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LOS ANGELES, July 18 (Xinhua) -- At least 70 genetic mutations may be involved in the formation of colon cancer, far more than scientists previously thought, a new study suggests.The study by researchers at University of Texas (UT) Southwestern Medical Center contradicts previous thinking that only a few mutated genes may play a role in the development of colon cancer."The ways we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, vice chairman and professor of cell biology at UT Southwestern.The new study identified 65 candidate genes and at least five passenger genes whose mutations play significant roles in cancer development. Inactivating the function of any of these tumor- suppressing genes led to a key step in cancer development called anchorage-independent growth, meaning cells piled up on top of each other rather than aligning neatly.According to previous studies, there were 151 candidate genes and that mutations in just eight to 15 of them would lead to cancer. There were 700 other genes classified as passenger genes whose mutations were incidental to cancer growth.Current cancer treatments target just one or two known cancer- driver genes. While patients may get transient tumor burden reduction, almost universally tumor growth returns."Those numbers are dead wrong," Dr. Shay said, suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.The next step is further research to classify more accurately which genes drive cancer and which are merely passengers, the researchers said.Study findings were published in the July 2011 Cancer Research (Priority Reports).

ISLAMABAD, Sept. 11 (Xinhua) -- Chinese ambassador to Pakistan declared on Sunday that the Chinese government will provide an emergency humanitarian aid worth 30 million RMB (4.7 million U.S. dollars) to Pakistan to help its relief efforts.In light of the immense damages caused by the floods in some parts of Pakistan, Chinese Ambassador to Pakistan Liu Jian called on Pakistani Foreign Minister Hina Rabbani Khar on Sunday to express sympathy and solidarity of the Chinese people toward Pakistani people and declared that the Chinese government will provide the emergency humanitarian aid.Diplomats and staff of the Chinese Embassy in Islamabad have recently voluntarily donated 600,000 rupee (about 6860 U.S. dollars) to the people who hit by the floods. The Chinese ambassador handed over the donation to Pakistani side on Sept. 8.On Sept. 9, Chinese Foreign Minister Yang Jiechi sent a message to his Pakistani counterpart H.E. Hina Rabbani Khar, expressing his profound condolence to the victims and sincere sympathy to the affected people of the floods.The Chinese foreign minister said that China, as Pakistan's close friend, feels as much pain as Pakistan does and is ready to provide help to the best of its ability, in line with Pakistan's needs. He is convinced that the Pakistani people will definitely prevail over the natural disaster and rebuild their homes at an early date.

WASHINGTON, July 7 (Xinhua) -- Space shuttle Atlantis will soar into the sky Friday on NASA's 135th and final flight. Its scheduled return to Earth later this month will mark the end of NASA's 30-year space program.Since its onset with the launch of space shuttle Columbia, the program has been seen as a cheap, safe and reliable way for space exploration.Despite its great contributions to U.S. manned space flight, it has also left some grave and tragic lessons, making its termination inevitable.HIKING COSTSLaunched in 1972 by then President Richard Nixon, the shuttle program aimed to provide a new system of affordable space travel and proved to be NASA's most enduring project in its 50 years of existence.In 1981, shuttle Columbia made its first shuttle flight for two days. It was the ultimate hybrid and the first reusable spacecraft.Launched like a rocket and gliding back to Earth like an airplane, space shuttles not only can act as a space taxi to carry astronauts, but have the muscle of a long-distance trucker to haul heavy machinery.The spaceship boasts more than 3,500 subsystems and 2.5 million parts and is nine times faster than a speeding bullet as it climbs heavenward. That versatility, however, has translated into higher costs.NASA originally estimated the program would cost about 90 billion U.S. dollars. However, its actual cost stands at about 200 billion dollars, compared with the 151 billion dollars spent on Apollo which took Americans to the moon in 1969.In an article in Technology Review, John Logsdon, former head of the Space Policy Institute at George Washington University, drew a direct connection between the ravenous shuttle budget and the lack of other large advances in manned space flight."By operating the system for 30 years, with its high costs and high risk, rather than replacing it with a less expensive, less risky second-generation system, NASA compounded the original mistake of developing the most ambitious version of the vehicle," he wrote."The shuttle's cost has been an obstacle to NASA starting other major projects," he added.HIGH RISKIn terms of safety, the shuttles have never been as reliable as their designers had envisioned.On average, one out of every 67 flights ended up with fatal accidents. Based on the rate of deaths per million miles traveled, the space shuttle is 138 times riskier than a passenger jet.Seven astronauts onboard died when Challenger exploded about a minute after launch in 1986. Nearly two decades after the tragic blast, a new catastrophe descended when the shuttle Columbia disintegrated moments before landing in 2003, killing another seven spacemen.Again, the shuttle program was shelved for more than two years as NASA stepped up efforts to make it safer. But experts say the fundamental problem related to shuttles' safety cannot be solved due to their "birth defects.""It is in the nation's interest to replace the Shuttle as soon as possible," concluded the panel that investigated the 2003 Columbia accident.

WELLINGTON, Aug. 8 (Xinhua) -- A New Zealand study has found that people who work at least 50 hours a week can be up to three times more at risk of alcohol problems than people who work fewer hours.The study, conducted by the University of Otago, used data that followed more than 1,000 people born in Christchurch in 1977 through to age 30.Study leader Dr Sheree Gibb said it aimed to examine whether working hours were related to alcohol problems in early adulthood.Data from more than 1,000 participants at ages 25 and 30 showed a significant association between longer working hours and alcohol- related problems.Longer working hours were associated with higher levels of alcohol problems including frequent alcohol use and alcohol abuse or dependence.People who worked 50 hours or more on average a week were 1.8 to 3.3 times more likely to have alcohol-related problems than those who were not working, and about 1.2 to 1.5 times more likely to have alcohol-related problems than those who worked 30 to 49 hours a week.The higher risk of alcohol abuse for those who worked longer hours was evident in both men and women, according to the study.Gibb said the finding could suggest a need for consideration of policies and programs targeting individuals who worked long hours, with the aim of reducing rates of alcohol-related problems.The article had been accepted for publication by the UK-based journal Addiction.