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Tom Steyer is spending another million to put a second anti-Donald-Trump advertisement on national television -- this time taking aim at the President's tax overhaul push.The ad comes less than a month after the Democratic mega-donor and billionaire environmentalist spent million on a one-minute ad calling for Trump's impeachment.The second installment of Steyer's anti-Trump ad campaign begins Thursday with a spot filmed on Steyer's ranch in Pescadero, California. 484
This is what's happening in the world of politics Saturday, Aug. 25, 2018.Trump fires back at Sessions— President Donald Trump fired back at U.S. Attorney General Jeff Sessions, saying the AG doesn't understand what's happening at the Department of Justice. "Jeff Sessions said he wouldn't allow politics to influence him only because he doesn't understand what is happening underneath his command position," Trump tweeted. "Highly conflicted Bob Mueller and his gang of 17 Angry Dems are having a field day as real corruption goes untouched. No Collusion!"After previous criticisms this week by the president, Sessions said, "While I am Attorney General, the actions of the Department of Justice will not be improperly influenced by political considerations."Read more. Juror: Pardoning Manafort would "be grave mistake"— A juror who sat on the Paul Manafort trial said to would be a "grave mistake" if a presidential pardon came for the former Trump campaign manager."I feel it would be grave mistake for President Trump to pardon Paul Manafort," Paula Duncan, one of the jurors, said during an interview with Anderson Cooper. "Justice was done, the evidence was there and that's where it should stop."Duncan was one of the 11 jurors who convicted Manafort on five tax fraud charges, one charge of hiding foreign bank accounts and two counts of bank fraud. The jury was hung 11-1 on the other 10.Manafort faces 80 years in prison.Read more. Pompeo's meeting with North Korea canceled— President Trump has asked Secretary of State Mike Pompeo not to go to North Korea, citing insufficient progress of denuclearization and China's reluctance to help further due to trade tariffs."I have asked Secretary of State Mike Pompeo not to go to North Korea, at this time, because I feel we are not making sufficient progress with respect to the denuclearization of the Korean Peninsula. Additionally, because of our much tougher Trading stance with China, I do not believe they are helping with the process of denuclearization as they once were," Trump wrote on Twitter.Pompeo had announced he would be in Pyongyang with his new Special Representative for North Korea Stephen Biegun.It would have been Pompeo's fourth trip to the country following Trump's Singapore summit with Kim Jong Un.Read more. 2365

Travis Reinking, the man accused of killing four people at a Nashville-area Waffle House on Sunday, is now in custody, Metro Nashville police said Monday. The arrest in a wooded area behind an apartment complex capped a day-long manhunt for the suspect police say unloaded an assault-style rifle at the restaurant in Antioch early Sunday morning.The tragedy sparked a cycle of shock, grief and anxiety among residents throughout Nashville.Nashville public schools started "lock-out" procedures Monday while Reinking was on the loose. Police warned residents to keep their doors locked.It's not clear what Reinking did during his roughly 35 hours on the run. 665
Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676
They have traveled for days on foot and by bus. They are tired, hungry and desperate for a better life.President Donald Trump described the Central American migrants traveling in a caravan through Mexico as dangerous but many of them are women and children.As many of them stay south of the border to find work there and some 200 or so migrants continue their journey into the US, here's a look at some of their stories: 428
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