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Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

CHARLOTTE, N.C. (AP) — Police say a fourth person has died after being shot earlier this week during an impromptu celebration in North Carolina. The Charlotte-Mecklenburg Police department issued a release saying Dairyon Dejean Stevenson died Tuesday while being treated for a gunshot wound received during the shooting early Monday. 342

CARLSBAD, Calif. (KGTV) -- First responders in Carlsbad are prepared for any emergency, thanks to their state of the art training facility."This is how we become good," says Carlsbad Fire Captain Scott Tucker. "This is our hallowed ground where we get to spend all the time, make the mistakes here, so we don't make them out there."The Carlsbad Safety Training Center spans four acres. It includes a four-story live burn tower, a two-story home, and a main street replica. It also has two shooting ranges, classrooms, and computer simulation rooms.The parking lot can also be used for driving simulations and tests."It's realistic training," says Carlsbad Police Captain Peter Pascual. "The officers can utilize what they learn in the training environment, out in the field."The shooting ranges are adaptable, letting agencies set up different scenarios. They can even drive cars into the range. "It allows us to get in the right frame of mind in how to survive and solve these problems in the field," says Pascual. "We try to create scenarios that are realistic and functional for the success of the officers in the field.""It allows us to get a good foundation in training and build on stuff that we normally don't get to do," says Tucker.Facility Manager Jason Kennedy says the complex tries to stay as modern as possible, always adding more ways to train."We're always looking forward, cause training is so dynamic," says Kennedy. "We're trying to look forward at what things are emerging in the environment."The facility has become so popular, other state and federal agencies have rented the facility from Carlsbad for their own training events.This year, 28 different agencies from around California and the rest of the United States have booked time to train in Carlsbad. Hundreds have stopped by either for tours or training since it opened."It is movie-esque," says Tucker. "It's an amazing facility, and it is state of the art."To learn more about the facility, click here. 1993

