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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.
BEIJING, Feb. 18 (Xinhua) -- Jia Qinglin, China's top political advisor, urged the municipality of Beijing to intensify efforts to promote the development of service and manufacturing industries.Jia, chairman of the National Committee of the Chinese People's Political Consultative Conference, made the remarks during his inspection tour in Beijing from Wednesday to Friday.During the tour, Jia visited factories, construction sites and communities to exchange views with officials and civilians. He also listened to a report from the Beijing municipal government.Beijing has taken the lead in optimizing its industrial structure as the output of its service industry accounts for 75 percent of the revenue from all sectors, according to official sources of the city.Jia encouraged Beijing to continue to promote its service sector by focusing on producer services and expanding the city's service businesses overseas.While visiting Beijing Benz Automotive Co., Ltd., Jia called for the strengthening of technological innovation in order to boost high-end equipment manufacturing.Beijing should turn itself into a center for national technological innovation to contribute to the country's economic development, Jia said.He also stressed the better protection of forest resources and the more efficient use of water to develop modern agriculture.
BAIKONUR, Kazakhstan, April 5 (Xinhua) -- Russian manned spacecraft Soyuz TMA-21 has been transported to the launch pad and raised to a vertical position, ready to blast off on April 5, Xinhua correspondents reported Saturday from the site.The launch is dedicated to the 50th anniversary of the first flight into space in 1961 carried out by Russian cosmonaut Yuri Gagarin.For hours, journalists and tourists from all over the world had braved a nasty weather and watched the train and trucks delivering the rocket to the pad.Service towers move towards the Soyuz TMA-21 spacecraft, named after the first cosmonaut Yuri Gagarin, as it is set on its launch pad at Baikonur cosmodrome April 2, 2011. The International Space Station (ISS) crew of U.S. astronaut Ronald Garan and crew mates Russian cosmonauts Alexandr Samokutyaev and Andrey Borisenko is due to travel by Soyuz spacecraft to the ISS on April 5.The Soyuz TMA-21 rocket will deliver three crew members to the International Space Station (ISS) on April 5. In a six-month mission, these cosmonauts will carry out over 40 experiments.The Soyuz TMA modification is a replacement of the Soyuz TM as it was equipped with smaller and more efficient computers and improved displays. The Soyuz TMA-21 will also serve as the return vehicle of the ISS crew.
SHANGHAI, Feb. 19 (Xinhua) -- Shanghai and several other Chinese cities have moved to restrict home purchases in a bid to deflate bubbles in the real estate market.The rules, which were revealed by Shanghai's Housing Guarantee and Administration Bureau on Saturday, prohibits new home purchases from locally-registered families who have owned two or more homes and non-local registered families who have owned at least one home.Additionally, non-Shanghai registered families who have no documents certifying they have paid for social security or income tax in the city for one year are banned from buying property.Sales of commercial homes fell 42.4 percent year on year in Shanghai in 2010 as earlier measures to curb the speculative demand in the real estate market took effect.Despite the fall in sales volume, the average price of new commercial homes rose by 7.6 percent to 20,995 yuan (3,200 U.S. dollars) per square meter last year.On the same day, authorities in the eastern city of Nanjing and the northeastern city of Harbin rolled out similar purchase restrictions.On Wednesday, the Beijing municipal government unveiled even tougher measures to prohibit home purchases from non-local registered families who have no proof of social security or income tax payments in the Chinese capital for five straight years.The purchase limits came after the State Council, China's Cabinet, ordered late last month that cities where home prices are skyrocketing must implement strict measures to restrict home purchases over a period of time.The State Council also said that local governments will be responsible for the stable and healthy growth of property markets and are required to publicize, before the end of March, the annual "controlled" price targets for new homes.China has implemented a series of measures since last year, which includes higher down payment and lending rates, and bans on mortgage loans for third homes, to rein in the rapid rise in housing prices.Soaring prices have become a major concern for urban Chinese residents as more homes turn unaffordable. In fact, home prices in some major cities such as Beijing have more than doubled over the past two years.
VIENNA, March 28 (Xinhua) -- Stress hormone is helpful in alleviating acrophobia, a morbid fear of great heights, according to a study by Austrian scientists.They published the findings in the recent Proceedings of the National Academy of Sciences of the United States of America.Frank H. Wilhelm, professor from the Department of Clinical Psychology, Psychotherapy and Health Psychology at the University of Salzburg, Austria, carried out the first study demonstrating the clinical effectiveness of hormones released at periods of high stress in anxiety.The study found hormones and other drugs could be a good addition to behavioral treatment of several anxiety disorders.People with acrophobia have formed a so-called fear memory, which could be activated when the fear-causing stimulus occurs. They tend to react with feelings of extreme fear and anxiety to the ride in a glass elevator.Hence, scientists conducted a confrontation therapy, trying to mask this memory.A total of 40 experimental subjects had been put in a safe environment to constantly confront the fear-inducing stimulus, until they had a new reaction to the perceived threat.Observations also suggested hormones released in high stress had impact on learning and memory.Additionally, stress hormones were believed to facilitate the storage of new, anxiety-free competence and experienced confidence in the therapy. Animal studies have shown that this emotional relearning benefits from cortisol, one of the stress hormones.