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SAN DIEGO (KGTV) -- Inclement weather beginning Monday and lasting through Thursday will bring cooler temperatures and rain to San Diego County amid a busy travel season. The first of a series of storms is set to arrive Monday, bringing rain and snow to the county. A second storm is due to bring another round of moisture Christmas night through Thursday. Between the two storm systems, light showers will occur, according to the National Weather Service. The first round of storms are forecast to dump as much as an inch of rain along the coast and in the mountains. RELATED: Check your San Diego County Forecast | Holiday traffic mapSnow levels will be between 5,500 and 6,000 feet through Monday, falling to near 5,000 feet early Tuesday. Snow accumulations between one and three inches are expected for elevations between 5,000 and 6,000 feet. Another storm arriving Christmas night and lasting through Thursday shows similar precipitation amounts, according to model data. The agency says the second storm is colder, which means it could have a greater impact in the mountains, including through the Cajon pass and I-8 across the San Diego County mountains. 1172

SAN DIEGO (KGTV) — Maverick has landed in San Diego!Eagle-eyed fans caught glimpses of actor Tom Cruise in Coronado Monday, on the set of the upcoming "Top Gun" sequel, "Top Gun: Maverick." The 56-year-old actor was spotted on a motorcycle (again) near the entrance of Naval Base Coronado by media and residents. But it's not a total surprise, as many were alerted to the possibility of filming last week, when the city posted "no parking" signs outside the base.RELATED:  500

SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) - Mission Beach residents and tourists could be getting some relief from dockless scooters speeding down the boardwalk as San Diego's summer season approaches.The Mayor's Office is working on an emergency ordinance banning electric scooters, like those used from services such as LimeBike or Bird, from the Mission Beach Boardwalk, from Crystal Pier south to the jetty."Residents have complained about [the] continued reckless use of motorized (electric) scooters along the Mission Beach Boardwalk. This type of behavior has resulted in collisions, accidents, and bodily injuries," the city said in a release.DOCKLESS TRANSPORT COVERAGE: 692

SAN DIEGO (KGTV) - Just ahead of this holiday week, San Diego's Cross Border Xpress (CBX) unveiled new biometric facial comparison technology. The CEO of the sky bridge that connects travelers directly to the Tijuana International Airport told ABC 10News that it will further secure and streamline travel into the United States.The U.S.-Mexico border is still closed to non-essential travel because of COVID-19. CBX CEO Jorge Goytortua said CBX is still not encouraging people to travel right now but if they do, they can take advantage of this technology.“Within seconds, the technology will recognize the passenger in a [Customs and Border Protection (CBP)] database,” said Goytortua. He told ABC 10News that the comparison process happens only at a time and place where travelers are already required by law to verify their identity by presenting travel documents. Goytortua says that when a traveler arrives at the CBP processing area, he or she will have a photo taken at the primary inspection point. A CBP officer will do a review by retrieving the traveler's passport or visa photo from government holdings. The new photo will be compared to the previously collected photo.“It's going to be a hands-free process. It's going to be a much faster process,” he told ABC 10News.He added that CBX does not have access to the photos. Only CBP officers can see them. If travelers are still concerned about privacy, he said it's not mandatory to use the technology. “You can ask the officer if you don’t want to be processed like that then you will be processed the traditional way with your document read it on the scan. A CBP officer [will] research on their system and make sure that the person that is presenting the document is the one there in front of the officer,” he stated. 1790

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