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SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) — In a statement, the City of San Diego says it wasn't given enough time ahead of the July 4 weekend to close beach parking lots.Friday, California Office of Emergency Services sent a letter to city managers in the county asking them to close their beach parking lots ahead of the weekend. The letter was sent to officials in San Diego, Imperial Beach, Coronado, Del Mar, Solana Beach, Encinitas, Carlsbad, and Oceanside."At the time of writing, beaches under the jurisdiction of local governments within San Diego County are the only beaches without visitation restrictions throughout all of Southern California, and therefore are attracting thousands of residents from outside your coastal communities and creating significant potential for disease transmission, particularly in crowded restaurants, bars, retail, and hotels," the letter stated. "... To protect the public health of San Diegans and reduce the high potential transmission of this deadly disease in San Diego coastal businesses, we write to request that municipal governments do not open beach parking lots for the July 4th holiday weekend."RELATED: Crowds flock to San Diego beaches for Fourth of July weekendOceanside announced it would close beach parking lots on Thursday, while Carlsbad said late Friday that it would do the same. California also said Friday that state beach parking lots would be closed this weekend. Carlsbad said they were closing parking lots in anticipation of people traveling to San Diego for the weekend. Surrounding counties Los Angeles, Orange, Ventura, and Santa Barbara have closed beaches this weekend.City of San Diego Chief Operating Officer Kris Michell said in a statement to City News Service that San Diego wasn't given enough time to put a beach parking closure in place."The city of San Diego is closely following county guidance and working with health officials to encourage adherence to public health regulations," Michell said. "The request to regional coastal cities to close beach parking lots on the Fourth of July came last night just a few hours before the start of the holiday, leaving little time to enact, enforce or notify the public.RELATED: Carlsbad closes beach parking lots for holiday weekend"San Diego continues to require facial coverings and physical distancing at all locations, and this week voluntarily implemented restrictions on bars and restaurants to limit the spread of COVID-19," Michell said. "As we have since the beginning of the pandemic, we will continue to work with county and state health officials to protect public health and safety."Imperial Beach, Coronado, Del Mar, Solana Beach, and Encinitas officials said Saturday their beach parking lots remained open Saturday.Friday, several beaches were already seeing crowds for the holiday weekend. Many people claimed their spots early at Mission Beach and Oceanside.RELATED: Hotels, campgrounds have vacancies over holiday weekendWhile some were able to keep their distance from one another, many did not have on facial coverings when near other people, according to Rich Stropky, Marine Safety Lieutenant for San Diego lifeguards.“The majority of them are not wearing masks, I would say at this point in time,” said Stropky. “As far as the capacity for our beaches, what has limited capacity in the past is the ability to park. How far are people willing to park and still walk to the beach? Are they going to Uber in? Are they going to do drop-offs?”Law enforcement agencies have said they will focus on educations, rather than enforcement, of public health orders this weekend. 3604

SAN DIEGO (KGTV) — It's been a tumultuous year for East Village's Monkey Paw Brewery.The local brewing company was purchased by Coronado Brewing Company in July 2017, put up for sale in May of this year, and closed its downtown San Diego brewpub Monday.Coronado Brewing Company (CBC) CEO Brandon Richards said in May, months after finalizing the purchase, the sale was part of a refocusing for CBC.RELATED: Miramar's Intergalactic Brewery is closing its doors"While we were excited about the potential of Monkey Paw, the decision to sell came from the need to refocus our energy toward Coronado Brewing," Richards said. "We’re confident that the award-winning Monkey Paw brewery has brand equity that can be of value to someone looking to enter the craft industry."CBC said they would keep the downtown brewpub open while fielding offers for Monkey Paw.However, Richards told 10News Tuesday they are still looking for a buyer for the brand and are now determining the best use for Monkey Paw's former space.Richards added that CBC is currently producing Monkey Paw beers on an as needed basis.RELATED: Novo Brazil Brewing announces new?Chula Vista locationMonkey Paw had amassed a list of awards, including wins at the San Diego International Beer Competition, Los Angeles International Beer Festival, Great American Beer Festival, and World Beer Cup.Though soon after CBC's purchase of the brand, Monkey Paw's founder Scott Blair filed a lawsuit against Monkey Paw for breach of contract, according to Brewbound.Blair claimed Monkey Paw owed him ,534, plus interest, as part of a promissory note. Blair said he had not received any payments, which were to be made monthly, since Oct. 2017.At the time CBC announced the sale, Richards told Brewbound the decision was not a result of the pending lawsuit. 1859

SAN DIEGO (KGTV) - Local supporters of both Joe Biden and Donald Trump were watching the election vote count closely throughout Friday.Ellen Nash, who heads the San Diego chapter of the Black American Association of Califorina, a minority advocacy group, put up her Biden/Harris yard sign about a month ago.During the election season, she helped organize a voter registration campaign. Since election night, it's been a constant case of the nerves."Incredibly excited, praying night and day," said Nash.Her eyes have been glued to the television and coverage of the vote count. Throughout Friday, her candidate edged closer to being declared the winner."I will feel relieved that the trauma is over. I'm speaking as a black woman who has been under significant trauma the last four years, in terms of some of the language and behavior of the leader of the free world. Hopeful change is coming," said Nash.There is no questioning her dislike of President Trump, but on this day, she is focused on the country’s future."I believe Biden can bring this country together. I believe he can help us heal as a nation," said Nash.It's a different opinion for local Trump supporter, Blake Marnell.During the campaign, Marnell garnered national attention for wearing a brick wall suit, illustrating his support of President Trump’s border security policy. Trump even called him up on stage, as Marnell attended some 15 rallies where the president appeared."He has the right to make these legal moves. He shouldn't be conceding ... mainstream media can do anything they want in terms of calling an election. That doesn’t make it so," said Marnell.Marnell backs Trump's vow to press on with recount and lawsuits involving his claims of voting fraud. After Trump spoke Thursday, some criticized him for alleging fraud but providing no evidence."It would be irresponsible to produce evidence of fraud in a press conference. The time and place for producing evidence would be in discovery in any court proceedings ... The vote count is not ideal, but I'm still hopeful," said Marnell.Marnell plans to attend a weekend Trump rally in Phoenix. He also attended a rally in Las Vegas Wednesday."I would go to show my support for the president. He has fought long and hard for us over the past for years, and I don’t intend to abandon the fight for him," said Marnell. 2355

SAN DIEGO (KGTV) - In a few days, the San Diego Air & Space Museum will become the first museum in Balboa Park to reopen amid the pandemic."Very, very anxious to get back to business ... We are ready to go," said Jim Kidrick, President of the San Diego Air & Space Museum.Among the precautions: masks, social distancing, and fewer people. The museum will be at operating at 30% visitor capacity. You'll see hand sanitizer everywhere and a lot of plexiglass when interacting with staff."We want to make sure guests not just visually feel good, but also feel good as they experience the Air & Space Museum," said Kidrick.One of the big challenges for any museum will be visitor interactions with exhibits and touchscreens. Here, each visitor will be handed a stylus pen."Any moment with interactivity where they would normally push with their finger, they can push with their stylus," said Kidrick.One precaution visitors won't see will happen at the staff entrance. Employees will be funneled toward a mounted, state-of-the-art thermal imaging scanner."You walk up to it and frames your face. It takes a temperature and gives you a pass or fail," said Kidrick.The museum opens its doors at 10 a.m. on Friday, the first day museums, zoos, and other entertainment businesses can reopen in California. 1317