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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959
LOS ANGELES (CNS) - A bout of overnight rain will have the potential to unleash rockslides, mudslides and minor debris flows in areas recently stricken by wildfires, National Weather Service forecasters said.The NWS said there's a chance of rain Wednesday evening, a virtual certainty of it after midnight amid southwest winds of around 15 miles per hour and a 50 percent chance on Thanksgiving morning, followed by a partly cloudy afternoon.Between seven-tenths of an inch and an inch-and-a-quarter of rain are expected to fall on coastal slopes and in the foothills, which could trigger slides over areas denuded by the Woolsey Fire in L.A. and Ventura counties and the Hill fire in Ventura County, forecasters said. Highway 1 and Santa Monica Mountain canyon roads are particularly vulnerable, they said.Authorities reminded Southlanders in burn areas of flood safety preparations that should be made before the rain starts.RELATED: Light rain falling in Northern California could hurt Camp Fire search effortThe Woolsey Fire unified command warned that mud and debris flows ``are a very realistic threat to the communities affected by the Hill and Woolsey fires. Due to an increased probability of mud and debris flows in these fire areas, it is important to plan and prepare. Evacuation orders should not be taken lightly, and are ordered because there is a threat to life and property.''Some fire-damaged areas remain unsafe, the electrical system is ``extremely damaged,'' and road crews are working to clear rocks as emergencypersonnel prepare for the impending storm, Department of Public Works Director Mark Pestrella told the Los Angeles County Board of Supervisors.``We're going to have rock fall, we're going to have roads closed,'' Pestrella said. ``The roads will not be safe to travel beginning Wednesday evening."Pestrella said he expected Pacific Coast Highway would be closed at some point.Up-to-date information on road closures can be found at www.lacounty.gov/woolseyfire/rain-after-fire-resources.The NWS said there is a 30 percent probability that the upcoming rainfall will be sufficient to trigger debris flows in the Woolsey Fire and Hill Fire areas.Burn area residents concerned about mudflow can pick up empty sandbags at their local fire stations, and can visit www.lacounty.gov/larain for storm season emergency resources, including Los Angeles County's ``Homeowners Guide to Flood, Debris and Erosion Control.'' The sandbags should be used to divert potential flows, not dam them. 2520
LOS ANGELES (AP) — Ariana Grande has announced she is engaged in a series of social media photos of her and her fiance, and her engagement ring. The “Rain on Me” singer posted the photos of her cuddling with Dalton Gomez, a luxury real estate agent, on Sunday. The post reads "forever n then some (sic)" and includes a close-up photo of the pearl and diamond engagement ring. 384
LOS ANGELES (CNS) - Achieving a feat that a human being might even find difficult, a mountain lion successfully managed to cross the San Diego (405) Freeway in the Sepulveda Pass, National Park Service officials announced Thursday. Researchers believe the lion known as P-61 managed to traverse the freeway from west to east between 2 and 4 a.m. July 19. According to the NPS, another lion named P-18 was fatally struck by a vehicle in the same area of freeway while attempting a crossing in 2011, and another lion that was not being tracked by researchers was struck and killed in 2009. The only other lion known to have crossed the 405 Freeway is Griffith Park's famed resident lion P-22. That lion was not being tracked with a GPS collar at the time, so little is known about where and when he made the trek. Researchers say DNA testing shows P-22 was born in the Santa Monica Mountains, so he must have crossed both the 405 and 101 Freeways to have reached Griffith Park. ``Although P-61 successfully crossed the 405, his feat is a reminder of how challenging Southern California's road network is for mountain lions and other wildlife as well,'' said Jeff Sikich, a biologist with the Santa Monica Mountains National Recreation Area. ``Others haven't been so lucky.'' The issue of extensive development and freeways acting as physical barriers to migration have long been identified as threats to the continued survival of mountain lions in the area. At least one study has suggested that the lions will be extinct within 50 years due to the lack of breeding partners, leading to rampant inbreeding among the current population. P-61 now inhabits an area between the 405 and 101 Freeways, where researchers say at least one other lion resides. That lion is not outfitted with a GPS collar and has only been seen on surveillance footage in the area over the past five years. ``It will be interesting to see if P-61 stays in the area, whether he decides to challenge the uncollared lion or if he heads back to the other side of the freeway,'' Sikich said. ``Although it's a relatively small area of habitat, it's certainly larger than the Griffith Park area and does have a patchwork of natural areas.'' P-61 is believed to be about 4 years old. The lion was first captured and fitted with a GPS collar in October 2017. 2330
LOS ANGELES (AP) — Republican Young Kim has defeated Democratic U.S. Rep. Gil Cisneros in Southern California. The contest was a rematch from 2018, when Cisneros delivered an upset in what had been a longstanding GOP district anchored in Orange County. Kim’s victory Friday in the 39th Congressional District overcame President Donald Trump’s poor performance in heavily Democratic California, where he got only one-third of the votes. The former state lawmaker was born in South Korea and grew up in Guam. Another California Republican born in South Korea — Michelle Steel — defeated Democratic U.S. Rep. Harley Rouda in another Orange County district. 661