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A surge in COVID-19 cases is further straining the already-depleted supply of prescription drugs in the U.S., according to researchers and doctors at the University of Minnesota."The supply lines are really stressed and stretched," said Dr. Stephen Schondelmeyer, a co-principal investigator for the Resilient Drug Supply Project at the University of Minnesota.Schondelmeyer's work focuses on critical drugs and their supply chains. He tracks the supply chain process for every drug on the marketplace — more than 100,000 in total.Most of the prescription drugs used by Americans are made outside of the country — meaning the U.S. is reliant on foreign companies to manufacture the drug and shipping companies to deliver them safely."We're identifying where it comes from — the first thing you need to know is about 70% of all the drugs that come into the U.S. marketplace are made outside of the US.," Schondelmeyer said.He and his team want to predict and identify when and where there will be failures in the system. Right now, the U.S. has a "fail and fix" system — and right now, there are some critical breakdowns in the supply chain."Seventy-five percent of the COVID-19 drugs are currently in shortage," Schondelmeyer said. "That means three-fourths of the drugs we're using for COVID-19 were already in shortage, and that's before we had this last surge we're seeing.""We should, as a matter of national policy, have a map like we're building of the global drug supply from the beginning all the way until the drug reaches the patient," Schondelmeyer said.But it's not just COVID-19 drugs that are in short supply. Dr. Beth Thielen, an assistant professor of pediatrics at the University of Minnesota Medical School and an infectious disease physician, says even some routine drugs are hard to come by."As a physician working in the hospital — the University of Minnesota — we're a big urban center and yet we're regularly dealing with this issue of shortages in routine things like antibiotics," Thielen said. "It's very concerning to think about the supply chain breaking down and seeing drugs not available in pharmacies or the hospital."Doctors say COVID-19 has unmasked a problem that's been a concern for decades. The pharmaceutical supply chain is complicated and dependent on other countries — and there are supply and demand dilemmas."Start the conversation now with your healthcare provider," Thielen said. "There might be some within class substitutions of medicines, so a drug that is related may not be the exact same drug but might fulfill the same purpose."Schondelmeyer adds that anyone with a regular prescription should ask their doctor about getting a 90-day supply of essential drugs — but adds that there's no reason to hoard medication."We shouldn't panic. We shouldn't treat drugs like we did toilet paper and stock up on so much that we're totally out — and that's an example of what can happen when there's rumors of shortages," Schondelmeyer said. "People act out of fear, and they hoard more than they really need."In the meantime, Schondelmeyer is pushing for a national stockpile of critical medications, so that the U.S. is covered should there be a complete breakdown in the supply chain. 3236

A second Trump Organization employee discussed a potential immunity deal with the federal prosecutors who charged Michael Cohen, President Donald Trump's former personal attorney, according to people familiar with the matter.That employee ultimately did not receive immunity after prosecutors in the US Attorney's Office for the Southern District of New York decided against granting such protection. The person was not called to testify before the grand jury, the people familiar with the matter said.The employee's identity couldn't be determined by CNN. Spokespeople for the US Attorney's office and Trump Organization declined to comment.News of the second employee's talks with prosecutors comes after Trump Organization chief financial officer Allen Weisselberg was granted immunity for providing information about Cohen. Weisselberg's interview with prosecutors focused on Cohen and the payments Cohen made to silence women during the election cycle who claimed affairs with Trump.Prosecutors also granted immunity to David Pecker, a longtime Trump ally and the CEO of tabloid publisher American Media Inc. Pecker told prosecutors that Trump had knowledge of Cohen's payments to women who had alleged sexual encounters with the then-presidential candidate, CNN reported. 1285

