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TORONTO, Canada (KGTV) - Incredible dash cam video shows tires flying after a car hit a tow truck Saturday on a Toronto, Canada highway.The camera attached to Adil Kanan’s tow truck was recording the moments Kanan stepped out to help three people in a disabled pickup truck."They seemed to be all alert and fine," he told CTV Toronto.RELATED: Tow truck driver seriously injured in crash on SR-125Karan returned to his truck to alert police that his vehicle and a truck were blocking one lane of the freeway."As I was sitting there looking through my back window, that's when I observed the white Lexus approaching at a high rate of speed," he said.The white vehicle hit the pickup truck, sending debris flying.RELATED: Bear opens door, steals from car in Lake TahoeOne of the pickup truck’s passengers had been standing outside the truck and was thrown into the guardrail.Two people inside the truck were ejected, and the driver ended up face-down on the highway. All three were listed in stable condition.CTV News contributed to this report.  1056

Top North Korean officials warned the United States in a letter that denuclearization talks are "again at stake and may fall apart," sources familiar with the process told CNN.The letter was delivered to US Secretary of State Mike Pompeo, who abruptly canceled his fourth trip to Pyongyang, hours before he was scheduled to depart with his new special envoy Stephen Biegun on Friday, sources said.Three sources with direct knowledge of the North Korean position on denuclearization said the letter stated that Kim's regime felt that the process couldn't move forward because "the US is still not ready to meet (North Korean) expectations in terms of taking a step forward to sign a peace treaty."The US has so far been unwilling to replace the armistice agreement that ended the Korean War with a permanent, legally binding peace treaty, which would require the approval of two-thirds of the US Senate.If a compromise cannot be reached and nascent talks crumble, Pyongyang could resume "nuclear and missile activities," the sources said.The existence of the letter, sent to Pompeo by Kim Yong Chol, the former head of North Korea's spy agency, was first reported by the Washington Post.The Post, which characterized the letter as a "secret" communication, said it wasn't clear how Kim had gotten the letter to Pompeo, but suggested that it may have been sent through its UN mission.However, Pompeo has been relying on other backchannels, as opposed to dealing directly with his diplomatic counterpart North Korean Foreign Minister Ri Yong Ho, one source said."Before and after Pompeo became the Secretary of State, he seemed to be more interested in maintaining and engaging with Kim Yong Chol through a backdoor channel, rather than with his formal counterpart Ri Yong Ho," said the source. 1809

Today @probsolvecaucus unveiled the “March to Common Ground” COVID Stimulus Framework to help get negotiators back to the table and get resources to American families and small businesses. https://t.co/eJxHNPwITv— Problem Solvers Caucus (@ProbSolveCaucus) September 15, 2020 282

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

There is nothing like the sound of a baby's cry and for a new mom like Whitney Eberhardt, it can be daunting.“When you first come home from the hospital you have no idea what you are doing and when they are crying you sometimes have no idea why. So, it’s nice to have something to help you out,” said Eberhardt.On average, doctors say a newborn can cry a total of 2 hours a day, and that’s why Dr. Ariana Anderson of UCLA created the app, Chatter Baby.“I thought it would be good to make a device that would help new parents and possibly deaf parents. So, when they were around their baby crying and said, why is my baby crying they would have some sort of answer,” said Dr. Anderson.Chatter Baby is in its infancy stage and currently only gives three reasons for your baby crying. The three reasons are when a baby's in pain, fussy or hungry.Eberhardt tried out the app and said it is easy to use. You press record for five seconds as your baby is crying and the app will then compare the cry to the sounds in a database to determine a reason. The Chatter Baby database of cries was created with the help of new parents.“We think the best judges of the baby are parents themselves. We had the parent initially label the cry. So a mother would say, my baby is hungry, so if two other mothers agreed with that description of the babies cry then we would include that cry in our data base,” said Dr. Anderson.Certain cries have a different acoustic sound. For example, babies who are in pain might have a cry with high energy or a fussy cry may have more periods of silence.“Once we had an agreement amongst the mothers we trained artificial intelligence algorithms to look for patterns in the cry that were specific to hunger to pain to fussiness,” said Dr. Anderson.With the help of artificial intelligence, Chatter Baby’s algorithm claims 90% accuracy whether your baby is crying or not and correctly flags more than 90% of pain cries.However, as you get more comfortable knowing why your baby is crying, you can tweak the app yourself to make it more accurate.“We want to have a way for parents to revise, update and improve the algorithym.so the algorithm gets returned to their specific baby,” said Dr. Anderson.Eberhardt said the app is a great safety net for all new parents.  2315