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SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

Six-time Super Bowl champion quarterback Tom Brady has reached an agreement to join the Tampa Bay Buccaneers.Brady's move to Tampa has been removed since earlier this week.Both Brady and the Buccaneers confirmed an agreement had been reached. 254

Special counsel Robert Mueller delivered his completed investigation of Russian interference in the 2016 election to Attorney General William Barr, the Justice Department announced Friday.Barr sent a letter to House and Senate judiciary leaders, telling them he remains committed "to as much transparency as possible" and would keep them informed "as to the status of my review."Here's the letter:Dear Chairman Graham, Chairman Nadler, Ranking Member Feinstein, and Ranking Member Collins:I write to notify you pursuant to 28 C.F.R. § 600.9(a)(3) that Special Counsel Robert S. Mueller III has concluded his investigation of Russian interference in the 2016 election and related matters. In addition to this notification, the Special Counsel regulations require that I provide you with "a description and explanation of instances (if any) in which the Attorney General" or acting Attorney General "concluded that a proposed action by a Special Counsel was so inappropriate or unwarranted under established Departmental practices that it should not be pursued." 28 C.F.R. § 600.9(a)(3). There were no such instances during the Special Counsel's investigation.The Special Counsel has submitted to me today a "confidential report explaining the prosecution or declination decisions" he has reached, as required by 28 C.F.R. § 600.8(c). I am reviewing the report and anticipate that I may be in a position to advise you of the Special Counsel's principal conclusions as soon as this weekend.Separately, I intend to consult with Deputy Attorney General Rosenstein and Special Counsel Mueller to determine what other information from the report can be released to Congress and the public consistent with the law, including the Special Counsel regulations, and the Department's long-standing practices and policies. I remain committed to as much transparency as possible, and I will keep you informed as to the status of my review.Finally, the Special Counsel regulations provide that "the Attorney General may determine that public release of" this notification "would be in the public interest." 28 C.F.R. § 600.9(c). I have so determined, and I will disclose this letter to the public after delivering it to you.Sincerely,William P. BarrAttorney General 2261

SAN LUIS OBISPO, Calif. — The president of California Polytechnic State University says the college is looking into a 135

RALEIGH, N.C. (AP) — A female wrestler has made history by winning a state high school wrestling championship in North Carolina. The North Carolina High School Athletic Association said on its website that junior Heaven Fitch of Uwharrie Charter Academy became the first female to win an individual state wrestling championship in the state. Fitch 360

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