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Stocks, already rattled by the US-China trade war, were set to fall sharply Friday after President Donald Trump announced new tariffs on Mexican imports.Dow 169

Scientists have discovered a "monster black hole" so massive that, in theory, it shouldn't exist.It's a stellar black hole — the type that forms after stars die, collapse, and explode. Researchers had previously believed that the size limit was no more than 20 times the mass of our sun because as these stars die, they lose most of their mass through explosions that expel matter and gas swept away by stellar winds.This theory has now been toppled by LB-1, the newly-discovered black hole. Located about 15,000 light years away, it has a mass 70 times greater than our sun, according to 601

Schools in the greater Denver area will be closed Wednesday as authorities search for a woman whom they described as armed and "infatuated" with the Columbine mass shooting days before the 20th anniversary of the attack.Local, state and federal officials are searching for Sol Pais, 18. She made "credible" -- but unspecific -- threats after traveling from Miami to Denver on Monday night, and is considered dangerous, said Dean Phillips, the special agent in charge of the local FBI office.After she arrived, she immediately went to a store and bought a pump action shotgun and ammunition, the FBI said Tuesday night.Pais is considered a threat to the community and schools, but there is no information on any specific threat to a particular location, Phillips said.Nearly 20 school districts will be closedNearly 20 school districts in the greater Denver area will be closed Wednesday due to security concerns just days ahead of the 20th anniversary of the Columbine High School shooting.They include the Douglas County School District , Aurora Public Schools, Jefferson County Public Schools and Cherry Creek Schools. Columbine High School is in Jefferson County."There are many people that work diligently day in and day out ... that are making the very best decisions they can for the sake of the kids who are in schools each and every day," said Jefferson County Sheriff Jeff Shrader. "We want our schools to be a safe place for kids to learn."The Colorado Department of Education recommended that Denver area schools conduct lockouts and controlled release Tuesday after the alleged threats.In a lockout, exterior doors are locked, and school continues as normal.Columbine High and several schools in the area were part of the lockout, the Jefferson County Sheriff's Office tweeted.She was last seen wearing camouflage pantsAfter Pais arrived in the state Monday and purchased a pump action shotgun and ammunition, she went to the foothills, where she was last seen, Phillips said."Her comments, her actions that we have heard about from others tend to cause us great concern that she may pose a threat to a school," he added.Officials released an image of Pais. She is about 5-foot-5 and was last seen wearing a black T-shirt, camouflage pants and black boots, authorities said.Authorities said they are being especially cautious because Pais' statements don't express a specific plan and were mostly spoken."She did make statements that were threatening to schools and she did purchase a firearm ... and that's why she's a credible threat," said Patricia Billinger, a spokeswoman with the Colorado Department of Public Safety.Anniversary of Columbine shooting is this weekThe 20th anniversary of the shooting at Columbine High School is days away.On April 20, 1999, two students killed 12 of their schoolmates and one teacher in a mass shooting at the high school in the town of Littleton -- about 10 miles from Denver."I know that this opens a wound, especially on an anniversary week, for those families who were most deeply impacted by this," Shrader said.At this point, there might not be enough probable cause to arrest Pais, but the federal and state attorneys' offices are working to develop appropriate charges, Phillips said. He said once they detain her, they will hold her for as long as they legally can.Authorities are asking for the public's help finding her, and tips can be sent to the tip line at (303) 630-6227 or emailed to denverfbitips@fbi.gov. 3486

SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

Searchers have found a third body buried by an avalanche at an Idaho ski resort, and they confirmed it is a person who was reported missing on Wednesday. Tuesday's avalanche at the Silver Mountain Resort killed two other people and injured four. Searchers in a helicopter spotted the missing person's body on Thursday. Meanwhile, the Shoshone County Sheriff's Office has identified two of the dead as 58-year-old Carl Humphreys of Liberty Lake, Washington, and 46-year-old Scott Parsons of Spokane Valley, Washington. Avalanche survivor Bill Fuzak says he knew there was nothing he could do but wait and pray. 622

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