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梅州人流时间选择
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发布时间: 2025-05-28 07:26:20北京青年报社官方账号
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  梅州人流时间选择   

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

  梅州人流时间选择   

SAN DIEGO (KGTV) -- Dawn Hendon knows a thing or two when it comes to the big day for couples, she was a wedding planner then became an officiant over the past 10 years."It's a happy business, I like to be around people for joyous occasions and weddings are always a happy event so I thought this is a happy thing, and today we need all the joy we can find," Hendon said.Recently, she's added a backyard chapel at her San Marcos home to her list of services. "I even have shoes, accessories, floral head pieces, boutonnieres for guys and tuxedos for men."Love Wedding Chapel is what she calls it and she was able to pull it off thanks to help with a grant from the San Diego Black Chamber of Commerce. At a time she said when people are supporting more black owned businesses amid the fight for racial injustice, "I’m glad people are looking to support black owned businesses. Sometimes we have a lot more challenges, our population isn’t so big in San Diego." And in the middle of a global pandemic, Hendon said, "I’ve lost family members with COVID this year and I thought finding our joy is important so it brings me joy, and I hope to bring joy to others."She said there was no better time than now to create the business of her dreams, "I thought if we could bring a little bit of that dream to them and bring them a nice environment then it’d make their day a little special."She received her Masters in Business Administration last year and said everything she's learned and accomplished has helped make this business happen. "Resilience, following through and executive management. I use all my skill sets, it all comes in handy. I even sew, I even used to sew in undergrad so it all comes in handy."Couples are allowed up to 8 guests, all social distanced and Hendon said you can do it all from her backyard under 0. 1837

  梅州人流时间选择   

SAN DIEGO (KGTV) -- Deadly crashes rose in San Diego in 2018, according to a new report by the National Highway Traffic Safety Administration. According to the report, there were 240 deadly crashes in San Diego County in 2018.In 2017, 223 deadly crashes were reported countywide, the agency said. According to the data, January and July were the deadliest months in 2018, each with 28 fatal crashes. RELATED: San Diego rain could lead to more crashes on wet roadsThe month with the least fatalities was May in 2018. The report didn’t specify why exactly certain months had more deadly crashes than others. The U.S. as a whole, however, saw fewer deadly crashes, showing a 2.4 percent decline from 37,473 in 2017 to 36,560.The agency says 2018 marked the second year in a row of reduced crash fatalities. RELATED: San Diego not the worst US city to drive in, but not the best either“This is encouraging news, but still far too many perished or were injured, and nearly all crashes are preventable, so much more work remains to be done to make America’s roads safer for everyone,” U.S. Transportation Secretary Elaine L. Chao said. Also promising: the data show that deadly crashes among children 14 and younger declined more than 10 percent while alcohol-impaired driving fatalities decreased 3.6 percent. 1313

  

SAN DIEGO (KGTV) — Congressman Duncan Hunter and wife, Margaret, were arraigned Thursday in San Diego, where they entered their pleas to a 60-count indictment surrounding charges of campaign fund violations.Here are five fast facts to know about Thursday's arraignment:HUNTERS' PLEAThe Hunters both pleaded not guilty to the indictment handed down on Wednesday. Rep. Hunter has continued to plead innocent to charges against him since they were introduced in 2016.This week, Rep. Hunter called the indictment a "politically motivated" attack.HUNTER INDICTMENT: 573

  

SAN DIEGO (KGTV) — County health officials say with the summer months well underway, they've seen an uptick in the number of children that have needed to be rescued from private pools after nearly drowning.Officials say there have been 49 rescues in private pools, beaches, and bays from March through July, compared to 37 in the same period in 2019 and 33 in 2018. Nearly all of those rescued this year have needed to be taken to the hospital for treatment.Of those 49 that occurred this year, 28 were in pools and 14 were in the ocean, lakes, or bays. The rest did not report a specific body of water. Many public pools have been closed since March due to the pandemic."Parents and guardians must take the necessary precautions to keep these incidents from happening," said Wilma Wooten, county public health officer, said. "Children who swim in pools at home are at higher risk of drowning, especially as parents struggle to supervise their children while continuing to work at home through the summer months because of the novel coronavirus."The county says it's important to teach children to swim, never leave a child unsupervised in or near water, avoid alcohol if you're swimming, and learn CPR.At home, the county recommends installing a fence around the pool and hot tub, installing pool alarms, and keeping an eye on drains and pool toys that could be a tripping hazard. 1389

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