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As we're all focused on the current rollout of the COVID-19 vaccine, a technology known as thin-film freezing is getting a lot of attention. It's groundbreaking and could change the way we administer drugs or use medicine in general.You've probably heard about the need to keep the COVID-19 vaccine cold. It has to be so cold, in fact, that the shipment and transport are challenging. Well, what if that vaccine could be turned into powder?“What we’ve most recently been working on is the elimination of cold chain by storing as a powder, a dry powder where the drug is much more stable than if it was stored as a liquid or as a frozen liquid,” said co-inventor Dr. Robert Williams.Williams said it would eliminate the need for extreme cold storage and transport. The technology isn't new. He got a research grant and came up with it about 15 years ago.Williams, who is also a pharmacy professor at the University of Texas in Austin, said they were working on the technology and its multiple uses when the pandemic hit. And all of a sudden, they got a lot of attention.“We have published over 70 papers on the technology and using it for different products- it’s quite a mature process," Williams said. "We developed it because with other vaccines, the majority of the vaccine cost is in wastage because of this cold chain issue, so we published several key papers where we showed our thin-film freezing technology would protect vaccines - and you wouldn’t need cold chain storage.”Glenn Mattes, President, and CEO of TFF Pharmaceuticals added that the powders can be converted to topical preparations and they are currently working with the US Army to take some of the preparations and would then administer them directly through the eye.TFF is launching thin-film freezing into development through the FDA process. “I use the term ubiquitous because it is and disruptive because it is,” Mattes said. He added that they've explored their technology in the cannabinoid realm. But, as for the COVID vaccine, they're aiming for a second-generation usage.“To truly eradicate the pandemic, you have to have a global response," Mattes said. "The companies we’ve been speaking to certainly recognize the broad utilization of the technology but the application to the developing world, rural area, remote areas, where you can take a powder and inhale it or take the powder and reconstitute it has tremendous potential."Experts say it is only just the beginning as they launch their technology into a new world. 2511
As pressure mounts for congressional action on gun control, it's unclear just how much can be done given the thick political fog that shrouds any major legislative effort on Capitol Hill -- especially in an election year.President Donald Trump tweeted Thursday that Congress "is in a mood to finally do something on this issue," but lawmakers are at home on a weeklong recess and it's too soon to tell if there's enough appetite to tackle gun legislation when they return next week. Republican leadership in the House and Senate have been silent on the question.A number of proposals to curb gun violence are floating around in Congress, some of which were started last year after a spate of other mass shootings. 727
Authorities in Costa Rica say that a body has been found on the Airbnb property where missing Florida woman, 36-year-old Carla Stefaniak, was staying.Costa Rica's Judicial Investigation Agency (OIJ) tells WFTS that the body was buried in a mountainous area located in the back of the property, less than 200 feet away from where Stefaniak had been staying. OIJ agents had been searching the area with specialized dogs. At this time, authorities have not been able to confirm that the body is Stefaniak.In Spanish, Walter Espinoza, the director general of the OIJ said, “the body was in a state of decomposition but the preliminary observation does verify the body is a woman.”In a press conference on Monday, Espinoza said that biological fluids consistent with blood were discovered inside the Airbnb property. The blood has been sent to labs for testing.The body cannot be positively identified by officials until an autopsy is performed.Stefaniak hasn't been seen or heard from since Tuesday, November 27. She traveled to Costa Rica with her sister-in-law, April Burton, on November 22 to celebrate her birthday. Burton flew back on November 27. Stefaniak had plans to return to the United States on November 28, bound for Florida, but never arrived for her flight. She checked into her Airbnb, located at Calle Hoja Blanca in San Antonio de Escazú, for one night on November 27. According to Burton, the last thing they knew about Stefaniak was that she was inside that Airbnb on the night of November 27. The last time Burton spoke to Stefaniak, she told her that it was raining crazy and the power went out. She continued with, "it's pretty sketchy here," according to Burton.The final photograph Stefaniak sent family members was from inside the Airbnb. Family members shared the image with WFTS, seen below.</p><p>"The guards (at the apartment complex that housed the Airbnb) told us that she left at 5 in the morning with all of her bags and got into an Uber. She wouldn’t do that, her flight was at 1:30 p.m. She’s never been early for anything in her life she wouldn’t leave to go to the airport at 5:30 a.m.," Burton said.The Airbnb listing for "Villa Buena Vista" has since been removed from Airbnb's website.WFTS spoke to Airbnb officials, who say they have reached out to Carla's family as well as the FBI, OIJ and the local embassy.Stefaniak's brother flew down to Costa Rica on Friday to search for his sister. Her father flew down to Costa Rica on Monday afternoon.This is a developing news story and will be updated as more information becomes available. 2718
BALTIMORE — Americans stepped up their home purchases in June by a robust 20.7% after the pandemic had caused sales to crater in the prior three months. But the housing market could struggle to rebound further in the face of the resurgent viral outbreak and a shrinking supply of homes for sale. Sales of existing homes rose last month to a seasonally adjusted annual rate of 4.72 million, the National Association of Realtors said. Their data showed all four regions of the country saw growth, with the west experiencing a larger increase. The data included single-family homes, townhomes, condominiums and co-ops. Despite the sharp monthly gain, purchases are still down 11.3% from a year ago, when homes had sold at an annual pace of 5.32 million.Inventory remains an issues, according to the National Association of Realtors (NAR). A low number of available homes was an issue before the pandemic. Total inventory is down 18.2 percent from a year ago, according to the data. The low supply and increasing demand could cause a spike in the price of homes.“Home prices rose during the lockdown and could rise even further due to heavy buyer competition and a significant shortage of supply," said Lawrence Yun, NAR’s chief economist.The median price for exisiting-home sales in June was 3.5 percent higher than a year ago. This is an ongoing trend, NAR says the median price has increased each of the last 100 months. 1428
At least 257 people have been killed in a military plane crash near Algeria's capital, Algiers, state media reports.The aircraft crashed near the Boufarik air base, between Algiers and the city of Bilda. Ten of those killed were the plane crew, according to state-run Radio Algerie.It was not immediately clear whether there were any survivors.TV station Ennahar showed images of smoke rising from the plane's fuselage, tilted to one side, with part of the aircraft sticking out above olive trees. Dozens of bodies were seen in numbered bags as paramedics and firefighters worked at the crash site.The-CNN-Wire 618