CHICAGO (AP) — While on trial for child pornography in 2008, R. Kelly still found time to talk to fans, give autographs and to meet an underage girl he later invited to his home, according to prosecutors who depicted the R&B star as manipulative and sometimes violent.Other accusers included a girl who met Kelly at her 16th birthday party and a hairdresser who expected to braid the singer's hair only to find that he wanted oral sex instead, court documents said.The accounts emerged Saturday as Kelly made his first court appearance since being accused of sexually abusing four people in a case that could produce another #MeToo reckoning for a celebrity.A judge gave Kelly a chance to go free while awaiting trial, setting bond at million. That means the 52-year-old Grammy winner must post 0,000 to be released or remain behind bars until he is tried on the allegations that date back as far as 1998 and span more than a decade.The prosecution released four detailed documents — one for each accuser — outlining the basis for the charges.The 16-year-old girl who attended Kelly's trial got his autograph after a court session. He later invited her to his home in the Chicago suburb of Olympia Fields, where they had sex multiple times, according to the documents, which said he also slapped, choked and spit on her.In 1998, another girl reported meeting Kelly at a restaurant where she was having a 16th birthday party. Kelly's manager gave her the singer's business card and suggested she call Kelly. The girl's mother heard the exchange, took the card and told the manager her daughter was 16.But her daughter later retrieved the card from her purse. She contacted Kelly, who gave her instructions and money that she assumed was for the taxi fare to his studio, where they had sex periodically for a year, the documents said.In early 2003, a Chicago hairdresser told prosecutors that she thought she was going to braid Kelly's hair, but he pulled down his pants and instead tried to force her to give him oral sex. The woman, who was 24, was able to pull away, but Kelly ejaculated on her and spit in her face, the documents said.Prosecutors also described a witness who had access to videotapes showing Kelly having sex with a 14-year-old girl. The witness turned a tape over to authorities and identified the girl, who repeatedly stated her age on the footage, according to the documents.Kelly's DNA was found in semen on one of the accuser's shirts, and semen found on a shirt worn by another was submitted for DNA testing, Cook County State's Attorney Kim Foxx said. It was not clear when the accusers turned the shirts over to authorities, whether it was shortly after the abuse or more recently.At the bond hearing, Kelly's attorney, Steve Greenberg, said his client is not a flight risk. He told the judge, "Contrary to the song, Mr. Kelly doesn't like to fly." One of Kelly's best-known hits is "I Believe I Can Fly."Greenberg said Kelly "really doesn't have any more money," suggesting that others had mismanaged his wealth. Still, he said he expected that Kelly would be able to come up with enough money for bail.The judge called the allegations "disturbing." The singer-songwriter looked down at the floor as the judge spoke.After the hearing, Greenberg told reporters that Kelly did not force anyone to have sex."He's a rock star. He doesn't have to have nonconsensual sex," Greenberg said.The judge ordered Kelly to surrender his passport, ending his hopes of doing a tour of Europe in April. Kelly defiantly scheduled concerts in Germany and the Netherlands despite the cloud of legal issues looming over him. Greenberg denied that any tour was planned.The recording artist, whose legal name is Robert Kelly, has been trailed for decades by allegations that he violated underage girls and women and held some as virtual slaves. He was charged with 10 counts of aggravated sexual abuse.Kelly, who was acquitted of child pornography charges in 2008, has consistently denied any sexual misconduct. He broke into the R&B scene in 1993 with his first solo album, "12 Play," which produced such popular sex-themed songs as "Bump N' Grind" and "Your Body's Callin'."He rose from poverty on Chicago's South Side and has retained a sizable following. Kelly has written numerous hits for himself and other artists, including Celine Dion, Michael Jackson and Lady Gaga. His collaborators have included Jay-Z and Usher.The jury in 2008 acquitted Kelly of child pornography charges that centered on a graphic video that prosecutors said showed him having sex with a girl as young as 13. He and the young woman allegedly seen with him denied they were in the 27-minute video, even though the picture quality was good and witnesses testified it was them, and she did not take the stand. Kelly could have been sentenced to 15 years in prison.Charging Kelly now for actions that occurred in the same time frame as the allegations from the 2008 trial suggests the accusers are cooperating this time and willing to testify.Because the alleged victim 10 years ago denied that she was on the video and did not testify, the state's attorney's office had little recourse except to charge the lesser offense under Illinois law, child pornography, which required a lower standard of evidence.Each count of the new charges carries up to seven years in prison, and the sentences could be served consecutively, making it possible for him to receive up to 70 years. Probation is also an option.The walls began closing in on Kelly after the release of a BBC documentary about him last year and the multipart Lifetime documentary "Surviving R. Kelly," which aired last month. Together they detailed allegations that he held women against their will and ran a "sex cult."#MeToo activists and a social media movement using the hashtag #MuteRKelly calling on streaming services to drop Kelly's music and promoters not to book any more concerts. Protesters demonstrated outside Kelly's Chicago studio. 6010

Can someone in this election truly be undecided in this election? Sure they can. With less than 70 days to go until the election, undecided voters are poised to play a deciding role in whether President Donald Trump or Joe Biden is the president of the United States come the end of January. GEOGRAPHY MATTERSWhile undecided voters matter everywhere, they really matter in crucial counties in swing states. Luzerne County, Pennsylvania, is one example. In 2008 and 2012, this county, which encompasses towns like Wilkes-Barre, voted for President Barack Obama. In 2016, the county voted for Trump. Luzerne is one of three counties in Pennsylvania to have flipped like that. Political scientists refer to counties like these as "pivot counties." WHAT UNDECIDED VOTERS ARE SAYINGRobert Rinaldi is a school bus driver in the county. His lunch buddy, Gene, at D's Diner likes Trump but Rinaldi isn't sure. "I guess I’m hearing a lot of these negative stories and it’s confusing me," Rinaldi said. "Like for instance, this last one with his sister, a retired judge, she’s blasting the guy," Rinaldi said. Meanwhile, Rinaldi is unsure about Joe Biden. He is growing agitated Democrats repeatedly say he is from nearby Scranton. "It's starting to get old, I understand he used to live here but he's been gone for so long," Rinaldi said. Other customers are undecided for other reasons"I don’t think I’ll ever vote unless something drastic happens," Aubree Patronick, a mom said while eating a club sandwich. Patronick doesn't think she'll cast a vote in this year's election. She is tired of the noise and angry Facebook posts."I don’t need a thousand people coming at my comments," Patronick said. Then there is John Colon, who just left the Army. "I truly don’t know who the lesser of two evils is," Colon said, commenting about Biden and Trump. 1850