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Today would be a normal drive to work for Amelia Caceres — except her house is surrounded by police tape. Adrian Perez helped her get out, both still in shock after hearing the brand new bridge outside their home collapsed."We were some of the first people on the front,” Caceres said. “And we saw the cars crushed underneath it was really horrifying, so it was really scary.”“My mind just does not captivate that that happened,” Perez said.Caceres and Perez saw the scene unfold, in disbelief. “It’s kind of like surreal,” Perez said. “Like it was a movie. There was a woman — I guess that she was trapped in the car like under the car .. she was crying hysterically. It was just really strange.”What made it even more strange for these two is that they had just watched the bridge go up days before.“It was just up. It was done,” Caceras said. “And it seemed almost like it was amazing that they had done it so quickly.”The bridge was designed to provide a safe way for students at Florida International University, like Perez, to cross a busy highway."I was really excited about this bridge because I was like finally I won’t have to go through the death trap that is eighth street crossing," Perez said. "Now, that’s kind of ironic."Carlos Devarona lives less than a mile away, and travels the street every day.“You have a blind faith in construction,” Devarona said. “You never think something like this is going to happen.”Watching the scene left him with even more questions, specifically why officials chose to perform a stress test in the moments before the collapse. “Not above live traffic  — you don’t do that,” Devarona said. “It just should never happen.”As investigators work to answer the many questions surrounding the collapse, Perez and Caceras, like so many others, wait for answers.“I’m sure that they did what was needed to get done,” Perez said. “I don’t think anyone would do something like this purposefully. Or negligently. I guess we will see.” 2034

There is no question the coronavirus pandemic is changing how Americans shop, with an increase in delivery, drive thru and curbside pick-up.Later this year, fans of Wawa will be able to get their favorite convenience store items in a drive thru. The east coast-based company announced they are building a freestanding drive-thru at an intersection in Lower Bucks County Pennsylvania. They are also adding drive-thru features to a Wawa under construction in Westhampton, New Jersey.In a press release, Wawa says the standalone store, not attached to a gas station, will feature “state-of-the-art technology to quickly order Wawa’s most popular food and beverages, including value meals, combo meals along with coffee and specialty beverages.” If the drive-thru line gets too long, customers will be able to pull into curbside parking and wait for their order.Construction will start this month, with an opening planned for December.“We are hoping to learn from the layout, workflow and traffic flow at this location, as we continue to explore alternatives for longer term application to our stores post-COVID-19,” said Terri Micklin, Director of Construction, Wawa. 1172

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

THOREAU, N.M. (AP) — New Mexico authorities say multiple people have been killed in a commercial passenger bus crash along Interstate 40.New Mexico State Police did not say how many people died or how many were injured in Thursday's crash.They said passengers were transported to a hospital and a phone number was set up for family members seeking more information about people who were aboard the bus.The wreckage included a Greyhound bus with front-end damage and a semi-truck that was on its side and with its cargo strewn across the highway and the median.Greyhound says the bus was heading from Albuquerque to Phoenix and there were 47 passengers on board.Spokeswoman Crystal Booker says it's unclear what caused the crash.The crash forced the closure of the westbound lanes of the interstate and traffic was backing up as travelers were being diverted. 866

This year's National Voter Registration Day was the largest in history, in part, because businesses assisted people to register or update their information. Many businesses say it's their duty to help people vote.Tanger Outlets in cities such as Daytona Beach, Florida, San Marcos, Texas and Savannah, Georgia, held registration events for shoppers coinciding with National Voter Registration Day. This year, records were smashed on National Voter Registration Day as 1.5 million voters registered, and hundreds of those were through the Tanger Outlet event.“It spoke to the traffic that the center saw that particular day, but we’re going to make this an annual event because of the returns they got,” says Stephen Yalof, president and chief operating officer of Tanger Outlets.“We’re very youth oriented, youth conscious in that we feel like the younger people in America have a voice and we want to make sure that we get a hold of them and make sure that they register and have a chance to have their voices heard when it comes to voting,” says Yalof.Tanger is just one of the many businesses that felt the need to get involved.“We’re very clear; we’re an ice cream company but we believe with adding a little bit of sweetness to assist the groups who are working on the front line who work to bring systemic change in the world,” said Jabari Paul, U.S. activism manager for Ben & Jerry'sBen & Jerry's, he says, does so much more than make and sell ice cream.“People can walk into our shops and there’s usually information somewhere up in the shop that informs you of the issues we care about, the issues our partners are working on," Paul said.These days, Paul says, that issue surrounds voting. Their "Scoop Shops" around the country are also called "action stations." Part of the campaign involves sending a text to easily check your registration status.“We believe businesses have a role to play in helping create a better society and that role can go far beyond corporate giving, and businesses have a huge platform they can lend in terms of uplifting very important issues,” says Paul.“You’ve seen so many people this year step it up, and I think you know, we’ve had some good corporate partners and efforts simply because people want to do their part and it's needed,” Ben Hovland, chairman of the U.S. Election Assistance Commission, said.The bipartisan, independent group focuses on elections and how they're run around the country. In the early days of the pandemic, there were serious drops in registration because places where people register, like the DMV, were closed. So, Hovland says, the help from businesses is critical.“This year you saw a lot of - a real outpouring of community participation, both government officials, the EAC is a partner in that effort,” Hovland said. “Civic groups, also corporations, celebrities, sports teams just promoting this idea of voter registration and for people to get registered.”Depending on where you live, you may still be able to register or update your registration, which is critical to being able to make sure your vote counts. 3107

来源：资阳报