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WEST PALM BEACH, Fla. (AP) — Unemployment benefits for millions of Americans are set to lapse at midnight unless President Donald Trump signs an end-of-year COVID relief and spending bill that had been considered a done deal before his objections. He is demanding larger COVID relief checks for Americans and complaining about "pork" spending. But Congress has already passed the package by large margins in both houses. Failing to sign it will mean pain for those struggling to make ends meet and a potential federal government shutdown in the middle of a global pandemic. 581
With a coronavirus vaccine still months off, companies are rushing to test what may be the next best thing: drugs that deliver antibodies to fight the virus right away, without having to train the immune system to make them.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. Vaccines work by tricking the body into thinking there’s an infection so it makes antibodies and remembers how to do that if the real bug turns up.But it can take a month or two after vaccination or infection for the most effective antibodies to form. The experimental drugs shortcut that process by giving concentrated versions of specific ones that worked best against the coronavirus in lab and animal tests.“A vaccine takes time to work, to force the development of antibodies. But when you give an antibody, you get immediate protection,” said University of North Carolina virologist Dr. Myron Cohen. “If we can generate them in large concentrations, in big vats in an antibody factory ... we can kind of bypass the immune system.”These drugs are believed to last for a month or more and could give quick, temporary immunity to people at high risk of infection, such as health workers and housemates of someone with COVID-19. If they proved effective and if a vaccine doesn’t materialize or protect as hoped, the drugs might eventually be considered for wider use, perhaps for teachers or other groups.They’re also being tested as treatments, to help the immune system and prevent severe symptoms or death.“The hope there is to target people who are in the first week of their illness and that we can treat them with the antibody and prevent them from getting sick,” said Dr. Marshall Lyon, an infectious disease specialist helping to test one such drug at Emory University in Atlanta.Having such a tool “would be a really momentous thing in our fight against COVID,” Cohen said.Vaccines are seen as a key to controlling the virus, which has been confirmed to have infected more than 20 million people worldwide and killed more than 738,000. Several companies are racing to develop vaccines, but the results of the large final tests needed to evaluate them are months away.The antibody drugs are “very promising” and, in contrast, could be available “fairly soon,” said Dr. Janet Woodcock, a U.S. Food and Drug Administration official who is leading government efforts to speed COVID-19 therapies. Key studies are underway and some answers should come by early fall.One company, Eli Lilly, has already started manufacturing its antibody drug, betting that studies now underway will give positive results.“Our goal is to get something out as soon as possible” and to have hundreds of thousands of doses ready by fall, said Lilly’s chief scientific officer, Dr. Daniel Skovronsky.Another company that developed an antibody drug cocktail against Ebola — Regeneron Pharmaceuticals Inc. — now is testing one for coronavirus.“The success with our Ebola program gives us some confidence that we can potentially do this again,” said Christos Kyratsous, a Regeneron microbiologist who helped lead that work.Regeneron’s drug uses two antibodies to enhance chances the drug will work even if the virus evolves to evade action by one.Lilly is testing two different, single-antibody drugs — one with the Canadian company AbCellera and another with a Chinese company, Junshi Biosciences. In July, Junshi said no safety concerns emerged in 40 healthy people who tried it and that larger studies were getting underway.Others working on antibody drugs include Amgen and Adaptive Biotechnologies. The Singapore biotech company Tychan Pte Ltd. also is testing an antibody drug and has similar products in development for Zika virus and yellow fever.“I’m cautiously optimistic” about the drugs, said the nation’s top infectious diseases expert, Dr. Anthony Fauci. “I’m heartened by the experience that we had with Ebola,” where the drugs proved effective.What could go wrong?— The antibodies may not reach all of the places in the body where they need to act, such as deep in the lungs. All the antibody drugs are given through an IV and must make their way through the bloodstream to wherever they’re needed.— The virus might mutate to avoid the antibody — the reason Regeneron is testing a two-antibody combo that binds to the virus in different places to help prevent its escape.Skovronsky said Lilly stuck with one antibody because manufacturing capacity would essentially be cut in half to make two, and “you will have less doses available.” If a single antibody works, “we can treat twice as many people,” he said.