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BUFFALO, N.Y. — When a man's car was damaged in an alleged hit-and-run accident, it was a note from a sixth grader who helped him find who was responsible.According to Andrew Sipowicz, he received an anonymous note on his car from a student at Houghton Academy explaining that she had been aboard a bus that had damaged his car in an accident. The bus driver then fled the scene.Sipowicz shared the note alongside two pictures on his Twitter feed with the caption: "Shoutout to the anonymous 6th grader for saving me a couple thousand (Bus not drawn to scale)."As of early Wednesday afternoon, Sipowicz's tweet has been liked more than half a million times and retweeted more than 100,000 times.He later noted on Twitter that he had found the girl who wrote the letter and was "in the process of finding a way to reward her for her actions." 869

Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CDC Director Robert Redfield gave a dire warning of a “rough” winter ahead as hospitals fill with coronavirus patients across the United States, he said in a discussion with the U.S. Chamber of Commerce Foundation on Wednesday.According to data compiled by the COVID Tracking Project, COVID-19 hospitalizations nearly reached 100,000 on Tuesday, a point much higher than the spring and summer surges of the virus. There were nearly 2,500 coronavirus-related deaths throughout the US reported on Tuesday, marking levels not seen since the spring.And with millions of Americans returning from holiday gatherings last week, the level of illnesses could increase in the coming weeks."December and January and February are gonna be rough times. I actually believe they're gonna be the most difficult time in the public health history of this nation,” Redfield said.As of Tuesday afternoon, there have been 272,000 coronavirus-related deaths in the US since March. Redfield said his expectation is that the total could reach 450,000 in the next two months, which would place the average number of deaths per day between now and then at 3,000.Despite the tremendous toll the virus has taken on humanity, Redfield also recognized there is an economic loss associated with the virus.“Probably one of our greatest casualties of the pandemic this year was the impact on the business community, and on just general health care, the impact on our children’s education,” Redfield said.But as virus cases are surging, public health experts say there is light at the end of the tunnel. The federal government expects to have 40 million vaccines prepared for shipment by the end of the month.Moncef Slaoui, the chief adviser for Operation Warp Speed, said the goal is to have nearly the entire at-risk population of the US vaccinated by the end of Feburary.'We will have potentially immunized 100 million people, which is really more or less the size of the significant at-risk population,” Slaoui said. 1994

California will end the cash bail system in a sweeping reform for the state. Rather than requiring defendants to pay in order to be released before trial, their release will hinge on an assessment of their risk to public safety."Today, California reforms its bail system so that rich and poor alike are treated fairly," Gov. Jerry Brown said in a statement.Brown signed the bill Tuesday, and the new law goes into effect October 1, 2019.Critics have long contended that the money bail system perpetuates inequality. While some people are able to quickly get out of jail by posting bail, people who aren't able to afford it sit in jail until the court takes action, or until they work with a bail bond agent to secure their freedom, which can leave them in debt."Abolishing money bail and replacing it with a risk-based system will enhance justice and safety. For too long, our system has allowed the wealthy to purchase their freedom regardless of their risk, while the poor who pose no danger languish in jail," said Assemblymember Rob Bonta, one the lawmakers who introduced the bill, in a statement.Under the new law, a pretrial assessment would be done by either court employees or a local public agency that has been contracted to determine a defendant's risk. That entity would assess the likelihood that the person will not appear in court or commit a new crime while released, and would make a recommendation for conditions of release. The pretrial assessment services will not release a person arrested for violent felonies.The California Money Bail Reform Act, also known as Senate Bill 10, passed in the State Senate with a vote of 26-12, and the General Assembly by 42-31."SB 10 puts all Californians on equal footing before the law and makes public safety the only consideration in pretrial detention. This critical reform is long overdue," Toni Atkins, Senate president pro tempore, said in a statement.But the ACLU in California expressed disappointment over the bill, saying it "is not the model for pretrial justice and racial equity that California should strive for.""It cannot guarantee a substantial reduction in the number of Californians detained while awaiting trial, nor does it sufficiently address racial bias in pretrial decision making," said the three executive directors of the California ACLU affiliates, Abdi Soltani (Northern California), Hector Villagra (Southern California) and Norma Chávez Peterson (San Diego & Imperial Counties). "Indeed, key provisions of the new law create significant new risks and problems."The organization pulled its support for the bill earlier this month as the it underwent changes in the state legislature. 2705

CARLSBAD, Calif. (KGTV) – Legoland California officials say the Carlsbad theme park will not reopen to the public before Aug. 1.In a statement, officials said: “Considering the constantly changing Coronavirus situation and the recent announcement by the San Diego County Board of Supervisors, LEGOLAND? California will not reopen prior to August 1, 2020. The Board announced there will be no reopenings approved prior to that date.”Officials also said a reopening date for the Legoland Hotel will be announced soon.Despite the park’s closure, the Sea Life aquarium is open for guests under state and county guidelines for aquariums.When Legoland California reopens, officials said it will be at reduced attendance and temperature checks for employees. A face covering requirement for all will also be in place.The theme park was closed in March as part of California’s response to the COVID-19 pandemic. 911