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LOS ANGELES (CNS) - USC researchers have found the likely order in which COVID-19 symptoms first appear: fever, then cough and muscle pain, followed by nausea, and/or vomiting, and diarrhea, it was announced Thursday.Knowing the order of COVID-19's symptoms may help patients seek care promptly or decide sooner than later to self isolate, according to scientists at the USC Michelson Center for Convergent Bioscience. The information also may help doctors rule out other illnesses, or help doctors plan how to treat patients, and perhaps intervene earlier in the disease.The study, which appears in the journal Frontiers in Public Health, was led by doctoral candidate Joseph Larsen and scientists Peter Kuhn and James Hicks at the USC Michelson Center's Convergent Science Institute in Cancer."This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19," said Kuhn, a USC professor of medicine, biomedical engineering, and aerospace and mechanical engineering. "Doctors can determine what steps to take to care for the patient, and they may prevent the patient's condition from worsening."Fever and cough are frequently associated with a variety of respiratory illnesses, including influenza, Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. But the timing and symptoms in the upper and lower gastrointestinal tract set COVID-19 apart."Given that there are now better approaches to treatments for COVID- 19, identifying patients earlier could reduce hospitalization time," Larsen said.To determine COVID symptom chronology, the authors analyzed more than 55,000 confirmed coronavirus cases in China collected from Feb. 16 to Feb. 24 by the World Health Organization. They also studied a dataset of nearly 1,100 cases collected from Dec. 11 through Jan. 29 by the China Medical Treatment Expert Group via the National Health Commission of China.In addition, to compare the order of COVID-19 symptoms to influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998."The order of the symptoms matter, " Larsen said. "Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions." 2440

LOS ANGELES (AP) — Some U.S.-based users of WeChat are suing President Donald Trump in a bid to block an executive order that they say would effectively prohibit U.S. access to the popular Chinese messaging app. The complaint was filed Friday in San Francisco and asks a federal court judge to stop Trump’s order from being enforced. It claims a ban would violate U.S. users’ constitutional rights. Trump has ordered sweeping but vague bans on transactions with the Chinese owners of WeChat and the TikTok app. He says they threaten U.S. national security. The Commerce Department is expected next month to reveal the types of transactions that would be banned. 669

LOS ANGELES (AP) — The number of homeless people counted across Los Angeles County jumped 12% over the past year to nearly 59,000, with more young and old people and families on the streets, officials said Tuesday.The majority of the homeless people were found within the city of Los Angeles, which saw a 16% increase to 36,300, the Los Angeles Homeless Services Authority said while presenting January's annual count to the county Board of Supervisors.The previous tally found a slight decrease in the homeless population.Two years ago, voters passed a tax hike and housing bond to make massive investments to help solve the homeless crisis.Officials said Tuesday the same people have not remained on the streets.The Los Angeles Homeless Services Authority, a county agency, said it helped 21,631 people move into permanent housing during 2018 — a pace that could rapidly end homelessness if economic pressures had not pushed thousands more into the streets.About a quarter of the people became homeless for the first time in the past year, and about half of those cited economic hardship as the primary cause, the authority said.To catch up, cities need to overcome resistance to the placement of housing and shelters, officials said.Supervisor Janice Hahn called the numbers "disheartening.""Even though our data shows we are housing more people than ever, it is hard to be optimistic when that progress is overwhelmed by the number of people falling into homelessness," Hahn said.The Los Angeles County numbers mirror similar point-in-time tallies across California, as state officials struggle to address a lack of affordable housing. In addition, officials said, wages among lower income people have not kept up with the rising cost of living.The count found a 24% increase in homeless youth, defined as people under 25, and a 7% jump in people 62 or older.Officials estimate about 29% of people experiencing homelessness in L.A. County are mentally ill or coping with substance abuse problems.About two-thirds of all people on the streets are male, just under one-third are female, and about 2% identify as transgender or gender non-conforming. 2159

LOS ANGELES, Calif. – "Big Brother" is returning on Aug. 5 with an all-stars season and additional safety protocols for COVID-19.CBS announced Thursday that the reality show hosted by Julie Chen Moonves will return for its 22nd season with a two-hour live move-in premiere event at 9/8c. 295