A turkey with all the trimmings as friends and family gather around to give thanks – that’s what we look forward to each year for Thanksgiving. But this time around won’t be the same, with COVID-19 at the forefront.With an uptick in COVID-19 cases nationwide, the Center for Disease Control and Prevention has released updated guidelines. It starts with keeping the festivity small. A big event could lead to positive test results.Wear a face coveringThis is especially important if you invite guests over. The mask should cover your mouth, nose and fit snug. It should be worn at all times, except for when eating or drinking.Practice physical distancingIt's important to remember that you don't have to symptoms to spread the virus. Asymptomatic carriers can spread COVID-19, as we've seen in past super spreader events. Staying at least 6 feet apart will reduce your risk.Wash your handsAside from wearing a mask and social distancing, washing hands with soap and water for at least 20 seconds is vital. If you are unable to do so, you should have hand sanitizer with at last 60% alcohol nearby.Have a potluck ThanksgivingBringing your own food and utensils to the feast is another safe option. Not only would it reduce your chances of getting the virus, it also takes the pressure off the host.Plan an outdoor Thanksgiving feastHosting a dinner outside with a small group of people would allow for easy ventilation. If celebrating indoors, make sure to open windows to keep fresh flowing.Finally, there's no doubt that staying home is the safest bet. But if you plan to travel, check restrictions before you go. If you follow these guidelines, the safer you’ll be.This story was originally published by Stacy-Ann Gooden at WPIX. 1740

A mother in Mesa, Arizona is voicing concern after her child's 4th-grade teacher changed words in the Declaration of Independence, and made the students recite the altered version in class.The teacher at Salk Elementary school crossed out the words "man" and substituted it with "human".The mother, Elizabeth Vaillencourt said the teacher's goal may have been to include women as well, but she went too far in altering a historical document.When Vaillencourt took this concern to school officials, she was initially told she had "hurt the teacher's feelings" by posting about it on social media.The school reacted by removing Vaillencourt's child from that teacher's classroom, and placing them under a different teacher.On Wednesday, Vaillencourt said the superintendent's office contacted her to tell her what the teacher did was against school policy.A Mesa Public Schools spokeswoman says they have policies in place when it comes to school ceremonies which includes reciting the Declaration of Independence. 1030

A New Jersey man who died of a brain-eating infection called primary amebic meningoencephalitis was exposed while visiting the BSR Cable Park and Surf Resort in Waco, Texas, during the summer, the Waco-McLennan County Public Health District said Friday.Water samples taken by local, state and federal health officials at the beginning of the month "found evidence of Naegleria fowleri," the amoeba that causes the infection, according to the health district.Fabrizio Stabile, 29, visited the surf resort before developing symptoms in September.A GoFundMe page launched by those close to him said he was mowing his lawn when he developed a severe headache. It hadn't gone away by the following morning, and his symptoms progressed until he was unable to speak coherently or get out of bed. He was rushed to the hospital, where doctors found the amoeba in his spinal fluid. "The worst-case scenario was unfolding in front of our eyes," the site says.The health department concluded, "epidemiologic and environmental assessment indicate that exposure likely occurred at this facility."Although the amoeba itself was not found in water samples from the park, "the presence of fecal indicator organisms, high turbidity, low free chlorine levels, and other ameba that occur along with N. fowleri indicate conditions favorable for N. fowleri growth."The tests were taken from the park's Surf Resort, Royal Flush and Lazy River features. Those areas are to remain closed until "all health and safety issues have been addressed and mitigated appropriately," the health department said, adding that the owner of the park is cooperating and working to develop a "comprehensive water quality management plan to include current regulatory requirements."The BSR Cable Park said on its website that it is installing a state-of-the-art filtration system on the three features to ensure that they are "as clear and clean as humanly possible."However, the park is interpreting the test results another way: "Water tests come back clean," the website proclaimed, adding that "comprehensive test results have now confirmed that the water at BSR Surf Resort meets every standard for safety."BSR also offered its condolences: "On behalf of the entire staff at BSR Surf Resort, our hearts and prayers are with Fab Stabile's family, friends, and the New Jersey surf community. A precious life has been lost, and we are deeply saddened for his loved ones."There have been nine cases of primary amebic meningoencephalitis in Texas since 2005, according to the Waco-McLennan County Public Health District. Centers and Disease Control and Prevention data dating to the 1960s show between zero and eight cases per year nationwide, with five cases in 2016, none last year and no other cases reported this year.The amoeba, Naegleria fowleri, is found in warm bodies of fresh water such as lakes and hot springs. It infects people by entering the nose and making its way to the brain. There, it can cause a brain infection that the CDC calls "rare and devastating," known as primary amebic meningoencephalitis. It is almost always fatal, though a handful of people have survived.Health officials recommend keeping water out of your nose while swimming in warm or untreated freshwater, by either holding your nose, keeping it above water or using a nose clip. 3359

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