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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

BEIJING, Sept. 28 (Xinhua) -- Chinese State Councilor Liu Yandong met here on Wednesday with Paul Otellini, president and chief executive officer (CEO) of U.S. computer chip giant Intel Corp.Liu praised Intel's development strategy of expanding investment in China and showed appreciation for the company's support of the development of China's education sector as well as its commitment to good corporate citizenship.She briefed Otellini on China's 12th Five-Year Plan, the recent developments in education and the mechanism for China-U.S. High-level Consultation on People-to-People Exchange.Chinese State Councilor Liu Yandong (R) meets with Paul Otellini, president and chief executive officer (CEO) of U.S. computer chip giant Intel Corp, in Beijing, capital of China, Sept. 28, 2011.She said bilateral people-to-people exchanges have made great achievements, with extensive consensuses reached on cooperation in the areas of education, science and technology, culture, sports, women and youth in the last two years.She hoped Intel will give full play to its advantages and deepen cooperation with China's Ministry of Education, so as to make new contributions to bilateral people-to-people exchanges.

BEIJING, Aug. 16 (Xinhuanet) -- Almost one in four Chinese students aged between 12 and 14 have tried smoking, according to the results of a survey released by the Chinese Association on Tobacco Control (CATC).The survey, carried out among 38,839 students and 6,503 teachers from middle and high schools in 11 provinces across the country between May and June, showed that 22.5 percent of students aged between 12 and 14 had tried smoking and that 15.8 percent of middle and high school students smoke regularly."There are definitely quite a number of boy students in my class who smoke regularly as some have been found smoking outside campus during lunch break," said Li Xiaolan, an English teacher from a high school in Shanghai. The survey also found that 39 percent of students took their first cigarette from their classmates."It was quite common to smoke with my classmates at school and we usually smoked in toilets or in corners of the playground after lunch," said Zhou Guangrong, a 22-year-old university student from Guiyang, Guizhou province, who started smoking when he was 12.The majority of student smokers buy cigarettes themselves and about 76 percent of the adolescent smokers said that there is at least one cigarette shop within 200 meters from their school."When I was a student at middle and high schools, they were surrounded by cigarette shops," said Zhou who used to smoke two cigarettes per day in primary school and two packs per week in middle and high school."We're keen to show that more adolescents are starting smoking much younger than before, and that we need to minimize the number of young smokers," said Duan Jiali, secretary-general of the youth tobacco control commission under CATC. Duan added that teachers and parents should set a good example for teenagers by not smoking in front of them at school or at home, which is the most influential way of stopping adolescents from smoking.China banned smoking in 16 types of public indoor venues - including hospitals, schools, bars, restaurants and hotels - on May 1 in an attempt to curb tobacco use in the country with the world's largest number of smokers.Currently, there are more than 300 million smokers in China, and about 1.2 million people die from smoking-related diseases every year, accounting for one-fifth of the world's total, according to statistics from the World Health Organization."Meanwhile, about 540 million people are exposed to secondhand smoke, 48.9 percent of which are adolescents (from 15 to 19 years old)," said Xu Guihua, deputy director of the CATC."It's essential and urgent for us to control the number of adult smokers who potentially tempt adolescents to smoke."

BEIJING, July 14 (Xinhuanet) -- European music service Spotify is set to launch in the United States on Thursday, according to media reports.The streaming service will be available in the morning by invitation and through subscription."Spotify is a new way to listen to and manage your music, discover new tracks and share songs and playlists with friends – music whenever you want it, wherever you are," the company said in a statement.Spotify's streaming music and subscription service have long been popular in Europe since its launch in late 2008, and the company has been aiming for a US launch for nearly as long.Spotify has inked agreements with Sony Corp Music Entertainment, EMI Music, and Vivendi SA's Universal Music Group in the last few months. It is expected to close a deal with Warner Music Group by launch or soon after, according to a source.

SINGAPORE, July 6 (Xinhua) -- A team of researchers in Singapore has designed a tube with special robotic hands that allows doctors to perform surgery on a patient's inner organs without resulting in scars, local media reported on Wednesday.The special "robotic hands" were fixed to the tube to access a patient's stomach. Compared with traditional methods which use only one robotic hand, the new device known as master and slave transluminal endoscopic robot, or MASTER, is more nimble, thereby allowing complex operations, the Lianhe Zaobao reported.Louis Phee, an associate professor at the Nanyang Technological University who led the team of researchers, had spent six years to develop the gadget, which cut an eight-hour procedure to just 17 minutes, said doctors at India's Asian Institute of Gastroenterology.The gadget, still in the trial stage, has been tested earlier this month on three patients at the Indian hospital. It is also expected to be tried out in Germany and China's Hong Kong later. The patients can leave the hospital much sooner than they would have using traditional gadgets.Phee said he expected the gadget to be available on the market as early as three years from now, after going through clinical trials and getting the approval from authorities.He also saw a potential for the gadget to be used on other organs by cutting a small spit on stomach that allows the gadget to go through to access the site.