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Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

Tinder's parent company Match Group is suing competitor Bumble, accusing the female-friendly dating app of patent infringement and stealing trade secrets.The lawsuit, filed Friday in Texas, says Bumble is virtually identical to Tinder, the app that popularized the swipe right to like, swipe left to dislike functionality.Bumble copied the "world-changing, card swipe-based, mutual opt-in premise" of Tinder, the lawsuit says.The complaint also says that Bumble's co-creators are ex-Tinder employees, and the app has rolled out two new features that were "learned of and developed confidentially while at Tinder."Bumble has become a fierce competitor to Tinder since it launched in 2014. Bumble's differentiating factor is that only women can make the first move. But Match confirmed last month it plans to launch that feature in its own app.In the complaint, Match says it "applauds Bumble's efforts at empowering women, both in its app and offline" and "cares deeply both about its women users and about women's issues generally.""This case is simply about forcing Bumble to stop competing with Match and Tinder using Match's own inventions, patented designs, trademarks, and trade secrets," it says.The lawsuit is the first time that Match Group, which also owns dating sites Plenty of Fish and Match.com, has enforced the patents it secured on swiping and double opt-ins for dating matches on Tinder, according to a company spokesperson.Tinder and Bumble have had a complicated history.Bumble was launched by Whitney Wolfe Herd, an early employee at Tinder.Wolfe Herd left Tinder in 2014 after alleging sexual harassment and discrimination. The case was eventually settled. Ex-Tinder employees Chris Gulczynski and Sarah Mick joined Herd to start Bumble more than three years ago. Gulczynski and Mick, who are designers, are at the center of the stolen secret allegations in the suit.The two had knowledge of an "undo" button talked about at Tinder, according to the complaint. That feature was "nearly, if not literally, identical" to Bumble's backtrack feature, the lawsuit says. The backtrack feature allows users to go back in time to "like" someone they may have accidentally passed on.Gulczynski and Mick also helped implement photo messaging at Bumble, something Gulczynski had allegedly mocked up a design for while at Tinder.In a statement, a Match Group spokesperson said the company is "committed to protecting the intellectual property and proprietary data that defines our business,"Bumble did not immediately respond to request for comment. According to the Linkedin accounts for Gulczynski and Mick, both have left Bumble. They did not immediately respond to messages seeking comment about the lawsuit.Axios was first to report that Match Group had filed the suit.It's been widely reported that Bumble once turned down a buyout offer from Match Group. Match Group was reportedly still interested in Bumble's business as recently as November of last year.Match Group said it doesn't comment on mergers and acquisitions speculation.In an interview with journalist Gayle King at the SXSW festival last week, Wolfe Herd declined to talk about any conversations — past or present — with Match Group, the parent company of Tinder. 3251

There are more than 118,000 teens and children waiting to be adopted in the United States. Now, one group hopes to find parents for these children and using a new PSA to get attention.Isaiah lived in a foster home until he was 16 years old. Then, his social worker introduced him to Amy Arnston and her family."I knew I wanted to be part of their family as soon as I went there that weekend," Isaiah says.The couple had him over for Thanksgiving."They were pretty funny and outgoing people, so I got pretty comfortable with them after a while."A seat at that table turned into forever."I couldn't imagine not having my parents and my family in my life right now,” says Isaiah.However, many children Isaiah's age aren't so lucky.That's why AdoptUSKids is out with new PSAs, showing impactful moments of teenagers’ lives. Memorable moments parents play a big part in.The organization’s hope is more parents will look at adopting older children like Isaiah.They're hoping more parents will look at adopting older kids like Isaiah."[We] took him in as an Arntson. He became my son instantly," says Amy Arnston."There's a kid out there that needed that love that I needed when I was 16," Isaiah says. 1203

