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SAN DIEGO (KGTV) — Construction crews have started on about 4.5 miles of bikeways and safety improvements stretching from downtown to Hillcrest.The projects include separated and buffered bikeways on Fourth and Fifth Avenues, safety improvements such as lighting, upgraded landscaping, and improved crosswalks for people with disabilities and pedestrians.In all, the project will cost .2 million and cross from B St. in downtown, through Bankers Hill, and to Washington St. in Hillcrest."This project will make it safer and easier for people to walk and bike along commonly traveled streets to visit local businesses and reach destinations such as Downtown San Diego, Balboa Park, and Hillcrest," said SANDAG Vice Chair and Encinitas Mayor Catherine Blakespear. "San Diegans are walking and biking more during the pandemic and this project will provide safe and convenient options for people to continue to choose active transportation, even when the health crisis is far behind us."The new bikeways are part of the Uptown Bikeways effort proposed in 2012, meant to connect Uptown, Old Town, Mission Valley, Downtown San Diego, North Park, and Balboa Park. SANDAG says community members worried about the potential loss of parking due to the project worked with officials to find solutions, and ultimately were able to provide a surplus of parking.The agency adds that it has modified construction schedules to best minimize its impact on businesses currently using temporary outdoor setups to operate under coronavirus restrictions along Fourth and Fifth Avenues.Construction on the project is expected to be finished in 2022. During construction, nearby residents and businesses can expect intermittent lane closures, parking restrictions, construction noise, and dust. Most work will be completed Monday through Friday, holidays excluded, between 7 a.m. and 5 p.m., and occasionally on Saturdays. 1910
SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Custom churros are the latest foodie find on Kearny Mesa's bustling Convoy Street culinary scene.Churreria is taking the classic dessert treat and adding their own twist. The churro stop gives customers the chance to customize their churro with toppings like bacon, coconut, and even fruity pebbles. Better yet, churros are made right before customers' eyes.Nicholas Tran, owner of Churreria, said the idea for a churro shop developed after a trip by the border.RELATED: 10 must-eat restaurants on San Diego's Convoy Street"We saw this kiosk and they were having these churros from this little stand. And I was 'Oh my god. That's a fantastic idea,'" Tran said. "Everyone loves churros!"Tran's wife and his business partner embarked to Spain to develop how they would make their churros. The main difference, Tran, said is the basic ingredients.Traditional North American churros contain egg, milk, and butter. Spanish churros, though, are made from just flour, water, salt, and oil."It's vegan and vegetarian. It's good for people who are lactose intolerant or who have a dairy intolerance or with eggs," Tran. "This happens to be a healthy churro. What you put as your toppings I can't guarantee."RELATED: Top 7 dessert spots in San DiegoEnter the customizable feature of Churreria. Customers order whether they want their churro stuffed with Nutella or sweet cream or not, and then they can choose from different glazes and toppings, including sprinkles, nuts, and cookie crumbs."There's nothing to hide. We want to show you we make it from scratch and it's clean," Tran said.Another fun aspect of Churreria is its sustainability arm.Tran worked with his business partner to do something good with their cooking oil after use. The pair settled on donating the used oil to two areas: A local company that repurposes cooking oil into biofuel and a shelter that uses the oil for soap for homeless individuals."We try to put back into the community instead of just dumping the grease ... and having it hauled away," Tran said. "We're trying to be better for the environment that way." 2164
SAN DIEGO (KGTV) - Another storm arrived San Diego County Wednesday, putting fire-ravaged communities at risk of flooding. Cal Fire and county officials made free sandbags available to protect homes and property.Residents should check their homes to make sure drainage areas are clear of debris. Rain can also cause erosion in areas stripped of landscaping.Anyone who needs sandbags should check the list of locations provided by County Newscenter and call ahead for availability. County officials also say you should bring a shovel to fill your own bags with sand.Sand and BagsBonita/Sunnyside: 4900 Bonita Road, Bonita, CA 91902 P: 619-479-2346Boulevard: 40080 Ribbonwood Road, Boulevard, CA 91905 P: 619-390-2020De Luz: 39524 Daily Road, Fallbrook, CA 92028 P: 760-728-3140 *(Not staffed 24/7)De Luz: 39431 De Luz Road, Fallbrook, CA 92028 P: 760-728-2422Fallbrook: 4375 Pala Mesa Drive, Fallbrook, CA 92028 P: 760-723-2024Lakeside River Park Conservancy:12108 Industry Road, Lakeside CA 92040 P: 619-443-4770 *(Closed over