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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A man in Oklahoma City, Oklahoma has died after being shot by police, though neighbors were yelling that he was deaf.Magdiel Sanchez, 35, was carrying a metal pipe and 15 feet away from police when shots were fired. One witness said officers yelled at him to drop what he was carrying before shooting, but he did not comply. Another said Sanchez often carried the pipe because of stray dogs in the area that would attack.Police said officers on the scene did not hear the neighbors.The officer who shot Sanchez is a police sergeant and is now on leave. The incident is under investigation. 612

A Flint woman was accused of placing her infant children inside a suitcase and leaving them at the curb.On Wednesday, Flint Police responded to a residence in the 500 block of West Pierson Road to assist Child Protective Services.When officers were on scene, a 26-year-old woman placed items to the curb "as if it were trash" and fled from the residence at West Pierson Road on foot, according to a release from Flint police.Police say she was detained after a brief foot chase. Officers returned to the residence and found the woman's two sons, but two children were missing. After searching the area, officers located two 11-month-old twin girls inside a suitcase at the curbside. They were transported to the hospital where they were listed in good condition.The woman remains in custody. 804

A major crackdown could be coming to stop those annoying robocalls. New research from YouMail--a company that developed robocall blocking software--shows each person on the country receives about 150 robocalls a year.Alex Quilici, CEO of YouMail, says these terribly annoying calls keep increasing for two reasons. "One is there are more and more scam calls. The second thing that's driving the increase is people aren't answering the phone anymore," Quilici says.Because people don’t answer their phones, it makes the robocallers place more calls, he says.It’s a problem both Democrats and Republicans can agree on.  Senators John Thune, R-South Dakota, and Ed Markey, D-Massachusetts, have proposed bipartisan legislation to increase the penalties for robocalls to ,000. They are also proposing to extend the time after a crime in which prosecutors must bring their case from one years to three years.Commercial robocalls are illegal, but the Federal Trade Commission, which is tasked with investigating and charging those who have violated the anti-Robocall federal law, has a hard time prosecuting offenders within the current one-year time limit. “If you look at the current enforcement efforts, there's been a 0 million fine and million fine that's covered people who've made 100 million robocalls or a couple hundred million robocalls. That's a drop in the bucket of the nearly 50 billion we're going to have this year,” Quilici. “It's going to take a lot more than just enforcement and some better regulation to solve the problem."Until legislation to crack down on people who make robocalls passes, Quilici suggests:  1674

A federal judge in San Diego on Friday called the Trump administration's plan outlining how the US government intends to reunite migrant children who were separated from their families with parents who have been deported "very impressive."US officials will first work to determine parentage and resolve any safety concerns for the child and then seek to reunite families. The submitted plan said there are 365 separated children with parents outside the US in the care of the Department of Health and Human Services, but officials later corrected that number.Scott Stewart, deputy assistant attorney general, said during a 40-minute joint status call Friday afternoon among the judge, the government, the American Civil Liberties Union and other nongovernmental organizations assisting with reunifications of separated families that the government actually has 386 children in its custody whose parents were deported. Stewart clarified that the reunification plan filed late Thursday night "was not made up to date." 1024