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BEIJING, May 10 (Xinhuanet) -- Professional social networking site LinkedIn is aiming for a valuation of 3.3 billion U.S. dollars for its initial public offering, media reports said Tuesday.The Mountain View, California-based company is expected to begin trading on the New York Stock Exchange within the next month and will use the symbol "LNKD."It plans to offer 7.84 million shares priced at 32 dollars to 35 dollars each, according to the filing, which it submitted to the Securities and Exchange Commission.LinkedIn, which has more than 100 million members in over 200 countries and territories, is seeking to raise as much as 274.4 million dollars from the initial public offering (IPO) with 146.6 million dollars going to the company itself.In 2010, LinkedIn made 15 million dollars in profit on 243 million dollars in revenue, according to the filing.LinkedIn's biggest shareholder is its founder and chairman, Reid Hoffman, who owns more than 21 percent of the company.
WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

CHANGSHA, Jan. 25 (Xinhua) -- More than 8,000 fake goods were destroyed Tuesday in central China's Hunan Province, as part of Chinese efforts to protect intellectual property rights (IPR).Supervised by Changsha customs official, trucks rolled over a huge pile of counterfeit electronic devices in the city, the provincial capital.The trucks crashed imitation Nokia, Motorola and Apple laptop computers, cell phones, earphones and compact discs.Pirated books and Gucci handbags were incinerated.Changsha customs have confiscated more than 34,000 fake items worth 1.3 million yuan (197,470 U.S. dollars) over the past two years, said Liu Zili, a customs official.Some confiscated fake goods were donated to Red Cross societies and quake-devastated regions, in accordance with China's IPR protection regulations.
BEIJING, Jan. 30 (Xinhua) -- As of Jan. 28, 77.4 million mu (5.16 million acres) of crops had been harmed by the ongoing drought, and 2.57 million people were faced with drinking water shortages in China, the national drought control authorities said Sunday.Local governments of the affected regions must make efforts to monitor drought conditions, speed up the building of water projects, increase drought-fighting material reserves and grant subsidies to the drought-stricken population, said officials at a meeting attended by Chen Lei, deputy head of the Office of State Flood Control and Drought Relief Headquarters (SFDH).The National Meteorological Center (NMC) forecast the drought to worsen in the next two months, saying Sunday that the drought-hit north China and regions along the Yellow and Huaihe rivers would receive little rain or snow in February and March.Chen, also minister of water resources, stressed the importance of drought relief efforts, guaranteeing agricultural production and ensuring drinking water safety for boosting consumers' confidence, controlling consumer prices and inflation and maintaining economic growth.Since last Autumn when the drought began, local authorities have assigned 9.55 million people and 2.15 million sets of drought-fighting machineries to draw 8.2 billion cubic meters of water to irrigate 110 million mu of crop land.
BEIJING, Jan. 24 (Xinhua) -- China's top economic planner said Monday that price supervision and control measures have achieved steady progress with 2010's Consumer Price Index, slightly exceeding the target ceiling by 0.3 percentage points to hit 3.3 percent.To rein in soaring commodities prices, joint efforts have been made to manage inflation expectations, promote production, ensure supplies and strengthen price supervision in 2010, said the National Development and Reform Commission (NDRC) in an online statement.Prices of necessities accelerating during the second half of 2010 have been contained with vegetable prices down 9.4 percent in December from the previous month last year, it said.Further, prices of edible vegetable, pork, egg, sugar,liquefied petroleum gas and clothing also decreased significantly in December month on month, the statement said.To cope with rising prices beginning in July 2010, especially prices of basic supplies, the central government promptly introduced joint inter-ministerial meetings to discuss price controls among 17 ministries and ordered local governments to establish the same mechanism, it noted.Local governments have worked on improving agricultural facilities, especially in south China's Hainan province, to increase vegetables supplies for northern cities over the past year, the statement said.The statement forecasts that vegetable planting areas in 2010's autumn and winter will increase 530,000 hectares year on year, sending output to 337 million tonnes.To ensure production and supply, departments have worked to reduce fertilizer exports and promote links between production areas and purchasing areas, it added.Further, relevant authorities also took measures to stabilize prices of electricity and coal, and to ensure smooth transportation of agricultural produce.Authorities also granted temporary subsidies and raised basic wages and minimum living subsidies for urban and rural residents to guarantee people's daily life.
来源:资阳报