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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

HONOLULU, United States, Nov. 13 (Xinhua) -- Chinese President Hu Jintao and leaders of other Asia-Pacific Economic Cooperation (APEC) members met in Honolulu, Hawaii, Sunday to find ways to speed up regional economic integration, free trade and investment, and economic and technological cooperation.The annual meeting, hosted by U.S. President Barack Obama in his home state, is being convened at the JW Marriott Ihilani, Honolulu, to boost regional economic integration, trade, green growth, job creation in green industries, energy security, and regulatory cooperation.President Hu is expected to speak at the meeting. He will introduce China's stand on the topics and call for "improving global economic governance, shifting the growth methods, promoting economic globalization and regional economic integration," according to Chinese diplomats.Hu will join other APEC leaders in meeting with the APEC Business Advisory Council (ABAC), which presents recommendations to APEC leaders in an annual dialogue and advises APEC officials on business sector priorities and concerns.During this year's dialogue, APEC leaders are expected to discuss regional economic integrity, the development of small- and medium-sized enterprises, food security and other issues with ABAC representatives.This year's APEC meeting convenes at a time when the global economic recovery is fraught with instability and uncertainty, and encounters growing risks and challenges.Some major economies are experiencing an economic slowdown, while in the eurozone, sovereign debt risks are rising in some countries. High inflationary pressure is a problem in emerging economies, including some in the Asia-Pacific region. Protectionism in various forms is mounting.In face of the challenges, the APEC leaders will look for effective measures to stimulate the global economy, regional economic integration, free trade and investment, and economic and technological cooperation.China hopes the APEC members will implement the economic growth strategy agreed on last year, striving to achieve a balanced, inclusive, sustainable, innovative and safe economic growth, said Wu Hailong, assistant foreign minister of China, at a press briefing last week.He said that China expects the APEC members to comprehensively promote regional trade and investment liberalization, adding that all members should fulfill their commitments and oppose all forms of trade protectionism.APEC should strengthen economic and technical cooperation to enhance the ability of the developing members to develop further, and therefore to achieve common prosperity, said the senior diplomat."APEC members generally hold positive attitudes toward U.S. proposals in various fields such as green growth, innovation policy. But some of the U.S.'s expected outcomes are beyond the capacity of the developing members, and they have expressed their difficulties and concerns," Wu said.

HONOLULU, the United States, Nov. 12 (Xinhua) -- Chinese Commerce Minister Chen Deming has said that China-ASEAN Free Trade Area, launched at the beginning of last year, accords with the mutual interests of China and ten nations of the Association of Southeast Asian Nations (ASEAN) and brings advantage to both sides.Chen made the remarks during his meetings with Indonesian Trade Minister Gita Wirijawan and Thai Deputy Prime Minister and Commerce Minister Kittirat Na Ranong on Friday on the sidelines of the week-long Asia-Pacific Economic Cooperation (APEC) meetings held in Honolulu, Hawaii.According to information made available to Xinhua Saturday, Chen said in his meeting with Gita that China and Indonesia have witnessed a sound development of bilateral economic and trade relations. The China-ASEAN Free Trade Area has provided a new platform for the bilateral economic and trade cooperation, with more benefits and opportunities for enterprises from both countries.Chinese enterprises, especially those from the southern part of China, are keen to invest in Indonesia, said Chen, adding that China would like to discuss with Indonesia on creating areas similar to industrial parks so as to attract more Chinese enterprises and enterprises from other countries to invest in the Southeast Asian country.Gita said Indonesia will commit to the consensus reached between leaders of both countries to increase the volume of bilateral trade from current 34 billion U.S. dollars to 80 billion U.S. dollars in three or four years.He welcomed Chinese enterprises to invest in Indonesia, adding it will be conducive to the realization of the trade goal.Saying that the economies of Indonesia and China have been complimentary to each other, Gita expressed the will of comprehensive and long-term cooperation between both sides.During his meeting with Kittirat, Chen first expressed sympathy to the flood victims in the country, saying that China would like to offer assistance to the rescue and reconstruction efforts and strengthen cooperation in areas including infrastructure construction with Thailand.He said China and ASEAN nations should promote the substantial cooperation among member nations of the China-ASEAN free trade area, the largest free trade area in the world, improve infrastructure including highways, railroads, ports, telecommunication and electricity, so as to benefit the enterprises and people in the regions.China encourages enterprises to invest in the ASEAN nations and would like to conduct cooperation with enterprises from Thailand and other countries, Chen added.Kittirat, expressing his gratitude to China's help to the flood disaster, said that Thailand attaches great importance to the China-ASEAN Free Trade Area.Noting that Chinese enterprises are well-experienced in the construction of highways, railroads and bridges, he said Thailand welcomes Chinese enterprises to participate the construction and investment projects in these areas.

BEIJING, Nov. 7 (Xinhuanet) -- A huge asteroid will pass closer to Earth than the moon on Tuesday, but experts say there is no cause for alarm.Asteroid 2005 YU 55 will pass about 300-thousand kilometers from the earth. The giant space rock is about 400 meters in diameter. The close encounter will occur at 23:28 Greenwich Mean Time. Computer models showing the asteroid’s path for the next 100 years show there is no chance it will hit Earth during that time.Previous studies show the asteroid is what is called a C-type asteroid that is likely made of carbon-based materials and some silicate rock.

BEIJING, Dec. 19 (Xinhua) -- China will launch its first-ever high-resolution geological mapping satellite for civil purposes next January, according to official sources.The Ziyuan III satellite will be launched aboard a Long March 4B carrier rocket from the Taiyuan Satellite Launch Center in northern China's Shanxi province, according to a conference held on Monday for the directors of surveying, mapping and geoinformation administrations across the nation.The Ziyuan III's surveying covers the entire area between 84 degrees north latitude and 84 degrees south latitude.The satellite will be used to conduct geological mapping, carry out surveys on land resources, help with natural disaster-reduction and prevention, and lend assistance to farming, water conservation, urban planning and other sectors.The Ziyuan III satellite project was inaugurated on March 2008, and also includes gravity satellites, radar satellites and follow-up satellites for the Ziyuan III, so as to obtain geoinformation under all kinds of meteorological conditions.