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Tibbetts, a sophomore, was studying psychology and wanted to earn a doctorate and write books, her father said."It's intolerable. No one just disappears, no one just vanishes without a trace," he told HLN.On the day she vanished, Tibbetts' brother dropped her off at her boyfriend's house so she could dog-sit, HLN reported. She was last spotted jogging around 7:30 that evening, wearing gym shorts, a black sports bra and running shoes, the sheriff's office said.Calderwood said the recent weeks have felt like torture."The first night she went missing, I was distraught," Calderwood told CNN affiliate KCCI in Des Moines. "I knew her phone was dead, but I sent her a text saying, 'I love you. We're looking for you. We will find you no matter what.'" 752

There has been an active shooter situation at Dennis Intermediate School. At this time, the school building is secure.— WeRrichmond (@wearrrichmond) December 13, 2018 166

This fencing, however, was initially requested during President Obama’s time in office, but the project did not start until last year. 134

This is really a law for people who are very sick, who have exhausted all treatment options and who cannot enroll in a clinical trial, said Starlee Coleman, senior policy adviser at the Goldwater Institute, a conservative public policy think tank based in Phoenix that supports right-to-try legislation."For people living in a state where right-to-try is already on the books, they already have the ability today to work with their doctors directly to approach a drug company with a drug in clinical trials and ask for the option to try that drug outside of the clinical trial," she said. "For people living in the 12 states without a right-to-try law, today they don't have this option, but if the federal law passes, they will have the option."Some opponents argue that the bill won't change much but could have a detrimental effect on how the FDA safeguards the health of the public.Dr. Steven Joffe, professor in medical ethics and health policy at the University of Pennsylvania's Perelman School of Medicine, co-authored a perspective paper about such concerns, published in the New England Journal of Medicine last month.The paper notes that the FDA already has expanded-access policies, sometimes called compassionate use, to give terminally ill patients without other options access to investigational medical products outside of clinical trials.About 99% of submitted applications for expanded access to almost 9,000 investigational drugs were allowed to proceed over a 10-year period between January 2005 and December 2014, according to a study by FDA researchers, published in the journal Therapeutic Innovation & Regulatory Science in 2016."Emergency requests for individual patients are usually granted immediately over the phone and non-emergency requests are generally processed within a few days," FDA Commissioner Dr. Scott Gottlieb said in a statement last year. 1885

Tolkienists start at the verdant Hobbiton Movie Set on a 1,250-acre sheep farm about two hours from Auckland. Enter one of the 44 hobbit-holes and explore Bag End, and don't forget to visit the reconstructed oak with its synthetic leaves. Then have a ginger beer at the Green Dragon Inn, where Bilbo Baggins met Gandalf and the Dwarves. Guides explain where Ringer scenes took place and which sets were redeveloped and made permanent for Hobbits. 446