacturing cost is about 75 percent of a conventional light-rail train," said Xu. The maglev train has a minimum turning radius of 50 meters and can easily run in residential communities or on hilly slopes. "It's an ideal public transport option for Chinese cities and major tourist destinations," said Xu. Railway transport specialist Liu Youmei, also an academician with Chinese Academy of Engineering, said the new train is green, economical and safe. "It can be used for public transport in populous areas and at scenic spots with fragile environments." Liu said China is one of a few countries that have applied maglev technology. Beijing is building a maglev route, the Daitai line (S1), which starts at its IT center in Haidian district, passes through Shijingshan district, and ends in Mentougou district on its western outskirts. The line will be operational next year.The eastern metropolitan of Shanghai runs the world's first commercial maglev system on a 30-km stretch between the downtown business district and Pudong airport. The German-made maglev went into operation on Dec. 31, 2002.