Treasury Secretary Steven Mnuchin asked the White House about the possibility of using a government jet for his European honeymoon this summer but later withdrew the request.A Treasury Department spokesperson told CNN in a statement that Mnuchin made the request to ensure he had access to secure lines of communication when he and his new wife, Louise Linton, were traveling."Treasury withdrew its request after a secure communications option was identified during the Secretary's extended travel," the spokesperson said Wednesday.Treasury said it has a practice of considering a "wide range of options" to ensure Mnuchin has access to secure communications, including the possible use of military aircraft.The Treasury spokesperson said it was "imperative" that Mnuchin, who is a member of the National Security Council and directly involved with national security issues tied to North Korea, Iran, and Venezuela, could communicate securely.ABC News was the first media outlet to report the Secretary's request.When asked if there was a review of the request, an official with the Treasury Department's Inspector General, which investigates allegations of wrongdoing within the agency, told CNN Wednesday "We are looking at all requests and uses of government aircraft."A White House spokesperson declined to comment and directed questions to Treasury.This is not the first time a trip by the former Goldman Sachs banker has raised eyebrows.Another trip by Mnuchin and his wife to Kentucky last month is already under review by the Treasury Department's Inspector General.Jaws dropped in August when Linton posted a picture of herself on Instagram stepping out of a U.S. government plane. She had tagged a series of luxury designers such as Hermes, Tom Ford and Valentino to describe her expensive clothing. Social media pounced on the post and called it ostentatious.Mnuchin's trip to Kentucky included a stop at a chamber luncheon in Louisville and Fort Knox, where he, and Senate Majority Leader Mitch McConnell, and others watched the Aug. 21 eclipse.The Treasury Department has previously defended Mnuchin's trip as "official government travel" and denied that viewing the eclipse was the primary purpose of the trip.Instead, the agency said the government aircraft was used to facilitate the secretary's travel schedule and ensure uninterrupted access to secure communications."The Department of the Treasury sought and received the appropriate approval from the White House. Secretary Mnuchin has reimbursed the government for the cost of Ms. Linton's travel in accordance with the longstanding policy regarding private citizens on military aircraft," a Treasury spokesperson told CNN earlier this month. 2746

TORRANCE, Calif. (CNS) - Police Monday announced the arrest of a 47-year-old parolee accused in the shooting deaths of three men during a fight at a bowling alley in Torrance.The arrest of Reginald Wallace of Los Angeles, who had been on parole since 2017 following a conviction for assault with a deadly weapon involving a firearm, was announced by Torrance police Chief Eve Irvine at a Monday afternoon news conference at police headquarters.Wallace was arrested early Sunday and was being held without bail at the Twin Towers Correctional Facility, according to sheriff's inmate records. Officers responded to a shots-fired call just before midnight Friday at Gable House Bowl, 22501 Hawthorne Blvd. Three men were pronounced dead at the scene and two others were taken to a hospital for treatment of their injuries. Two other men sought medical attention on their own.Irvine said a fight involving a few people grew into a brawl involving as many as 15. At some point, Wallace pulled a handgun from his pocket and fired into the crowd, Irvine alleged, adding that he was believed to have been the only shooter.Witness Dana Scott previously told reporters that a group of women got into a fight inside the building, then some men got involved. About a minute later, gunshots erupted, Scott said.Another witness, who refused to give his name, said a fight erupted and he heard nine gunshots.Wes Hamad, a 29-year-old Torrance resident, said he saw a ``huge fight'' break out that lasted about five minutes, blocked the entrance of the bowling alley and devolved into ``complete chaos.''``I grabbed my niece and started running toward the far end of the bowling alley,'' he said. ``As we were running, we heard 15 shots.'' Killed were Michael Radford, 20, and Robert ``Tank'' Meekins and Astin Edwards, both 28 and best friends. Meekins leaves behind a 5-year-old son, whose godfather was Edwards.``When I go home and tell him that his daddy's not coming back, it's going to break his heart because he's a daddy's boy, always has been,'' said Meekins' mother, Anglean Hubbard. ``And I wonder the person that sat up here and took all of these people's lives, how is he sleeping? How is he dealing with that? He took somebody's father. Somebody's son. I just want justice for my son and all the people in there.''Relatives of all three victims told reporters they believed the men were killed while trying to break up the fight. No employees of the bowling alley, a community fixture for about five decades, were injured, Harris said.Torrance Mayor Pat Furey described the shooting as ``horrible'' in a social media post.Rep. Maxine Waters, D-Los Angeles, issued a statement Monday morning saying she was ``deeply saddened'' to learn of the shooting at Gable House Bowl.``This shooting weighs heavily on my heart, as it took place right outside of my district in a bowling alley that should be a place for fun and celebration for members of our community,'' the lawmaker said. ``I extend my deepest sympathies to the victims, their families, and all those who have been impacted by this shooting. I would also like to thank the Torrance Police Department, first responders, and staff of the Gable House Bowl for their bravery and response to this incident.'' 3264

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