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The Thomas Fire, the largest fire in California's modern history, ignited in December and burned about 281,900 acres in Ventura and Santa Barbara counties.Santa Barbara County officials have issued a mandatory evacuation order affecting about 30,000 people in extreme and high-risk debris flow areas ahead of the strongest storm of the season in that region. The mandatory evacuation there was effective from noon Tuesday for burn areas near the Thomas, Sherpa and Whittier fires.The amount of rain and the intensity are enough to cause flooding even without the impact of the recent fires."We could experience localized flooding and road closures, which are not isolated to the burn areas. The threat of rock falls, mudslides and debris flow is high," said Rob Lewin, director of the Santa Barbara County Office of Emergency Management.Mandatory and voluntary evacuations also took effect at noon Tuesday in Ventura County.Los Angeles County officials ordered evacuations in areas affected by the recent Creek and La Tuna Canyon fires starting at 6 p.m. Wednesday, and warned other residents living in areas affected by recent fires to prepare for evacuations and street closures.The large and powerful storm system across the eastern Pacific Ocean is expected to bring periods of moderate to heavy rain through late Thursday or early Friday.Atmospheric rivers are long, narrow channels that transport water vapors outside the tropics. The one that's saturating California is known as the Pineapple Express,?because it brings moisture from the tropical Pacific near Hawaii and can wallop the West Coast with rain and snow.The National Weather Service predicts rainfall rates between a half to three-quarters of an inch per hour, with rain totals of 5 to 10 inches in the foothills and mountains. This total is significantly more than during the January 9 debris flow, when there were 3 to 6 inches of rainfall across the region. 1954
The researchers analyzed 139 bacterial samples from two Melbourne hospitals collected over 19 years ending in 2015. They studied how well each sample survived when exposed to diluted isopropyl alcohol.The isolates gathered after 2009 were, on average, more tolerant to the alcohol compared with bacteria taken from before 2004, the researchers discovered. Conducting mice experiments and further analysis, they also saw that alcohol-tolerant bacterial samples harbored several genetic mutations involved in metabolism, which made them better equipped to live in the gut.Although the results suggest that microbes can adapt to alcohols and other ingredients found in disinfectants, this conclusion cannot be drawn until more research is done, the researchers warn."There are two things we are working on," said Tim Stinear, a co-author of the study and professor at the University of Melbourne. "One is understanding exactly how the bacteria are becoming more tolerant. ... The second is what's going on in other parts of the world, and we are working with colleagues around the world to address that."One-third of all enterococcal infections in Australian hospitals are caused by E. faecium, according to Stinear and his co-authors. Of these, 90% were ampicillin-resistant strains, and half of those were resistant to vancomycin, another common antibiotic. Even when doctors try a higher-grade antibiotic to treat such illnesses, the outcome may be further drug resistance -- and a longer-lasting infection for the patient.Study co-author Paul Johnson, an infectious diseases professor and director of research at Austin Health in Melbourne, said that when it comes to preventing certain outbreaks, including vancomycin-resistant enterococci, hospitals might need to use more than standard precautions such as hand hygiene."We might need to specifically add additional control measures," he said. Such measures could include using an additional bacteria-killing agent, such as chlorhexidine, to sanitize hands in some medical care settings.True perhaps in hospitals, but the same might not apply to the world at large. 2118

The Russian government has set up a commission into the sinking of the dock, investigating both the cause of the accident and whether the structure should be lifted back to the surface.Russian state media said the operation to refloat the dock would be "tricky" and is likely to take at least six months. 309
The U.S. Forest Service said the Holy Fire has forced the evacuation of nearly 7,500 homes and structures. At least 12 structures have been destroyed. The estimated number of people evacuated is 21,484 as of Friday morning. 223
The teachers then watched a guided talk, where recruits debriefed on important topics, like what it means to be thanked for your service.You're not thanked for what you've done for your country, a platoon leader said, you're thanked for the generations before you who have kept our country free.The teachers were in awe the recruits were eager to respond when a question was asked.Around noon the educators met up with recruits set to graduate that Friday."I always thought it was just all grunts, like that's all you had. I've learned that you can have specialized jobs," Woodward said, surprised there are positions in the band or manning artillery."It actually is a great opportunity, it's fun, they all enjoy it, you know the schooling is great, the benefits are great, the retirement's great," Perkins said.Recruit Joshua English said he's always dreamt of being in the Marines. He has veterans in the family and was chosen the first day of training for a leadership role, known as the "guide". 1004
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