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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) -- California’s state electric operator issued a flex alert over the weekend as temperatures climb.According to the California Independent System Operator, the flex alert goes into effect Saturday, September 5, and lasts through Monday, September 7.The operator asked customers statewide to conserve energy from 3 p.m. to 9 p.m. At 6:30 p.m., CAISO declared a Stage 2 emergency and warned of possible rotating power outages.The guidance comes as an excessive heat warning was issued for large swaths of San Diego County over the weekend.RELATED STORIESCheck today's weather forecast in your areaSan Diego County opens cool zones amid heat waveAs of Saturday morning, the National Weather Service said temperatures throughout the county could reach as high as 122, with coastal temperatures in some areas reaching 99 degrees.Meanwhile, a red flag warning was issued for San Diego County’s inland valleys and mountains from 10 a.m. Saturday through 6 p.m. Sunday.The agency says winds will top out around 15 to 20 miles per hour with gusts as high as 25 to 35 miles per hour. 1098

SAN DIEGO (KGTV) - County animal shelters are helping San Diegans "fall in love" for free this season.San Diego County Animal Services (SDDAC) will waive adoption fees for cats at their three shelters this weekend, Friday, Sept. 22 through Sunday, Sept. 24, as part of their "Fall in Love" event.RELATED: Adoption fees lowered as San Diego shelter makes more room for hurricane-impacted animalsCats have been spayed or neutered, have their current vaccinations and flea control, are microchipped, and come with a free veterinary exam in the first 10 days, according to SDDAC.The county's three shelters are open from 9:30 a.m. to 5:30 p.m. Tuesday to Sunday; Adoptions close at 4:30 p.m.RELATED: 'Hurricane Harvey' dogs flown to San Diego from Louisiana up for adoptionAnyone can stop in prior to the promotion to check out cats in person or visit animals service's website to see available cats.The county's three shelters are located at: 967

SAN DIEGO (KGTV) - Ballast Point has introduced its way of giving back to the San Diego community after 20 years in business.Ballast Point is releasing "Made in San Diego," a new beer which will benefit the San Diego Regional Economic Development Corporation. The brewery will donate 50 cents for every case of the beer sold to the EDC Foundation Entrepreneurship Fund.Leaders from the city and Ballast Point officially tapped the beer at Wednesday's San Diego Padres game at Petco Park.RELATED: San Diego-based Ballast Point to become Disneyland's first on-site brewery"As a brewery that has called San Diego home for over two decades, we couldn’t be more excited about this announcement," Marty Birkel, president of Ballast Point Brewing Company, said. "This community has embraced us from a small home brew supply shop to a globally distributed brewery, and we want to honor our hometown supporters while empowering other local business owners to pursue their passion – just like Ballast Point did."The beer is expected to generate about ,000 a year for the EDC program for small businesses. The EDC says Ballast Point itself had 7 million of total economic activity in the region last year alone.So what does "Made in San Diego" taste like?RELATED: "Brewchive" preserves?history?of San Diego craft brewing industryBallast Point describes the brew as a golden ale with toasted bread aroma and flavor from Munich malt. There's also a soft bitterness from Cascade and Mosaic hops and the beer's can features many of San Diego's unique cities.Ballast Point will offer the beer on draft in San Diego County later in April and available in six-pack 12 oz. cans around the county at the end of May. 1754

SAN DIEGO (KGTV) — Brendan Watters had big plans for Ballast Point the moment his company took control March 2. That includes creating new beers, and driving a wrapped bus around San Diego for two months announcing that the iconic craft brewery was back under local control. All of that hit a snag two days after sale closed, when Gov. Gavin Newsom announced a State of Emergency because of the coronavirus outbreak. "So basically a week after we were closing up operations," said Watters, the brewery's CEO, who moved to San Diego after the sale. "We had to pivot straight away."Watters' company, Kings and Convicts, bought Ballast Point from Constellation Brands, a Fortune-500 beverage company that paid billion for the San Diego brewer in 2015. Watters declined to disclose the sale price, but did confirm it was less than billion. He said Ballast Point, which launched in San Diego in 1996, lost some of its local charm under an international brand. He says he plans to bring that back, with two new beers launching this summer and an emphasis on design, such as the famous oceanic art that accompanies each one. Still, he faced an unprecedented challenge two days after closing. The tap rooms all shut down, eviscerating 50 percent of its revenue (Watters estimates total revenue fell as much as 60 percent). Watters says the brewery focused on its distribution, and was aided by a federal stimulus loan. Now, the Miramar and Little Italy tasting rooms are reopening with social distancing alterations, such as spaced out tables, and smartphone ordering systems. Watters says he was able to recall most of the brewery's 550 employees. He says Ballast Point can last with the reduced capacity in the short-term, but the longer this goes, the harder it will be. 1780

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