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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

MOSCOW, Oct. 3 (Xinhua) -- A Soyuz-2.1B rocket carried a Glonass-M navigation satellite into orbit early Monday after a two-day delay caused by high winds, a Russian Space Forces spokesman said."The launch of the booster rocket is as scheduled. The satellite Glonass-M was put into the orbit under control at 03:55 Moscow time (2355 GMT on Sunday)," said Colonel Alexei Zolotukhin.Zolotukhin told reporters that the rocket was launched at 0:15 Moscow time (2015 GMT, Sunday) from the Plesetsk Space Center in northern Russia.The Russian Space Forces said the launch was initially scheduled for Saturday but was postponed due to high winds.Glonass is the Russian equivalent of the U.S. Global Positioning System (GPS), which is designed for both military and civilian use. The system requires 24 operational and 2-3 reserve satellites in orbit to ensure global coverage.In December 2010, a malfunction of the booster resulted in a loss of three Glonass satellites.

SHANGHAI, Jan. 11 (Xinhua) -- China has allowed the Bank of East Asia (BEA) to issue yuan-denominated bonds in Hong Kong for a second time, about three years after it became the first foreign-invested bank to make a yuan bond issuance, the bank said Wednesday.BEA China Ltd, a wholly-owned subsidiary of the BEA, was given the approval by the National Development and Reform Commission of China to issue yuan bonds in Hong Kong, it said.Details on the amounts and timing of the offerings weren't available. In 2009, in a major landmark, the BEA issued its first yuan bonds in Hong Kong in an aggregate principal amount of 4 billion yuan (630 million U.S. dollars).The BEA was among the first foreign-invested banks to be given the green light to issue yuan-denominated bonds in Hong Kong, a move analysts say will bolster the international influence of the Chinese currency, also known as renminbi.Sun Minjie, deputy head of BEA China, said the second bond issuance will give the bank stable access to capital, improve its debt portfolio, and support its development on the Chinese mainland.

SAN FRANCISCO, Nov. 12 (Xinhua) -- Apple has unveiled a worldwide replacement program for the first-generation iPod nano music player due to overheating battery issues, telling owners to stop using the product and get it replaced for free."Apple has determined that, in very rare cases, the battery in the iPod nano (1st generation) may overheat and pose a safety risk. Affected iPod nanos were sold between September 2005 and December 2006," said Apple in a notice posted late Friday on the support section of its official website.The company said the issue has been traced to a single battery supplier that produced batteries with a manufacturing defect. Since the product is five or six years old now, the likelihood of an incident increases.Owners of iPod nano can check the serial number on the back of the product to see if it is eligible for replacement. Apple promises a replacement unit about six weeks after the company received the affected one.The overheating battery issues of the first generation iPod nano have been known for years. In 2008, Japan's Ministry of Economy, Trade and Industry launched an investigation into Apple after dozens of iPod overheating cases were reported, including several incidents of iPod nanos toasting to the point of catching fire and causing minor burns to owners.Last August, a commuter train in Tokyo was delayed during rush hour when passengers complained of a strong burning smell from an overheating iPod nano that had burst apart.The portable music player also cost Apple a 22.5 million-U.S. dollar settlement in 2009 when a class action lawsuit in California alleged iPod nano is prone to scratches and its alleged defects were not disclosed by the company.

BEIJING, Oct. 27 (Xinhuanet) -- A new study shows that it's not simply a lack of willpower that explains weight regain but hormones keep one insisting on eating, a persistent biological urge. As any dieter knows, it's hard to keep weight off. Weight regain is a familiar problem for dieters. The research appears in Thursday's issue of the New England Journal of Medicine. To study what drives it, Proietto and his colleagues enrolled 50 overweight or obese patients in Australia in a 10-week diet program. On average, the participants lost almost 30 pounds in the 10 weeks - faster than the standard advice of losing a pound or two per week. Even so, they gained an average of 12 pounds back over the next year. The scientists checked the blood levels of nine hormones known to influence appetite - and found that even a year after the end of the weight-loss program, six of the hormones were still out of whack. People who regain weight should not be harsh on themselves, as eating is our most basic instinct, study author Joseph Proietto of the University of Melbourne in Australia said. It's better not to gain weight than to try to lose it.