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The U.S. reported yet another daily high mark for newly reported cases of COVID-19 on Thursday with nearly 188,000, according to a database kept by Johns Hopkins University.The U.S. reported at least 187,833 positive COVID-19 tests on Thursday, breaking the all-time record of 177,224 that was set six days prior, on Nov. 13.Thursday marked the eighth time in November that the U.S. broke the daily record for newly reported cases as the COVID-19 continues to spread across the country. About 2.5 million people in the U.S. have contracted the virus since the start of November.The spike in cases has led to all-time highs in hospitalizations linked to the virus. The COVID Tracking Project reports that more than 80,000 people are currently hospitalized with the virus across the country — an all-time record that surpasses even the early portions of the pandemic. According to the COVID Tracking Project, 71% of those hospitalizations occur in the Midwest and South, leading to many rural hospitals running short on resources. Some states like South Dakota and Iowa say their hospitals are at their breaking points.Thursday also saw reports of 2,000 deaths linked to the virus — the first time the U.S. has seen that many reported deaths in a single day since May 6. Since Oct. 17, daily deaths linked to COVID-19 on a seven-day rolling average have nearly doubled from about 700 a day to more than 1,300 a day. The continued spike comes amid a rash of promising news in the hope for a COVID-19 vaccine. On Friday, Pfizer announced that it had filed for Emergency Use Authorization for its vaccine candidate, two days after initial studies showed it to be 95% effective in large-scale trials. Several other drugmakers have also reported that their vaccines are on the precipice of authorization.However, health experts warn that the U.S. is in for a rough few months. Vaccines will initially need to be rationed for people in high-risk populations and health care workers. Dr. Anthony Fauci has said he believes vaccines won't be widely available until April. 2075

The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The University Hospitals Fertility Clinic in Cleveland is facing dozens of legal actions after the failure in early March of a cryopreservation tank containing approximately 4,000 eggs and embryos belonging to at least 950 families."We currently represent well over 100 clients whose cases we will pursue as individual claims. That number is growing by the day," Cleveland attorney Tom Merriman said Monday.Also Monday, attorney Gloria Allred threw her hat into the ring, announcing litigation on behalf of three Pittsburgh women who are all cancer survivors. 567

The sudden and abrupt breakdown of the US Postal Service has unfolded in recent days as Democrats call for a funding boost ahead of this year’s presidential election.On Friday, the USPS announced a temporary price increase in some services from Oct. 18 until Dec. 27. The rate hike affects commercial services, as retail services are not affected.Meanwhile, the USPS has been removing mailboxes and processing machines. The machines and mailboxes are being removed across the country, according to local reports from a number of Scripps stations.On Friday, CNN and the Washington Post reported that a number of states have received letters from the Postal Service warning that they might not have the ability to ensure ballots are sent and returned in a timely manner. The warning comes as more Americans are expected to utilize mail-in voting due to the coronavirus pandemic.“The Postal Service is asking election officials and voters to realistically consider how the mail works,” Martha Johnson, a spokeswoman for the USPS, said in a statement to the Washington Post.Despite requesting a mail-in ballot himself for next week’s Florida primary, President Donald Trump has tried to sow doubt in recent weeks over the reliability of mail-in voting, claiming that the process is ripe with fraud. But there has been limited evidence to suggest his fears are founded.With the postal service facing financial troubles due to rising pension costs and decreasing usage, Trump said he would agree to funding the Postal Service, but would need some concessions from Democrats."Sure, if they gave us what we want. And it’s not what I want, it’s what the American people want," Trump said Friday. 1694

The two women from Hawaii who say they were lost at sea had an emergency beacon on the ship that was not activated during their roughly five months at sea, a Coast Guard spokeswoman tells CNN.The mariners, Jennifer Appel and Tasha Fuiava, had one EPIRB (Emergency Position Indicating Radio Beacon) on board, which was properly registered," Coast Guard Petty Officer 2nd Class Tara Molle told CNN.The emergency beacon, which is found on many vessels, is used to alert rescue locations around the world in the event of an emergency, "by transmitting a coded message on the 406 MHz distress frequency via satellite and earth stations to the nearest rescue coordination center," according to EPIRB.com. 706