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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) - May is Maritime Month in San Diego and the best chance to learn all about San Diego Bay's regional importance for free!The Port of San Diego will offer free tours as part of its annual Maritime Month celebration. During May, the Port offers free bus and boat tours of San Diego Bay.Bus tours depart from Pepper Park in National City and will take guests on a tour of San Diego's shipbuilding and repair yards, the Tenth Avenue Marine Terminal (where the Dole ship often is) and National City Marine Terminal.RELATED: San Diego museum members get in free during 'Big Exchange'Bus tours are set for May 17 and 24 at 10 a.m. Seating is limited.Boat tours will depart on Hornblower vessels from Pier 1 in San Diego and travel through scenic San Diego Bay.Tours bring passengers to San Diego's shipbuilding and repair yard, and Tenth Ave. and National City terminals as well. The tour will also stop at the Port's Marine cargo terminal.RELATED: National Bike Month kicks off in San DiegoBoat tour dates are set for May 19 and 20 at 10:45 a.m. and 1:15 p.m. each day.For more information or to RSVP, visit the Port's website. 1156

SAN DIEGO (KGTV) — Local and federal authorities raided four San Diego County homes Wednesday as part of a money laundering investigation.Agents served one of those warrants at an El Cajon home at about 7 a.m., according to neighbors. Agents could be seen removing several items from the property. 10News observed agents searching through the first and second floors of the home. Neighbors told 10News agents made requests over a speaker for the home's residents to exit the property. Neighbors added that eventually, the announcements stopped and they heard what they described as a small explosion, before agents entered the home in tactical gear.RELATED: Ex-Wells Fargo banker indicted for money laundering appears in courtLauren Mack, with the Department of Homeland Security, told 10News the raid was one of five instances in which agents served search warrants as part of an investigation into a suspected money laundering conspiracy. Four locations were in San Diego County and one was in Los Angeles County.Federal agents worked with San Diego Homeland Security Investigations to serve the local warrants.No arrests have been made, according to Mack. 1166

SAN DIEGO (KGTV) — In a normal school year, thousands of San Diego families rely on after-school programs to help with child care and tutoring.But with schools going virtual this fall amid the pandemic, groups like the YMCA and the Boys & Girls Clubs plan to expand after-school programs into full-day operations to alleviate the burden on working families.“It’s a whole new world for us. And it’s a whole new world for families,” said Greg Erickson of the YMCA of San Diego County. “There has never been a greater demand for these types of programs than right now and so the Y has to be ready, and we will.”Beginning in August, the Y will ramp up staffing to offer full-day and half-day enrichment options for kids from kindergarten through middle school.The goal is to have kids in supervised activities from about 8 am to 4:30 pm, with half the day set aside for games and social enrichment and the other half supporting distance learning.“You can imagine a staff member with 10 kids in a classroom, each on a different Zoom call,” Erickson said. Staff members will not be credentialed teachers, he added, but the Y is interested in recruiting substitute teachers or college students studying education.The location of these childcare programs will vary across the county: some will be offered at YMCA facilities, some will be at school sites, and others will be at third-party facilities like community centers and churches.With demand for childcare expected to be high as long as school campuses are closed, the YMCA is actively scouting locations that can host enrichment programs for an indeterminate amount of time, Erickson said. The YMCA already serves about 15,000 kids in its after-school programs, said Association Director of Public Relations and Communications Courtney Pendleton.The YMCA expects to announce more specifics about the program this week, Erickson said. The cost to families is still being determined and will hinge on whether the YMCA is permitted to use state grants to offset expenses, he said.The Boys & Clubs of Greater San Diego said it planned to open select locations for all-day enrichment programs, “helping members with their distance learning activities in the morning and then transitioning to the traditional club programs in the afternoon,” said spokeswoman Ashley Schumacher.“Once local schools are able to resume in-person operations, we’ll revert back to an after school program,” she said, adding that more information about the clubs that will reopen would be available in early August. 2551

SAN DIEGO (KGTV) -- Marty Coyne snags the same prime spot at Campland on the Bay every Fourth of July weekend.He parks his massive RV right across from the water."Wouldn't trade it in for any other place to stay in the summer," he said Friday. "It's beautiful here, safe here, the grandkids can run free and have a great time."This year - however - the celebration is quite a bit different - due the outbreak of Covid 19.Campland on the Bay, on Mission Bay's north end, is like many hotels along San Diego's coastline. It's not totally booked.Elvin Lai, who owns the Ocean Park Inn in Pacific Beach, said he was booked in the high 60 percents at a time when the hotel is usually full. "It doesn't mean that I won't get last minute bookings but we're used to being sold out for the month of July months in advance, so it's different."On Friday at the campland, the mood was festive, but the activities were limited - the skate park and basketball courts were taped off. There won't be any bands for outdoor entertainment, and indoor dining is disallowed.Campland on the Bay also placed yellow cones on the beach to give people a clear path to the water. It's also requiring all tents to be spaced out by eight feet. Masks are required in public areas, and rangers are carrying around extra.Still, not every visitor was wearing a mask."Everybody doesn't follow it," said Barry Homer, who is staying on the grounds with his wife Cindy. "It'a always a problem everywhere in the world, for lots of reasons."Hotels and Campland are still open to last minute reservations."We anticipate it's going to be be like this no more than today and tomorrow, and then it'll go down to quiet as people go back to their normal lives," said Ahmed Aitlahcen, the campland's general manafger.The Auto Club predicts 107 million residents of the Pacific Coastal states will take trips this summer. That's down 17 percent from 2019. 1916