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WASHINGTON, May 11 (Xinhua) -- Johns Hopkins University researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.The work, published Wednesday in the journal Science Translational Medicine, suggests that liver cells derived from so- called "induced-pluripotent stem cells (iPSCs)" could one day be used as an alternative to liver transplant in patients with serious liver diseases, bypassing long waiting lists for organs and concerns about immune system rejection of donated tissue."Our findings provide a foundation for producing functional liver cells for patients who suffer liver diseases and are in need of transplantation," says Yoon-Young Jang, assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. "iPSC-derived liver cells not only can be generated in large amounts, but also can be tailored to each patient, preventing immune-rejection problems associated with liver transplants from unmatched donors or embryonic stem cells." A microsopic view shows human embryonic stem cells in various stages of differentiation into liver cells in this photo taken at Stanford University and released by the California Institute for Regenerative Medicine, March 9, 2009iPSCs are made from adult cells that have been genetically reprogrammed to revert to an embryonic stem cell-like state, with the ability to transform into different cell types. Human iPSCs can be generated from various tissues, including skin, blood and liver cells.Although the liver can regenerate in the body, end-stage liver failure caused by diseases like cirrhosis and cancers eventually destroy the liver's regenerative ability, Jang says. Currently, the only option for those patients is to receive a liver organ or liver cell transplant, a supply problem given the severe shortage of donor liver tissue for transplantation. In addition, mature liver cells and adult liver stem cells are difficult to isolate or grow in the laboratory, she says. By contrast, iPSCs can be made from a tiny amount of many kinds of tissue; and the embryonic stem- like iPSCs can grow in laboratory cultures indefinitely.For the study, Jang and colleagues generated human iPSCs from a variety of adult human cells, including liver cells, fibroblasts ( connective tissue cells), bone marrow stem cells and skin cells. They found that though the iPSCs overall were molecularly similar to each other and to embryonic stem cells, they retained a distinct molecular "signature" inherited from the cell of origin.

SAN FRANCISCO, May 4 (Xinhua) -- Intel Corp. on Wednesday announced that it will mass-manufacture chips using new transistors featuring a three-dimensional (3-D) structure, calling it a technical breakthrough in microprocessors.The 3-D transistor, called Tri-Gate, represents a fundamental departure from the two-dimensional planar transistor structure that has powered computers, mobile phones and other modern electronics, Intel said."Intel's scientists and engineers have once again reinvented the transistor, this time utilizing the third dimension," Paul Otellini, Intel's chief executive officer, said in a statement.Intel on Wednesday also demonstrated a 22-nanometer (nm) microprocessor, codenamed "Ivy Bridge," which will be the first high-volume chips to use the new 3-D transistors.Ivy Bridge is scheduled for high-volume production readiness by the end of this year, the company said.According to Intel, the 3-D transistors enable chips to operate at lower voltage with lower leakage compared to previous transistors, providing up to 37 percent performance increase at low voltage versus the company's 32nm planar transistors.The gain means that the new 3-D transistors are ideal for use in small handheld devices, which operate using less energy to " switch" back and forth, Intel noted.

LOS ANGELES, April 1 (Xinhua) -- A NASA Gulfstream-III aircraft equipped with a synthetic aperture radar is scheduled to depart Sunday, April 3 on a nine-day mission to image Hawaii volcanoes, the Jet Propulsion Laboratory (JPL) announced on Friday.The aircraft will fly from the Dryden Aircraft Operations Facility in Palmdale, California to the Big Island of Hawaii to study the Kilauea volcano that recently erupted, said JPL in Pasadena, Los Angeles.The mission will help scientists better understand processes occurring under Earth's surface, JPL said.Developed by JPL, the Uninhabited Aerial Vehicle Synthetic Aperture Radar, or UAVSAR, uses a technique called interferometric synthetic aperture radar that sends pulses of microwave energy from the aircraft to the ground to detect and measure very subtle deformations in Earth's surface, such as those caused by earthquakes, volcanoes, landslides and glacier movements.As the Gulfstream-III flies at an altitude of about 12,500 meters, the radar, located in a pod under the aircraft's belly, will collect data over Kilauea, according to JPL.The UAVSAR's first data acquisitions over this volcanic region took place in January 2010, when the radar flew over the volcano daily for a week. The UAVSAR detected deflation of Kilauea's caldera over one day, part of a series of deflation-inflation events observed at Kilauea as magma is pumped into the volcano's east rift zone.This month's flights will repeat the 2010 flight paths to an accuracy of within 5 meters, or about 16.5 feet, assisted by a Platform Precision Autopilot designed by engineers at NASA's Dryden Flight Research Center on Edwards Air Force Base, California, JPL said.By comparing these camera-like images, interferograms are formed that reveal changes in Earth's surface, said JPL.Between March 5 and 11, 2011, a spectacular fissure eruption occurred along the east rift zone. Satellite radar imagery captured the progression of this volcanic event."The April 2011 UAVSAR flights will capture the March 2011 fissure eruption surface displacements at high resolution and from multiple viewing directions, giving us an improved resolution of the magma injected into the east rift zone that caused the eruption," said JPL research scientist Paul Lundgren."Our goal is to be able to deploy the UAVSAR on short notice to better understand and aid in responding to hazards from Kilauea and other volcanoes in the Pacific region covered by this study," Lundgren added.

BEIJING, Jan. 27 (Xinhua) -- The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities.The pilot reform will tax property owner-occupiers for the first time, officials from the Ministry of Finance, the State Administration of Taxation and the Ministry of Housing and Urban-Rural Development said Thursday.China's 1986 provisional property tax regulations did not tax owner-occupiers.The cities themselves will decide the details of the real estate levy. File photo taken on Apr. 23, 2010 shows residential areas in Shanghai, east China. The State Council, China's cabinet, has approved on a trial basis the launch of property tax reforms in some cities. Shanghai and Chongqing are cities that will trial the tax first. Shanghai sets its property tax rate at 0.4 to 0.6 percent. Municipalities impose property taxes on owners of real estate based upon the value of the property.Shanghai and Chongqing are cities that will trial the tax first.Shanghai set its property tax rate at 0.4 to 0.6 percent. Chongqing sets its at 0.5 to 1.2 percent.