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Sadly, my lovely client lost his brave fight against Oesophageal cancer last week. A fantastic man with a love of baking that saw him get to the finals of GBBO, write a wonderful book, Bake It Great and do so much more. Always in our thoughts.https://t.co/S61Zgm3Vms— Anne Kibel (@AKAManagement) November 3, 2020 325

SAN DIEGO — The twists and turns of the coronavirus related restrictions took a toll on Cycle OM in Little Italy.“You're open, you’re shut, you’re open, you’re shut,” founder Dana Pare says.This time, Pare decided to forego the opportunity to expand onto the sidewalk, unlike other gyms in San Diego. Instead, she permanently moved all of her classes onlineShe and her teachers deliver them live and on-demand via zoom."We want to adapt, move forward, stay healthy, get stronger, and this to me is the new way," Pare said.The move comes with costs and benefits.Pare reduced her space in Little Ital by half - keeping just enough to maintain a professional setting for her live workouts.She also reduced her staff from 15 to about five."That was a very, very difficult decision," Pare says.But Pare also cut her prices in half - money she'll need to market aggressively online.David Marino, co-founder of commercial real-estate firm Hughes Marino, says he's seeing an increase in companies trying to sublease out their office space - amid an overall drop in demand."Your competitive advantage was location, was that you had a physical space people could walk into and have a relationship with you and I think that's really what's under seige right now.Pare says she's now seeing participants from outside San Diego."We're flexible," she says, "we're yogis." 1364

SAN DIEGO (AP) — Eric Hosmer hit three-run doubles in consecutive innings to ruin Madison Bumgarner's Arizona Diamondbacks debut and give the San Diego Padres a 7-2 victory in Jayce Tingler’s first game as manager. The six RBIs tied Hosmer’s career-high and gave 24-year-old right-hander Chris Paddack the win in his first opening day start. Hosmer’s doubles came off Bumgarner in the sixth inning and Kevin Ginkel in the seventh. Both were with two outs.The 30-year-old Bumgarner allowed only two hits before struggling in the sixth.The Friars continue their four-game season-opening series against the Diamondbacks on Saturday.RELATED COVERAGE: Cardboard Padres fans to fill Petco Park's stands during 2020 seasonLocal company to help fill silence during MLB seasonFan hoping to "share" view overlooking Petco Park during baseball season 847

SAN DIEGO - (KGTV) A San Diego biotech company is doing research that could lead to a vaccine against the coronavirus.Todd Nelson is the CEO of SGI-DNA in Sorrento Valley. His company invented the first automated gene printer. "We use that system actually to print genes. Genes are made of little building blocks that you've heard of, and we use that to rapidly, and in an automated fashion, print genes that researchers can use around the world for vaccine development. "RELATED: Miramar coronavirus evacuees start petition for quarantine oversightThe printer is called the BIO XP 3200. Roughly, 200 are in use around the world. "We're basically taking an entire laboratory of researchers that are doing various things, and we put it in a box," said Nelson.Researchers are using the printer to write the genes of the coronavirus."Even a nasty little thing like the coronavirus has its own genes, and there are certain genes that make that amenable to being a vaccine, and we know what those are so we put the information into the system, and we push a button and about 8 hours later that potential gene comes out ," said Nelson. RELATED: Mislabeled sample led to release of San Diego coronavirus patientNelson is confident the technology will lead to a vaccine. "We're partnering with pharmaceutical firms to develop that in a very, very rapid fashion in the next 7 to 10 days to develop a vaccine," said Nelson. The company used the same technology to help develop a vaccine for the Bird Flu in 2013. Dan Gibson is the company's chief technology officer and the inventor of the technology used in the gene printer.RELATED: First case of coronavirus confirmed in San Diego"That's really the power of synthetic DNA technology. You can keep up with the virus and write and build many vaccines to fight it and ultimately find a universal solution that puts an end to the coronavirus outbreak." 1900

SAN DIEGO (CNS) - A 47-year-old man accused of intentionally driving a pickup truck off Sunset Cliffs and into the ocean with his twin toddler daughters inside pleaded not guilty today to attempted murder, kidnapping and other charges.Robert Brians, who is also charged in the 13-count criminal complaint with child abuse, making criminal threats, child abduction and burglary, is being held without bail and is due back in court July 22 for a readiness conference.He allegedly drove into the water on the morning of June 13 with his 2- year-old daughters inside the truck. The girls were hospitalized in stable condition, according to a GoFundMe page created to raise money for their medical bills.About 4:30 a.m. that day, the toddlers' mother called 911 to report that Brians had taken their children without permission and allegedly contacted her via ``numerous calls and texts ... clearly stating she may not see (them) again,'' according to the GoFundMe.com page.He allegedly threatened to drive the vehicle off the Coronado Bay Bridge, but was later spotted by officers on Hill Street near Cornish Drive and sped off, careening over the side of a cliff and landing upside down in the water, according to police.Moments later, a canine officer also responding to the emergency, 22- year SDPD veteran Jonathan Wiese, arrived in the area. Reaching the scene of the crash and seeing Brians' pickup upside down in the water, Wiese grabbed a long leash he uses for his service dog, wrapped it around his chest, gave the other end to fellow officers and rappelled down the precipice.Wiese then swam out to the foundering truck and rescued the children and Brians. Medics took all three to hospitals for treatment of injuries that were not considered life-threatening. 1775