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The weather at the beginning of November and the end of October are going to look very different across the country.Temperatures in the eastern half of the country, except the Northeast, took a big drop and even saw some snow. At the same time, the West Coast was dealing with some record-breaking heat. 311
The US Food and Drug Administration on Thursday announced the approval of?the first generic version of EpiPen.The auto-injector pen delivers the drug epinephrine to patients experiencing a severe allergic reaction that, if untreated, could develop into the life-threatening condition of anaphylaxis. The medication is delivered into a muscle as a single dose, like a shot, through an injector pen with a spring.Allergies from food, bug bites, medications and latex can cause life-threatening reactions.The newly approved generic is made by Teva Pharmaceuticals and offers an alternative for patients who, until now, have been able to use only the brand-name EpiPen made by Mylan. It is approved in a smaller dose for children, as well.There are two other brand products on the market for a severe allergic reaction: Adrenaclick and Auvi-Q.The newly approved option made by Teva is the only approved non-brand option and can be substituted only for Mylan's EpiPen."Today's approval of the first generic version of the most-widely prescribed epinephrine auto-injector in the U.S. is part of our longstanding commitment to advance access to lower cost, safe and effective generic alternatives once patents and other exclusivities no longer prevent approval," FDA Commissioner Dr. Scott Gottlieb said in a statement announcing the approval.In recent years, Mylan came under fire for a price increase that put the product out of reach for many who needed to keep the drug on hand. 1488

The White House is again rejecting calls for a national mask-wearing mandate.White House chief of staff Mark Meadows says in an appearance on “Fox and Friends” Monday morning that the president sees the issue as a “state-to-state” matter.He says that, “certainly a national mandate is not in order” and that “we’re allowing our local governors and our local mayors to weigh in on that.”New Jersey’s Democratic Gov. Phil Murphy has said he’d like to see a national strategy on the coronavirus, including a mask requirement. He says his state is seeing “small spikes in reinfection” from residents coming back from Florida, South Carolina and other virus hotspots, and the U.S. is “as strong as our weakest link right now.”Vice President Mike Pence has also rejected the idea of a national mandate, saying that’s up to governors and local health officials. 862
The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722
The UK will expel 23 Russian diplomats from the country after concluding that the Russian state is responsible for the attempted murder of former Russian spy Sergei Skripal and his daughter Yulia in the English city of Salisbury.This will be the single biggest expulsion of Russian diplomats in over 30 years, Prime Minister Theresa May said Wednesday. The 23 concerned, who May said had been identified as undeclared intelligence agents, will have only one week to leave."For those who seek to do us harm, my message is simple. You are not welcome here," she said in a statement to the House of Commons following a meeting of Britain's National Security Council.The expulsion of diplomats will "fundamentally degrade" Russian intelligence capabilities in Britain for years, May said.The Skripals are critically ill in hospital after being exposed to the nerve agent, known as Novichok and developed in Russia, on March 4. Thirty-eight other people in Salisbury were seen by medics after the exposure. One, a police officer, remains hospitalized.May said Monday it was highly likely that Moscow was behind the poisoning. The Russian ambassador to the UK was summoned to the UK Foreign Office to explain whether the attack was directed by Russian authorities, or whether Moscow had lost control of the nerve agent.She demanded that Moscow respond by midnight Tuesday, London time, to the UK government's conclusion that Russia was linked to the poisoning of Sergei Skripal and his daughter Yulia on a park bench in Salisbury in southern England.But Moscow -- which has repeatedly dismissed any accusations of involvement in the attack -- ignored the deadline. 1672
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