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LA JOLLA (KGTV): Researchers at the UC San Diego Moores Cancer Center and the La Jolla Institute of Allergy and Immunology have teamed up to find a new way to fight cancer.They've created a vaccine that can help teach the immune system how to attack only cancer cells and leave the rest of the body alone."Patients will be able to tolerate their therapy much better than they have so far on conventional approaches," says Dr. Stephen Schoenberger from the La Jolla Institute.Each vaccine is highly personalized to the patient. According to a release from UC San Diego, the vaccines "defines the neoantigens – foreign protein fragments recognized by the immune system – in a patient’s cancer. With neoantigens identified, the team can identify peptides – strings of amino acids – that can be used to create a vaccine to stimulate a protective immune system response."Simply put, the new vaccine takes information from a patient's immune system and the tumor and uses it to help white blood cells to fight it."We're giving them life and giving them hope," says Dr. Schoenberger.The first patient in the clinical trial is Tamara Strauss. She was diagnosed with pancreatic cancer in 2015 and went through chemotherapy and surgery."It was brutal," says Strauss. "It's been three and a half years of hell."Strauss' parents helped fund the clinical trial with a million donation. She says she feels fortunate they could do that, but also hopeful that it helps others down the road."I really pray that this vaccine and personalized form of treatment really does change the paradigm of cancer treatment," says Strauss.During the trial, ten patients will get three doses of the vaccine. They'll also be on Keytruda, an immune system boosting drug for up to two years. Their health will be monitored for five years to determine the vaccine's effectiveness. 1871

JULIAN, Calif. (KGTV)-- This was the first weekend San Diegans were able to enjoy the snow-packed mountains. But morning road closures made traveling uphill from San Diego difficult. By early afternoon, most road restrictions were lifted, and thousands of people made their way to the tourist towns. To Teak Nichols, Julian is just home. But he knows it is a special place. "It's been really magical the last few days. So I can understand why people would want to be a part of that," Nichols said. With its old-world charm and snow-packed roofs, Julian is an escape from the daily grind. "We wanted to get away from the city," San Diegan Sandra Aguiar said. She brought her husband's family from Tijuana to experience the allure of the small town. But she said it was not an easy ride. "It took about an hour and 45 minutes," Aguiar said. "Then two miles from here, it was bumper to bumper."Until 1 p.m. Saturday, California Highway Patrol officers slowed down drivers to enforce chain controls along State Route 79 at Cuyamaca Rancho State Park. Many parts of Sunrise Highway were also shut down due to icy conditions. "In some parts, it was kind of scary. We were sliding a little bit," Aguiar said. Even after they finally made it into town, the waiting continued. Aguilar's main reason for coming up the hill was to get a bite of Nichol's mother's famous dessert at Mom's Pies. "I've tried Julian pies before, but these are the best," Aguiar said. Nichols said it is a recipe that has been kept a secret since 1984. It is a seasonal favorite that sells out, every time it snows."It's gotten busier as the day has gone on," Nichols said. "Apparently, the road opened up, so we got a little bit busier after that."Snow days may slow down traffic and clog up parking, but customers said it is all worthwhile."It's homemade, and it makes it better because we're with family," Aguiar said. "The ice cream was also delicious with it. I mean, it's well worth it!"By mid-afternoon, CHP opened up SR-79 with no restrictions. 2028

KANSAS CITY, Mo. — For the Guidino family, the work at their mechanic shop is nonstop.Deyanira Gudino's father works to fix engines, mirrors, replace tires, and other parts to make sure it's the right fit for customers' cars.But there was something bigger in their lives stalling."It's something we've been waiting for for years and it's something we wanted ever since we arrived in the United States," Deyanira Gudino said.At nearly two years old, Deyanira and her parents moved from Mexico City to Kansas City."I’ve always said I love my country (Mexico) but thanks to God, this country has given me the opportunity to give my children a place and give them a chance to go to school," Deyanira Gudino's mother, Azucena Cruz said. "Something we couldn’t do in our country.”The transition wasn't easy and oftentimes scary.“It’s very difficult because when she (Deya) arrived here, she was going to turn two years old and when I had to work, I had to leave her," Cruz said. "I remember I enrolled her in an army nursery where she could stay all day."Deyanira said the hardest part was feeling safe. Her parents would stay in much of the time unless it was a necessity to go out."We would go wherever we needed to go but we would never travel the U.S.," she said. "We would never do any of that exploring stuff because they were always in fear that something could go wrong."The language was also a barrier."We had no clue how to communicate with anyone here. And it was very difficult for me to learn once I started school because at home, all we spoke was Spanish," Deyanira said. "The little bit of English I knew, I had to help my parents translate, even just going to the store, finding something, anything that my parents had to speak English for. I had to use my little bit of language that I knew to translate for them. So it was really difficult for all of us, but eventually, I started learning a lot more English. And they got used to being here, so they adapted to the language a little so they started understanding the basic words in English."For roughly 10 years, they've been working on becoming permanent residents, and recently Deyanira received the phone call they'd been waiting for."We were just so happy and full of emotions whenever we received the call saying that we were residents," she said.But it wasn't her parents who heard the news first."I was the one that actually got the call and I just wanted to find a nice way to surprise them," she said.And she did. She and her younger sister, Carmen, had gifts waiting for their parents, recording their reaction when they found out they were now residents of the United States:"It was really exciting for all of us and I was just full of emotions," Deyanira said."We were at a party and my daughter was reading me the comments," Cruz said. "I cried all day, knowing that so many people were sending us blessings, that they wished us the best.”For Deyanira, it's a moment of resiliency and perseverance."I really fought for everything that I have now, so I know now that I have my residency nothing else is really going to stop me," she said.And it's not just for her, but her parents."They sacrifice so much leaving their country to give me a better future," Deyanira said. "I definitely have done everything I have done for them because I know that it's all they wanted to see me succeed."And that's still the case.“Well very emotional, happy, more than anything for my family. Well because it’s 20 years that we can’t see our family. That my daughter (Deya) more than anything didn’t have the opportunities that citizens have, that people who with documentation have," Cruz said.The biggest message they have for others? Keep going."Don’t give up. It is possible for things to be done if someone comes to country and they come to do them right," Cruz said."Don't stop fighting," Deyanira said. "Just keep believing things will get better, 'cause things will get better."Deyanira's sister shared the reaction video on TikTok and it had more than 1.1 million views. Several comments flowed in for the Gudino family congratulating them and sharing their excitement.This story was first reported by Rae Daniel at KSHB in Kansas City, Missouri. 4222

JACKSONVILLE, Fla. (AP) — A founder of the Salt Life clothing brand is facing a manslaughter charge in the death of an 18-year-old woman at a Florida hotel.Michael Troy Hutto was being held without bond Sunday at the Duval County jail in Jacksonville following his arrest in connection with the death of 18-year-old Lora Grace Duncan.Her body was found Thursday at a Palm Beach County hotel. Police say she had been fatally shot.Hutto was arrested Friday. Investigators have not said how they believe Hutto is connected to Duncan’s death or if they had a relationship.Jail records do not show if Hutto has an attorney.Hutto no longer owns Salt Life. He sold the business in 2013. 687

Katy Perry has given birth to a baby girl named Daisy Dove Bloom.In a post on Instagram, a black and white photo of two adult hands grasping a baby’s hand announce the birth. Perry is engaged to Orlando Bloom.“We are floating with love and wonder from the safe and healthy arrival of our daughter,” the couple says. 323