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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

UNITED NATIONS, Oct. 17 (Xinhua) -- China on Monday underlined the importance of safeguarding the peaceful use of outer space and preventing the weaponization of and an arms race in outer space, saying that "the outer space is the common wealth of mankind as the global public space."The statement came as Wang Qun, the Chinese ambassador for disarmament affairs, was taking the floor at the thematic debate on outer space at the First Committee of the UN General Assembly. The First Committee is in charge of disarmament and international security."The outer space is the common wealth of mankind as the global public space," Wang said. "The permanent peace of outer space is correlated to all nations' security, development and prosperity.""Meanwhile, with the growing reliance of mankind on outer space, the risk of the weaponization of and an arms race in outer space are on rise, and the uncertainties concerning outer space security are accumulating as well," he said. "Safeguarding the peaceful use of outer space and preventing the weaponization of and an arms race in outer space are common interest and obligations of all countries."In responding to the growing challenge for security in outer space, the international community also witnessed common grounds on opposing to the weaponization of outer space and advertising the Prevention of an Arms Race in Outer Space, he said.The General Assembly, for consecutive years, adopted " Prevention of an Arms Race in Outer Space" resolution by overwhelming majority of votes, calling for negotiations on an international legally-binding instrument on the prevention of an arms race in outer space at the Conference on Disarmament in Geneva."The mankind has marched into the 6th decade of outer space exploitation, and the manned space flight has made a history of 50 years," Wang said."Recently, China has successfully launched the Tiangong-1 ( Heavenly Palace 1) as a target spacecraft for rendezvous and docking experiment, which opens a new era of China's manned space flight, and also reflects that China is committed itself to the honorable objective of promoting the peaceful exploration and utilization of the outer space, maintaining peace and bringing benefit to mankind."

SAN FRANCISCO, Oct. 5 (Xinhua) -- Apple co-founder and longtime Chief Executive Officer Steve Jobs passed away on Wednesday."Steve died peacefully today surrounded by his family," Jobs' family said in a statement."We are grateful for the support and kindness of those who share our feelings for Steve. We know many of you will mourn with us, and we ask that you respect our privacy during our time of grief," said the statement.Apple's website has changed to "Steve Jobs: 1955-2011," along with the most iconic picture in which the scraggly bearded charismatic visionary posed with one hand up to his chin.Photo taken on Oct. 5, 2011 shows photo of Steve Jobs on the front page of www.apple.com. Apple Board of Directors announced that co-founder and former Chief Executive Officer Steve Jobs passed away on Wednesday"Apple has lost a visionary and creative genius, and the world has lost an amazing human being," the company said in a statement. "Those of us who have been fortunate enough to know and work with Steve have lost a dear friend and an inspiring mentor. Steve leaves behind a company that only he could have built and this spirit will forever be the foundation of Apple."Apple are asking for "thoughts, memories and condolences" to be shared by emailing rememberingsteve@apple.com.Apple Board of Directors also said in a statement that "Steve's brilliance, passion and energy were the source of countless innovations that enrich and improve all of our lives. The world is immeasurably better because of Steve."According to a memo sent by CEO Tim Cook, Apple is planning a celebration of Jobs' life for employees that will take place soon.Jobs took a medical leave of absence earlier this year, the third in his battle with pancreatic cancer that began in 2004. On Aug. 24, he stepped down as Apple CEO, saying "I have always said if there ever came a day when I could no longer meet my duties and expectations as Apple's CEO, I would be the first to let you know. Unfortunately, that day has come."Jobs recommended former CEO Tim Cook take his place as CEO. On Tuesday, Cook gave his first product announcement as CEO unveiling the new iPhone 4S.

BEIJING, Jan. 7 (Xinhua) -- China's land supply went up 37 percent year-on-year in 2011 amid the government's tightening measure on commercial property market, according to the Ministry of Land and Resources (MLR) on Saturday. Most of the land supply last year went to the country's 10 million government-subsidized affordable housing units that began construction in 2011, according to MLR.In the meantime, land supply for commercial residential housing totaled about 96,700 hectares last year, up only 4 percent from previous year.Planned land supply quota for construction last year were up 16.25 percent year-on-year from 180,000 hectares in 2010.

ULAN BATOR, Dec. 1 (Xinhua) -- Mongolia will continue to curb the spread of HIV and strive to maintain a low prevalence of the AIDS epidemic, a government official said Thursday.Gansukh Battulga, an official with the National Committee on AIDS, told Xinhua that Mongolia is currently an HIV low-prevalence country with a total of 99 people, 15 of whom have died, infected with the virus that causes AIDS."Among the 99 HIV infected cases, 81 percent are men, and the remaining 19 percent are women," Battulga said. "Among the male infected cases, 83 percent belong to MSM (men who have sex with men) group while sex workers account for 54 percent of the female infected cases."The official said the government has launched a variety of programs and tasked the National Committee on AIDS to coordinate all organizations in fighting the epidemic.According to a National Strategy Plan for 2010-2015, Mongolia will strive to maintain its current low HIV-prevalence rate of below 5 percent in the most-at-risk population.