— The antibodies might not last long enough. If they fade within a month, it’s still OK for treatment since COVID-19 illness usually resolves in that time. But for prevention, it may not be practical to give infusions more often than every month or two.A San Francisco company, Vir Biotechnology Inc., says it has engineered antibodies to last longer than they usually do to avoid this problem. GlaxoSmithKline has invested 0 million in Vir to test them.Giving a higher dose also may help. If half of antibodies disappear after a month, “if you give twice as much, you will have two months’ protection,” Lilly’s Skovronsky said.— The big fear: Antibodies may do the opposite of what’s hoped and actually enhance the virus’s ability to get into cells or stimulate the immune system in a way that makes people sicker. It’s a theoretical concern that hasn’t been seen in testing so far, but large, definitive experiments are needed to prove safety.“As best as we can tell, the antibodies are helpful,” Lyon said.___Marilynn Marchione can be followed on Twitter: @MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 5919
WILMINGTON, Del. (AP) — Democratic presidential candidate Joe Biden is confirming that he’s been tested at least once for the COVID-19 virus and promises he will be tested regularly during his campaign against President Donald Trump. Biden told reporters Friday of his testing protocol during a wide-ranging news conference he used to blast Trump for downplaying the virus and thus ensuring that it will continue to kill Americans and ravage the economy. For much of the summer, Biden’s advisers deflected questions about whether the former vice president was being tested himself as he anchored his campaign almost exclusively from his Delaware home, traveling sparingly as a precaution.Biden plans on resuming a relatively normal travel schedule after Labor Day. Since March, Biden has mostly held virtual events due to the coronavirus. 847
WILMINGTON, Del. – Sen. Kamala Harris of California will be Joe Biden’s running mate in the 2020 presidential election.The presumptive Democratic nominee announced Tuesday that Harris will join him on the ticket. If she and Biden win in November, she would become the first woman and African-American elected as vice president.Biden’s selection comes after weeks of vetting several candidates for the role, all of which were women because the former vice president vowed to run alongside a female prospect.The Biden campaign said Harris and Biden will deliver remarks from Delaware on Wednesday.Tweeting from her official account, Harris said, "Joe Biden can unify the American people because he's spent his life fighting for us. And as president, he'll build an America that lives up to our ideals. I'm honored to join him as our party's nominee for Vice President, and do what it takes to make him our Commander-in-Chief."Harris is a U.S. senator and African American leader from California. She also made a name for herself as a presidential candidate, running against Biden himself during this election. Some Biden advisers don't like how she attacked Biden during the campaign, not to mention her time as a prosecutor could hurt her with some voters.Biden officially clinched the party’s nomination in June, when he reached the 1,991 pledged delegates needed.Biden is expected to accept the nomination during the Democratic National Convention, which will be held virtually next week due to COVID-19 concerns. It was originally set to be held in Milwaukee. Harris will also speak during the event, along with other top Democrats.This story is breaking and will be updated. 1685
While most performers have had to shelve public performances during the coronavirus, musician Trey Songz performed at a nightclub in Columbus, Ohio, on Saturday.According to Trey Songz’s social media accounts, he performed at the Aftermath Nightclub on Saturday.While in normal times, the concert wouldn’t be newsworthy, the performance prompted Columbus City Attorney Zach Klein to order the nightclub temporarily closed, claiming the concert violated state COVID-19 requirements. He issued a restraining order against the club on Tuesday. Klein says the order will be effective until the case goes before a court, which he says could come on December 17.Ohio currently requires people in public indoor spaces to wear masks unless they’re actively eating or drinking. Klein said that the nightclub disregarded the mandate, based on an investigation by the Ohio Investigative Unit. His office estimates that 500 people were attendance at the concert.“Last weekend’s indoor concert at Aftermath was in blatant disregard of COVID-19 health orders and social distancing best practices,” said Klein. “We are in the middle of a surge in coronavirus infections, yet the owners of Aftermath planned to continue hosting large-scale events at their venue, including this upcoming weekend. In the interest of community health, we secured an immediate shutdown of this property.”Videos shared on Instagram from attendees of the performance showed hundreds of people congregated around the stage standing shoulder to shoulder, with few people wearing masks.In October, Songz posted on Instagram that he had tested positive for the virus. "I will be taking it seriously," Songz said. "I've always taken it serious. If you come in contact with COVID, please do the same. Please do the same."Ohio set its one-day record for coronavirus cases with more than 25,000 reported on Tuesday, but officials said that 13,000 of those cases were due to a backlog in reporting. 1959