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SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) -- In an effort to help San Diego's homeless population, the City of San Diego is proposing a third storage facility the homeless can use to store their belongings. The city organized a town hall in July to gather input for the facility that would be placed on 54th and Lea Street.According to the San Diego Housing Commission, the facilities provide a "safe place for individuals who are experiencing homelessness to keep their belongings as they look for work, attend classes, or meet with a service provider or doctor."One of the centers, located on the 200 block of 16th Street, provides bins for more than 400 homeless individuals. Although the centers provide a service to San Diego's homeless population, some residents have made their opposition clear. Before one of the facilities opened in Sherman Heights, residents voiced their concerns. Neighbors told 10News they worried the facility would increase illegal activity and pose safety concerns in the area. To address concerns, security was placed inside the building as well as patrols sent out into the neighborhood. The timeline below shows the recent history of homeless storage centers throughout the city: 1199

SAN DIEGO (KGTV) - It's going to be a great weekend for eating, drinking, and comic book reading in San Diego.The traveling Tequila and Taco Music Festival returns to Embarcadero Park, featuring, you guessed it, tequila, tacos, and great music.For those who won't be attending Comic-Con this summer, San Diego Comic Fest is back with a more casual, intimate approach to all things comic fandom.San Diego's historic Chicano Park will also celebrate Chicano Park Day with a free festival for families in Logan Heights, as well.Here's what's happening in San Diego this weekend:THURSDAYCody JohnsonWhere: House of Blues San Diego; Cost: - Country music star Cody Johnson and his band head to House of Blues Thursday. Mike & the Moonpies will also be in the house for some country music fun. Josh WolfWhere: American Comedy Co.; Cost: (Thursday through Saturday) Comedian, actor, and writer Josh Wolf heads to San Diego with his quick-witted commentary and brutal honesty. 1019

SAN DIEGO (KGTV) — If you're hungry for foodie fun in San Diego, this weekend is an excellent opportunity.Between Taste of Coronado, Ocean Beach Oktoberfest, the annual Polish Festival, and Taste of North Park, hungry San Diegans have their work cut out for them. Each of the events promise delectable tastes of local cuisine with a side of great live music and more.The Halloween season is just beginning and Legoland is leading the charge in Carlsbad with Brick-Or-Treat Party Nights. Guests can take in new live entertainment, costume contests, treat stations, and more across the theme park.SAN DIEGO HALLOWEEN:San Diego's Whaley House: Tour one of America's most haunted homesFrightful fun: San Diego Halloween, fall events for familiesExperience Halloween chills at these San Diego attractionsSpirited shindigs: Halloween parties for San Diego's 21+ crowdFree haunted hikes, Halloween carnivals at San Diego County parksArt is alive and well too. Art San Diego takes over the San Diego Convention Center for a massive showcase and La Jolla pairs art with wine in an annual festival this weekend. Barrio Logan's Bread and Salt also showcases several works from Peruvian artists and galleries.Here's a look at this weekend's events:THURSDAYTaste of CoronadoWhere: Various restaurants; Cost: - Spend the night on Coronado sampling bites from local chefs during the 10th annual Taste of Coronado. Restaurants such as Brigantine, Lobster West, Leroy's, Maretalia, Saiko Sushi, and more will be offering a taste of their cuisine. Legoland Brick-Or-Treat Party NightsWhere: Legoland California; Cost: - 9(Thursday - Sunday) The Halloween season is alive and well at Legoland Park, where kids can enjoy new live entertainment, character meet-and-greets, costume contests, treat stations, and special Lego building activities.FRIDAYOcean Beach OktoberfestWhere: Newport Ave. and Abbott St.; Cost: (Friday - Saturday) OB's unique salute to the annual German celebration Oktoberfest is packed with seasonal fun and brews, including beer stein holding contests, bratwurst eating contests, beers tastings and tons of delicious food, a beer garden, and live music.Art San DiegoWhere: San Diego Convention Center; Cost: Free - (Friday - Sunday) Art San Diego brings artwork from local, national, and international galleries together to view, and also features live entertainment, music, and special programming surrounding beautiful works of art.SATURDAYAnnual Polish FestivalWhere: St. M Kolbe Polish Mission; Cost: (Friday - Sunday) Celebrate Polish heritage in San Diego with delicious Polish cuisine like pierogis and potato pancakes, imported beers, live performances from Polish folk dancers and bands, and vendors in Pacific Beach.FilAmFestWhere: San Diego School of Creative & Performing Arts; Cost: FreeThe Filipino American Arts & Culture Festival celebrates Filipino American History Month with art exhibits, live performances and music, martial arts demonstrations, hands-on workshops, delicious food, and more.Taste of North ParkWhere: Various restaurants; Cost: - Enjoy tastes throughout one of San Diego's most delicious neighborhoods during Taste of North Park. Tickets grant visitors bites from more than 40 North Park restaurants and sips from 15 local brewers.SUNDAYSan Marcos Harvest Festival & Street FairWhere: Via Vera Cruz, between Grand Ave. and San Marcos Blvd.; Cost: FreeJoin thousands of other locals in San Marcos to enjoy the Harvest Festival & Street Fair, packed with more than 200 artisans and vendors, inflatables and carnival rides, live local bands, a wine garden, and delectable tastes from a variety of cooks.La Jolla Art & Wine FestivalWhere: Girard Ave.; Cost: Free(Saturday - Sunday) More than 150 local and international artists will showcase their works in paint, jewelry, woodwork, and more in La Jolla. Guests can also enjoy a wine and beer garden with sips from more than 40 wineries, breweries, and distilleries, live music, and pet adoption opportunities.Latin American Art FairWhere: Bread and Salt, Barrio Logan; Cost: Free(Saturday - Sunday) Enjoy live music and dance performances along with showcases from galleries, collectors, and more than 30 artists, including featured works from Peru. Eats from local chefs, breweries and wineries will also be served. 4351

SAN DIEGO (KGTV) – Interstate 5 near UC San Diego will be closed from Sunday, September 17, through Thursday, September 21, 10:30 p.m. to 5 a.m. each night to accommodate construction of the Gilman Drive Bridge.The new bridge proposes to connect the east and west campus of UC San Diego between Gilman Drive and Medical Center Drive while spanning over Interstate 5.San Diego Association of Governments states: 428