the weekend)Palomar Mountain: 21610 Crestline Road, Palomar Mtn., CA 92060 P: 760-742-3701Ramona: 3410 Dye Road, Ramona, CA 92065 P: 760-789-0107Ramona: 24462 San Vicente Road, Ramona, CA 92065 P: 760-789-9465Rincon: 16971 Highway 76, Pauma Valley, CA 92061 P: 760-742-3243Valley Center: 28205 N. Lake Wohlford Road, Valley Center, CA 92082 P: 760-751-7605Warner Springs: 35227 Highway 79, Warner Springs, CA 92086 P: 760-782-9113Bags OnlyAlpine: 1364 Tavern Road, Alpine, CA 91901 P: 619-445-2635Deer Springs: 1321 Deer Springs Road, San Marcos, CA 92069 P: 760-741-5512Campo: 31577 Highway 94, Campo, CA 91906 P: 619-478-5516Campo (Lake Morena): 29690 Oak Drive, Campo, CA 91906 P: 619-478-5960Deer Springs: 8709 Circle R Drive, Escondido, CA 92026 P: 760-749-8001Deer Springs: 10308 Meadow Glen Way East, Escondido, CA 92026 P: 760-751-0820De Luz: 39431 De Luz Road, Fallbrook, CA. 92028 P: 760-728-2422Descanso: 24592 Viejas Grade Road, Descanso, CA 91916 P: 619-445-7508 (currently out of bags)Dulzura: 17304 Highway 94, Dulzura, CA 91917 P: 619-468-3391El Cajon: 551 Harbison Canyon Rd, El Cajon, CA 92019 P: 619-445-5001Escondido: 9127 W. Lilac Road, Escondido, CA 91916 P: 619-445-7508Jacumba: 1255 Jacumba St., Jacumba, CA 91934 P: 619-766-4535Jamul (Deerhorn): 2383 Honeysprings Road, Jamul, CA 91935 P: 619-468-3030Jamul: 14024 Peaceful Valley Ranch Rd, Jamul, CA 91935 P: 619-669-6580Julian: (Shelter Valley) 72160 Great Southern Overland, Julian, CA 92036 760-765-0155Mount Laguna: 10385 Sunrise Highway, Mt Laguna, CA 91948 P: 619-473-8281Ocotillo Wells: 5841 Highway 78, Borrego Springs, CA 92004 P: 760-767-7430Pine Valley: 28850 Old Highway 80, Pine Valley, CA 91962 P: 619-473-8445Portrero: 25130 Highway 94, Potrero, CA 91963 P: 619-478-5544Ramona: 829 San Vicente Road, Ramona, CA 92065 P: 760-789-8914Ramona: (Intermountain) 25858 A Highway 78, Ramona, CA 92065 P: 760-789-3710Ramona: (Mount Woodson) 16310 Highway 67, Ramona, CA 92065 P: 760-789-1150Ranchita: 37370 Montezuma Valley Road, Ranchita, CA 92066 P: 760-782-3467 *(Not staffed 24/7)San Pasqual: 17701 San Pasqual Valley Rd, Escondido, CA 92025 P: 858-573-1322Warner Springs: 31049 Highway 79, Warner Springs, CA 92086 P: 760-782-3560 3251
SAN DIEGO (KGTV) — COVID-19 related hospitalizations are on the rise in San Diego County and some healthcare workers are worried we will continue to see a significant increase over the next several weeks to months.“We’re actually seeing significant increases,” said Dr. Ghazala Sharieff, Scripps Health Chief Medical Officer for Clinical Excellence and Experience. “We’re actually higher than we were back in July. Yesterday alone the numbers we got from the county we had 532 hospitalizations across the region.”The total number of positive COVID-19 cases in the county is now 75,305. According to county data, 4,470 of all COVID-19 cases have required hospitalization, and 1,006 had to be admitted to an intensive care unit.Sharieff said Wednesday at Scripps campuses, more than 100 people were hospitalized with COVID-19.“We had 117 cases that is with 16 discharges, so if we weren’t able to send home those patients yesterday, we would be at our peak level in July,” she said.She said the concern is growing from those in the medical field, not only after local Halloween parties locally, but as we enter Thanksgiving and the next several holidays.She expects the numbers to continue climbing into early 2021.“What we’re seeing now is what we have predicted,” she said. “We do worry that two or three weeks out from now that we’re going to see the number increase as well.New Year’s Eve is December 31st; if you calculate just exactly what we’re seeing now, people start getting sick in that first two weeks, because the incubation period is two to fourteen days after exposure, then they get really sick and hospitalized, and then the intensive care unit comes, so I’m very worried.”Like many healthcare systems, she says Scripps is seeing a surge in hospitalizations countywide, but even more in the South Bay, where Covid-19 has hit the community hard.Scripps has a detailed plan in place and has managed to balance hospital capacity by transferring patients to different hospitals to not overwhelm a specific location.“Every day, between 4 to 5 patients are getting transferred out of the Chula Vista campus,” she said. “Yesterday we had five transfers, this morning we had two from Chula Vista to Green, and two from Mercy Chula Vista to La Jolla. We don’t want all of the strain to go on our staff in one place when we have capability elsewhere.”“It’s really hard on the healthcare providers when we’re out there trying to save lives, and we see people taking risks like they don’t have to take right now,” she said. “It’s a punch in the gut every time.”Sharieff said the hospitals are well equipped with PPE this time around, but while many people may be letting their guards down and gathering this Thanksgiving, she’s reminding everyone that this pandemic isn’t over and will get worse if we don’t act now.“Just one thing that you do can impact so many lives afterward,” she said. 2901
来源:资阳报