LOS ANGELES (CNS) - Three men were named Wednesday in a Los Angeles federal grand jury indictment that alleges they distributed narcotics, including counterfeit pharmaceutical pills containing fentanyl, that resulted in the overdose death of hip-hop artist Mac Miller.Cameron James Pettit, 28, of West Hollywood; Stephen Andrew Walter, 46, of Westwood; and Ryan Michael Reavis, 36, a former West Los Angeles resident who relocated to Lake Havasu, Arizona, earlier this year, are charged with conspiring to distribute controlled substances resulting in death and distribution of fentanyl resulting in death.Each of those counts carries a mandatory minimum sentence of 20 years in federal prison and a potential sentence of life without parole, according to the U.S. Attorney's Office.Walter alone is additonally charged with being a felon in possession of ammunition, which, if he were to be convicted, would result in a sentence of up to 10 years in federal prison.Court documents allege the three defendants distributed narcotics to 26-year-old Malcolm James McCormick -- who recorded and performed under the name Mac Miller -- two days before the entertainer suffered a fatal drug overdose in Studio City on Sept. 7, 2018.The Los Angeles County Medical Examiner-Coroner later determined that Miller died of mixed drug toxicity involving fentanyl, cocaine and alcohol.According to the indictment, late on the night of Sept. 4, Pettit agreed to supply the rapper with 10 ``blues'' -- a street term for oxycodone pills -- as well as cocaine and the sedative Xanax. But instead of providing Miller with genuine oxycodone when he made the delivery during the early morning hours of Sept. 5, Pettit provided counterfeit oxycodone pills that contained fentanyl -- a powerful synthetic opioid that is 50 times more potent than heroin, according to the indictment.The indictment alleges that Pettit ordered the fentanyl-laced pills from Walter, and then Reavis delivered the narcotics to Pettit. Investigators believe that Miller died after snorting the counterfeit oxycodone pills containing fentanyl allegedly provided by Pettit. While another individual supplied Miller with other drugs prior to his death, those narcotics did not contain fentanyl, prosecutors said.Less than one month after Miller's death, Walter agreed to sell Pettit another 10 blues, according to the indictment, which also alleges other drug deals between the two men, with one as recent as Aug. 30. The indictment further alleges that Reavis was involved in drug trafficking activities in June and quotes a text message he sent after realizing he was negotiating a narcotics transaction with an unknown person that reads, in part: ``People have been dying from fake blues left and right, you better believe law enforcement is using informants and undercover to buy them on the street ... they can start putting (people) in prison for life for selling fake pills.''U.S. Attorney Nick Hanna said it has become ``increasingly common for us to see drug dealers peddling counterfeit pharmaceuticals made with fentanyl. As a consequence, fentanyl is now the number one cause of overdose deaths in the United States.''Hanna alleged that the three defendants continued to sell narcotics after Miller's death, ``with full knowledge of the risks their products posed to human life.''Special Agent in Charge William D. Bodner of the Drug Enforcement Administration's Los Angeles Field Division warned that counterfeit pharmaceutical pills are especially dangerous because users are unable to verify what they are ingesting.``The tragic death of Mac Miller is a high-profile example of the tragedy that is occurring on the streets of America every day,'' Bodner said, adding that the indictment ``highlights the efforts of DEA agents, local law enforcement officers, and prosecutors who work tirelessly to bring dangerous drug dealers to justice.''Pettit, who was previously ordered detained after being charged in a criminal complaint with distributing narcotics to McCormick, is scheduled to be arraigned in downtown Los Angeles on the indictment on Oct. 10.Walter was arrested on Sept. 23 on a criminal complaint alleging conspiracy to distribution narcotics, and he was also ordered held without bond. Walter also is scheduled to be arraigned on the indictment Oct. 10.Reavis, who was taken into federal custody in Arizona on Sept. 26 on charges of being a felon in possession of a firearm, is currently in custody and is being transported to Los Angeles by the U.S. Marshals Service. 4553