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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.
BEIJING, Nov. 22 (Xinhuanet) -- Underweight patients may have more possibilities of mortality within 30 days of general and vascular surgery compared with mildly obese patients, according to a research published online in Archives of Surgery Tuesday.Researchers at the U.S. National Surgical Quality Improvement Program conducted the research for the years 2005 and 2006, and assessed the contribution of BMI (Body Mass Index) to 189,533 postsurgeries morbidity and mortality by obesity classes.They found that compared with the middle BMI quintile group, patients with BMI value below 23.1, had greater chances for death. For the highest BMI quintile group, higher mortality rate was also observed.However, the researchers also found that obesity may as well be associated with increased mortality for some individual types of surgeries."These individual types of procedures include procedures with which the general surgeon should have definite experience: colorectal resection, colostomy formation, cholecystectomy, hernia repair, mastectomy, and wound debridement," said George J. Stukenborg, PhD, of the University of Virginia inCharlottesvilleand his colleagues.Based on a 30 –day morbidity and mortality risk calculation, the sample patients were categorized into BMI quintile ranges. BMI value of less than 23.1 was considered as lowest, values from 26.3 to 29.6 considered as the middle quintile, and above 35.2 considered as the highest.Factors such as lack of enough data on nonfatal complications and hospital resources, or examining mortality over the 30-day baseline, may cause limitations and inaccuracy to the research and more studies on a wider range of patients in terms of BMI are needed to further confirm the current conclusion, researchers said.

BEIJING, Nov. 25 (Xinhua) -- The BRICS members should make joint efforts to help ease tension in the Middle East and support the region's countries in carrying out political transition and social reconstruction on their own, Chinese Foreign Ministry spokesman Liu Weimin said Friday.Liu made the remarks at a daily press briefing, after Vice Foreign Minister Zhai Jun attended a deputy foreign ministers' conference of the BRICS in the Russian capital of Moscow on Thursday.The BRICS countries' enhanced communication and coordination, joint maintenance of the basic principles of international law, and opposition to foreign armed interference in the region are in line with the common interests of Middle East countries and the international community, Liu said."China will make concerted efforts with the international society, including BRICS members, to make constructive contribution to the Middle East's peace, stability and development," Liu said.The spokesman quoted Zhai Jun as saying at the Moscow conference that the Middle East's situation has a significant impact on international politics, economy and security in addition to the impact on the political and social situations in the region.It conforms with the common interests of the region's countries and the international community for the Middle East to be politically open and inclusive, independent in foreign policy, sustainable in economic development, and peaceful and stable in security matters, Zhai was quoted as saying.Liu Weimin said a joint communique was issued at the Moscow conference. The communique called on various parties to respect the state sovereignty and territorial integrity of the Middle East countries, have extensive dialogues by peaceful means, and make active efforts to seek solutions to the crisis.The BRICS members oppose the interference in the Middle East countries' internal affairs by foreign forces, advocate the positive role of the United Nations Security Council, and urge various parties to strictly observe the authorization of the UN Security Council, according to Liu.BRICS is an acronym for Brazil, Russia, India, China and South Africa.
HANOI, Oct. 25 (Xinhua) -- The hand-foot-mouth disease (HFMD) and dengue were on the rise across Vietnam, reported the Vietnam Preventive Medicine Administration (PMA) on Tuesday.As of Oct. 23, the country had more than 76,120 HFMD patients and 135 fatalities. The number of incidents has increased significantly over the last few weeks, with an average of 2,000-2, 500 new cases reported each week.Southern Ho Chi Minh City and Binh Duong, Long An and Quang Ngai were the most-hit localities, said the report.Meanwhile, dengue was also reported on the rise. In the first ten months of the year, there were more than 41,200 infected cases and 32 fatalities. Currently, an average of 2-3 cases a day were hospitalized by dengue infections, mainly from capital Hanoi.Epidemiologists said that the increase of HFMD and dengue was due to the lack of specialized medicine and preventive vaccines. In addition, complicated climate change, environment pollution and low awareness of the disease among the community have contributed to the spread of the diseases nationwide.
BEIJING, Nov. 20 (Xinhua) -- China on Sunday morning put two satellites into orbit from the Jiuquan Satellite Launch Center in northwest China's Gansu Province.The satellites, Chuangxin 1-03 and Shiyan Satellite 4 were launched on a Long March 2D carrier rocket at 8:15 a.m. Beijing Time, said a Xinhua photographer, who witnessed the whole process.The Chuangxin 1-03, developed by the Chinese Academy of Sciences, will be used to collect and relay water conservancy, hydrological and meteorological data and data for power supply and disaster relief from monitoring stations.The Shiyan Satellite 4 will be used for experiments on space technologies and environment probe. Developed by the Chinese Research Institute of Space Technology, it is the country's fourth technology experiment satellite.The launch was the 151th of China's Long March series of rockets. The Long March-2D is one of the derivations of Long March-2.China started development of modern carrier rockets in 1956, and Long March rockets have become the main carriers for China's satellite launching.
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