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A genetic analysis of COVID-19 patients suggests that blood type might influence whether someone develops severe disease.Scientists who compared the genes of thousands of patients in Europe found that those who had Type A blood were more likely to have severe disease while those with Type O were less likely.Wednesday’s report in the New England Journal of Medicine does not prove a blood type connection, but it does confirm a previous report from China of such a link.“Most of us discounted it because it was a very crude study,” Dr. Parameswar Hari, a blood specialist at the Medical College of Wisconsin, said of the report from China. With the new work, “now I believe it,” he said. “It could be very important.”Other scientists urged caution.The evidence of a role for blood type is “tentative ... it isn’t enough of a signal to be sure,” said Dr. Eric Topol, head of the Scripps Research Translational Institute in San Diego.The study, involving scientists in Italy, Spain, Denmark, Germany and other countries, compared about 2,000 patients with severe COVID-19 to several thousand other people who were healthy or who had only mild or no symptoms. Researchers tied variations in six genes to the likelihood of severe disease, including some that could have a role in how vulnerable people are to the virus. They also tied blood groups to possible risk.Most genetic studies like this are much larger, so it would be important to see if other scientists can look at other groups of patients to see if they find the same links, Topol said.Many researchers have been hunting for clues as to why some people infected with the coronavirus get very ill and others, less so. Being older or male seems to increase risk, and scientists have been looking at genes as another possible “host factor” that influences disease severity.There are four main blood types — A, B, AB and O — and “it’s determined by proteins on the surface of your red blood cells,” said Dr. Mary Horowitz, scientific chief at the Center for International Blood and Marrow Transplant Research.People with Type O are better able to recognize certain proteins as foreign, and that may extend to proteins on virus surfaces, Hari explained.During the SARS outbreak, which was caused by a genetic cousin of the coronavirus causing the current pandemic, “it was noted that people with O blood type were less likely to get severe disease,” he said.Blood type also has been tied to susceptibility to some other infectious diseases, including cholera, recurrent urinary tract infections from E. coli, and a bug called H. pylori that can cause ulcers and stomach cancer, said Dr. David Valle, director of the Institute of Genetic Medicine at Johns Hopkins University.Bottom line: “It’s a provocative study. It’s in my view well worth publishing and getting out there,” but it needs verification in more patients, Valle said.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3086

A chaotic scene unfolded as a massive caravan of Honduran migrants reached the Guatemala-Mexico border Friday.What appeared to be tear gas was fired as the crowd pushed towards Mexican police at the border, CNN's Bill Weir reported from the scene."There are children in this crowd. ... This is utter chaos at the moment. You've got people with Honduran flags climbing the fences. Now we're being pushed back," Weir said.Mexican officials had said people seeking asylum would be processed at the border. But it's unclear what will happen next.Members of the group -- many with children in tow -- had cheered and chanted as they streamed toward the port of entry, with celebratory airhorns blaring.The migrant caravan is now stopped on a bridge linking the two countries as a police barricade set up by Mexico is blocking them from entering. 852

A Howard County, Maryland fire fighter and first responder wasn’t even working when he risked his own life to save another.  Ryan Glenn said it was just instinct.  Glenn said he was driving along The Chesapeake Bay Bridge when he saw a man threatening to jump.  “I saw the gentleman standing on the railing and he was on the railing holding on to the guardrail,” said Glenn.At it’s center, The Chesapeake Bay Bridge is 180 feet, a dizzying height for anyone. Glenn was off duty, happened to be on the bridge and jumped in to help.“I said hey, there’s a lot of people who care about you.  Let’s not do this, come down and talk.  I’m here for you, I care about you,” Glenn told the distraught man.With the help of two other off duty officers, who just happened to be on the bridge as well, Glenn began the negotiating.“I managed to get closer and closer to him and probably about two feet away from him, I said, just take my hand and let’s get you down from here.”But that’s not what happened. “He looks down at the water and looked at me again and then he did the unthinkable.  He went from the railing of the bridge to a cross member I-beam type of material on the bridge and jumped on it.  At that point, he was just holding on by his grip and his feet were dangling over the water” remembered Glenn.As a trained professional, Glenn was comfortable risking his own life to save another.“At that point, all three of us, it was just like instinct, all three of us, reached over the railing and grabbed him and pulled him over,” Glenn said.“You’re conditioned to it, if you see something wrong, we run to the problem, we try to fix things.”The man was taken to safety and then to the hospital for treatment. 1758

A football coach. An athletic director. And young, fresh-faced students.They are among the 17 people killed by a gunman at Marjory Stoneman Douglas High School in Parkland, Florida, on Wednesday.Broward County Sheriff Scott Israel said Thursday that all families who lost loved ones in the shooting have been notified.  332

A former Israeli government official says extraterrestrials have been in contact with Earth, and that President Donald Trump is aware of an agreement between the U.S. and the aliens.The official, Haim Eshed, is the former head of Israel’s Defense Ministry’s space directorate and made his comments during an interview with the Yediot Aharonot newspaper. Eshed is a respected professor and retired general, according to NBC News.Parts of the interview, originally given in Hebrew, were translated over the weekend and published in the Jerusalem Post."The Unidentified Flying Objects have asked not to publish that they are here, humanity is not ready yet," claims Eshed.Eshed described a kind of galactic federation that had signed agreements of cooperation. He claims there is an agreement between the U.S. government and the aliens to conduct experiments.He added that Trump is aware of the extraterrestrials’ existence and was asked not to reveal any information in order to prevent “mass hysteria.”Officials from the White House and Israeli government did not respond to media requests for comment. A spokesman for NASA told NBC News that one of the agency’s key goals was to search for signs of life in the universe, but that they had yet to find any.Eshed’s ideas were shared in more details in a book published in November called “The Universe Beyond the Horizon - conversations with Professor Haim Eshed.” 1420

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