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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527
COSTA MESA, Calif. (AP) — A judge has put on hold a U.S. plan to quarantine up to 50 people infected with a new virus from China in a Southern California city. Costa Mesa officials asked for a court to intervene Friday after learning that federal authorities planned to move patients to facility in the city as early as Sunday. They said they were not included in the planning effort and wanted to know how the local community would be protected from the possible spread of the virus that has spread globally. The judge has issued a temporary restraining order and has scheduled a hearing for Monday. 609

COVID-19 has killed more than 50,000 people in nursing homes and long-term care facilities. That is at least 40% of all U.S. coronavirus deaths.The White House put in new measures recently to better protect residents.“The numbers are continuing to rise. We're just beginning to get some of the numbers out of some of the states and so this is a real outrage,” said Bill Sweeney, Senior Vice President of Government Affairs at AARP. “It didn't have to be this way, and this is a national disgrace.”AARP says required virus case data from facilities is happening too late. They're about a week behind and testing isn't consistent.Some facilities are still having issues with PPE, including training staff to wear it properly.Both Republicans and Democrats want to give more help to nursing homes in the next relief bill.AARP is concerned about the lack of inspections and oversight. It worries some facilities will get immunity from lawsuits.“Without inspections, without the ombudsman being able to go in and find out what’s going on in the facilities, without family visits being allowed, there's been no accountability at all and if they give immunity to these nursing homes, there won’t ever be accountability,” said Sweeney. “There will never be justice for families whose loved ones were treated poorly.”Before the pandemic, AARP says eight out of ten nursing homes were cited for infection control problems.Meanwhile, AARP encourages family members to call their representative in Congress if they are worried about their loved one and are not getting answers. 1573
Conditions at the border are getting worse as desperate migrants wait for asylum. Many have given up hope in their desperate hour. The shelter where migrants are staying is packed to the brim. It’s said to be completely full and actually three times above capacity. Conditions are getting worse as officials with the state’s special committee on migration issues say city and state officials are even looking for a second shelter, but no local businesses are willing to rent out their facilities for the migrants. People at the shelter have reported deteriorating conditions including open sewage drains. The Mexican Navy has set up small kitchens and the Red Cross is providing medical care. Migrants say they want the U.S. to speed up the political asylum process, saying it’s taking too long. 804
Community Advisory:I have been informed of an unoccupied vehicle that fell into a large sinkhole in #Maspeth. (1/3) pic.twitter.com/befhoLtlvY— Robert Holden (@BobHoldenNYC) November 26, 2020 199
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